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Nutrients
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Obesity and Related Diseases: The Role of Nutrition
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Obesity and Related Diseases: The Role of Nutrition

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Obesity".

Deadline for manuscript submissions: closed (15 March 2025) | Viewed by 2382

Special Issue Editor

Dr. Jody Dushay

E-Mail Website
Guest Editor
Division of Endocrinology and Metabolism, Beth Israel Deaconess Medical, Boston, MA, USA
Interests: nutrient metabolism; lipid disorders; metabolic disease; obesity; type 2 diabetes; weight loss; nutrition; macronutrient metabolism; metabolic associated steatotic liver disease; insulin resistance; lifestyle modification

Special Issue Information

Dear Colleagues,

We are pleased to announce a Special Issue of Nutrients that will focus on the role of nutrition in the management of obesity and related diseases. This Special Issue will include articles on the latest advancements and practical applications in dietary strategies that promote effective weight loss and weight loss maintenance to mitigate obesity-related health risks. We welcome submissions from researchers, clinicians, and nutritionists addressing topics such as personalized diets, novel dietary interventions, behavioral approaches, and the impact of specific nutrients on obesity and metabolic health. Articles may present evidence-based insights, clinical outcomes, and potential implications for public health policy. Literature reviews are also welcome. Our goal is to provide a comprehensive resource for healthcare professionals and individuals navigating the complex landscape of obesity management through informed nutrition strategies. Submissions should contribute to fostering a deeper understanding of dietary interventions that support sustainable weight loss and improve overall health outcomes. I hope you will consider submitting a manuscript that will help advance knowledge and empower healthier lifestyles through cutting-edge research in nutrition and obesity management.

Dr. Jody Dushay
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutrient metabolism
  • lipid disorders
  • metabolic disease
  • obesity
  • type 2 diabetes
  • weight loss
  • nutrition
  • macronutrient metabolism
  • metabolism-associated steatotic liver disease
  • insulin resistance
  • lifestyle modification

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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14 pages, 2032 KiB  
Article
Vaccinium oldhamii Fruit Inhibits Lipid Accumulation in 3T3-L1 Cells and Diet-Induced Obese Animals
by Young-Hyeon Lee, Mikyoung You and Hyeon-A Kim
Nutrients 2025, 17(8), 1346; https://doi.org/10.3390/nu17081346 - 14 Apr 2025
Viewed by 287
Abstract
Background/Objectives: Obesity is a significant global health concern, and the natural bioactive compounds with anti-obesity effects remain challenging. This study aims to examine the anti-obesity effect and the potential mechanism of Vaccinium oldhamii fruit water extract (VOW). Methods: Lipid accumulation, AMP-activated protein kinase [...] Read more.
Background/Objectives: Obesity is a significant global health concern, and the natural bioactive compounds with anti-obesity effects remain challenging. This study aims to examine the anti-obesity effect and the potential mechanism of Vaccinium oldhamii fruit water extract (VOW). Methods: Lipid accumulation, AMP-activated protein kinase (AMPK) activity, and Wnt/β-catenin signaling were evaluated in 3T3-L1 cells. In high-fat and high-sucrose diet (HFHSD)-induced obese mice, body weight, food intake, fat weight, serum lipid profiles, and adipogenic transcription factors were assessed. The most effective VOW fraction was selected by Oil Red O (ORO) staining and its mechanism was studied in 3T3-L1 cells. Results: VOW treatment significantly inhibited cellular lipid accumulation and suppressed phosphorylation of AMPK and its downstream protein, acetyl-CoA carboxylase (ACC). VOW also decreased adipogenic-associated protein expressions such as the peroxisome proliferator-activated receptor-γ (PPAR-γ), CCAAT/enhancer-binding proteins α (C/EBP α), sterol regulatory element binding protein-1c (SREBP-1c), and fatty acid synthase (FAS). The enhanced effect of VOW was abolished by the knockdown of AMPK with siRNA. The inhibitory effect of VOW on differentiation depended on the treatment period, even though VOW treatment downregulated the C/EBP β expression at the early phase of differentiation. VOW dramatically reduced activation of AMPK, thereby downregulating adipogenic-associated proteins. Furthermore, the butanol fraction (BtOH) of VOW showed the most powerful effect of VOW dose-dependently reduced lipid accumulation by suppressing the phosphorylation of AMPK. Consistent with inhibited lipid accumulation in vitro, VOW reduced body weight and white adipose tissue weight in the HFHSD-induced obese animal model. Conclusions: Overall, our study suggested that the anti-adipogenesis effect of VOW and its BtOH fraction involved the activation of AMPK. Full article
(This article belongs to the Special Issue Obesity and Related Diseases: The Role of Nutrition)
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16 pages, 3457 KiB  
Article
Body Mass Index and Weight Change as Predictors of Hypertension Development: A Sex-Specific Analysis
by Koki Kosami, Masanari Kuwabara, Akira Okayama and Ryusuke Ae
Nutrients 2025, 17(1), 119; https://doi.org/10.3390/nu17010119 - 30 Dec 2024
Cited by 1 | Viewed by 1176
Abstract
Background/Objectives: Obesity is associated with food intake, drinking, and nutrition. It is necessary to examine the association between body mass index (BMI), body weight changes, and the incidence of hypertension, focusing on potential sex differences. Methods: A retrospective two-point [...] Read more.
Background/Objectives: Obesity is associated with food intake, drinking, and nutrition. It is necessary to examine the association between body mass index (BMI), body weight changes, and the incidence of hypertension, focusing on potential sex differences. Methods: A retrospective two-point cohort study was conducted using data from the Japanese Specific Health Checkup program from 2011 to 2013. Multivariable logistic regression analyses were employed to assess associations between BMI, weight change, and hypertension onset, adjusting for age, sex, and lifestyle factors, including smoking, drinking, and exercise. Results: In total, 397,181 participants were analyzed. A higher BMI was linked to a higher risk of hypertension, with an odds ratio (OR) of 1.11 (95% confidence interval [CI]: 1.11–1.12) for both sexes. Women aged 40–65 showed higher ORs than men. Weight gain was associated with developing hypertension, with an OR (95% CI) of 1.09 (1.09–1.10) in men and 1.08 (1.07–1.08) in women. This association held across all BMI levels, even among individuals without obesity, with the effect being generally stronger in men. Conclusions: Both BMI and weight change contribute to the development of hypertension among the Japanese healthy population, with differences based on sex. Weight reduction may reduce the risk of hypertension for individuals with and without obesity, emphasizing the importance of weight stability through food and nutrition control, particularly for women. Full article
(This article belongs to the Special Issue Obesity and Related Diseases: The Role of Nutrition)
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Other

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21 pages, 2857 KiB  
Systematic Review
Child and Adolescent Health Programs in Obesity and Depression: A Systematic Review and Meta-Analysis
by Ana Sarmiento-Riveros, María José Aguilar-Cordero, Juan A. Barahona-Barahona, Gabriel E. Galindo, Claudia Carvallo, Fernando A. Crespo and Héctor Burgos
Nutrients 2025, 17(6), 1088; https://doi.org/10.3390/nu17061088 - 20 Mar 2025
Viewed by 489
Abstract
Obesity and depression are public health issues of increasing concern worldwide. This study aims to evaluate programs that address obesity and their impact on depressive symptoms in children and adolescents. Obesity and depression share a bidirectional relationship, where each can serve as both [...] Read more.
Obesity and depression are public health issues of increasing concern worldwide. This study aims to evaluate programs that address obesity and their impact on depressive symptoms in children and adolescents. Obesity and depression share a bidirectional relationship, where each can serve as both a cause and a consequence of the other. Methods: A systematic review and meta-analysis were conducted following PRISMA criteria, with the registration recorded under PROSPERO code (CRD42024550644). The selected publications report on intervention programs for obesity and depression in children and adolescents aged 6 to 18 years. The selection was from databases including PUBMED, SCOPUS, LILACS, COCHRANE, WOS, SciELO, and ScienceDirect, using PICOS criteria to define inclusion. ROB-2 and ROBINS-1 were applied to assess bias. Results: Out of 3376 articles reviewed, eight met the inclusion criteria, some including several programs. These programs varied in duration and type, demonstrating changes in reducing Body Mass Index (BMI) and depressive symptoms. However, evidence supporting the effectiveness of programs that address both conditions is limited, particularly in developing countries. Additionally, the results exhibit high heterogeneity due to the diversity of evaluation criteria and methodological approaches, highlighting considerable risks of bias. Conclusions: Intervention programs for obesity management show statistically significant effects on depressive symptoms, although there is heterogeneity in the designs for their standardization and long-term follow-up strategies; however, the evaluations consider DSM-5 and ICD-11 criteria, which contributes to homogeneity. It is vital to address these closely related issues from a multidimensional perspective, considering socio-emotional and psychological factors, and to promote early intervention to maximize effectiveness and enhance quality of life at various stages of development. Full article
(This article belongs to the Special Issue Obesity and Related Diseases: The Role of Nutrition)
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