Nutritional Strategies Modulating Neuroinflammation and Oxidative Stress in Neurodegenerative Diseases

Dear Colleagues,

Neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and Huntington’s disease, are characterized by progressive neuronal loss often associated with chronic neuroinflammation and oxidative stress. Emerging evidence indicates that dietary factors and specific nutritional interventions can modulate these pathological processes, offering potential strategies to prevent or slow disease progression. This Special Issue aims to explore the complex interactions among nutrition, neuroinflammatory pathways, and oxidative stress mechanisms in the context of neurodegeneration. We welcome original research, reviews, and meta-analyses that investigate the role of macro- and micronutrients, bioactive compounds, dietary patterns, and nutraceuticals in regulating neuroinflammatory responses and oxidative damage. Studies addressing molecular mechanisms, preclinical models, clinical trials, and translational approaches are particularly encouraged. By providing an integrative platform for multidisciplinary research, this Special Issue seeks to highlight innovative nutritional strategies that may contribute to neuroprotection and improve outcomes in neurodegenerative disorders. Ultimately, understanding how targeted dietary interventions influence neuroinflammation and oxidative stress could pave the way for novel preventive and therapeutic approaches in these debilitating diseases.

Dr. Rossella Rotondo
Dr. Sabrina Donati Zeppa
Guest Editors

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