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Early-Life Nutrition and Chronic Respiratory Diseases

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Pediatric Nutrition".

Deadline for manuscript submissions: closed (15 September 2020) | Viewed by 2477

Special Issue Editor


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Guest Editor
Erasmus MC- Sophia Children’s Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands
Interests: asthma; atopic diseases; diet; environment; (epi)genetics; epidemiology; microbiome

Special Issue Information

Dear Colleagues,

Chronic respiratory diseases during the life course are a major public health concern. Prevalence varies from 5% to 10% for asthma in childhood, up to 30% for asthma-related symptoms such as wheezing in younger children, and up to 22% for chronic obstructive pulmonary disease (COPD) among adults. Chronic respiratory diseases across the life course are related to a reduced quality of life and are leading causes of hospitalization and health care costs. The morbidity of these diseases remains high, due to the largely unknown etiology of chronic respiratory diseases and to the unknown potential for prevention strategies. Recent studies strongly suggest that the earliest phase of life is an important period for programming of respiratory diseases across the life course. Cohort studies and randomized clinical trials suggest that nutritional factors involving single nutrients, vitamins and supplement intake during pregnancy or infancy play a role in the development of chronic respiratory diseases. Nutrients are generally not consumed in isolation and might interact with each other. Therefore, the focus of research in this field has partly shifted into examining the combined effects of multiple nutrients, food groups, or dietary patterns with specific interest in the diet inflammatory potential and diet quality aspects. The attributable risks of early-life nutrition on the development of chronic respiratory diseases next to common sociodemographic and growth factors, such as body mass index, are of major interest. Finally, the interplay between genetics, epigenetics, and the microbiome with dietary exposures on the development of chronic respiratory diseases is an important and exciting research field.

The objective of this proposed Special Issue on “Early-life Nutrition and Chronic Respiratory Diseases” is to publish selected papers detailing several aspects of early-life nutrition and chronic respiratory diseases, including the timing in life of dietary exposure, the long-term effects of early-life supplement exposure, and the interplay of nutrients with sociodemographic and growth factors, genetics, epigenetics, and the microbiome. Further, early-life nutrition and development of respiratory-related diseases such as atopic dermatitis and allergies will be highlighted.

Assoc. Prof. Liesbeth Duijts
Guest Editor

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Keywords

  • Asthma
  • Atopic diseases
  • Genetics
  • Growth
  • Epigenetics
  • Microbiome
  • Nutrition

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Published Papers (1 paper)

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Research

11 pages, 275 KiB  
Article
Associations of Plasma Fatty Acid Patterns during Pregnancy with Respiratory and Allergy Outcomes at School Age
by Sara M. Mensink-Bout, Trudy Voortman, Marsela Dervishaj, Irwin K. M. Reiss, Johan C. De Jongste, Vincent W. V. Jaddoe and Liesbeth Duijts
Nutrients 2020, 12(10), 3057; https://doi.org/10.3390/nu12103057 - 7 Oct 2020
Cited by 4 | Viewed by 2213
Abstract
Fatty acids might play a role in asthma and allergy development as they can modulate immune responses. We examined among 4260 mother-child pairs participating in a population-based cohort the associations of maternal plasma fatty acid patterns during pregnancy with a child’s respiratory and [...] Read more.
Fatty acids might play a role in asthma and allergy development as they can modulate immune responses. We examined among 4260 mother-child pairs participating in a population-based cohort the associations of maternal plasma fatty acid patterns during pregnancy with a child’s respiratory and allergy outcomes at school-age. In mid-pregnancy, 22 individual fatty acids were measured from maternal blood. Three patterns were previously identified by principal component analysis: A ‘high n-6 polyunsaturated fatty acid (PUFA)’, a ‘monounsaturated and saturated fatty acid’, and a ‘high n-3 PUFA’ pattern. At the age of 10 years, a child’s lung function was assessed by spirometry, current asthma and physician-diagnosed inhalant allergy by questionnaire, and inhalant allergic sensitization by skin prick tests. A higher ‘high n-6 PUFA’ pattern was associated with a higher forced expiratory volume in 1 s/forced vital capacity and forced expiratory flow after exhaling 75% of forced vital capacity (Z-score difference (95% CI) 0.04 (0, 0.07) and 0.04 (0.01, 0.07), respectively, per SD increase in the fatty acid pattern). We observed no associations of maternal fatty acid patterns with a child’s asthma or allergy outcomes. Our results showed limited associations of maternal patterns of high n-6 PUFA concentrations in pregnancy with a better lung function in school-aged children. Full article
(This article belongs to the Special Issue Early-Life Nutrition and Chronic Respiratory Diseases)
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