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The Role of Nutrition in Muscle and Physical Function

A Special Issue of Nutrients (ISSN 2072-6643) belonging to the section "Proteins and Amino Acids".

Deadline for manuscript submissions: 20 February 2027 | Viewed by 630

Editor


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Guest Editor
Department of Nutrition, Aomori University of Health and Welfare, Aomori 030-8505, Japan
Interests: Nrf2 activation; antioxidant activity; foods; biological activity

Special Issue Information

Dear Colleagues,

Skeletal muscle plays a central role in mobility, metabolic regulation, physical performance, and overall health across the lifespan.

Increasing evidence suggests that nutrition profoundly influences muscle mass, strength, mitochondrial function, recovery, and physical function in both healthy individuals and various clinical populations.

Nutritional approaches, including dietary patterns, protein and amino acid supplementation, micronutrients, and bioactive compounds, are attracting growing attention as potential strategies for preserving musculoskeletal health and preventing functional decline.

Topics of interest include, but are not limited to, the following:

  • Nutritional regulation of skeletal muscle metabolism and adaptation;
  • The role of proteins, amino acids, vitamins, minerals, and bioactive compounds in muscle health;
  • Nutrition and mitochondrial function in skeletal muscle;
  • Interactions between nutrition and exercise in muscle function and recovery;
  • Nutritional strategies for sarcopenia, frailty, and other conditions affecting muscle function;
  • Clinical and epidemiological studies on nutrition and physical function;
  • Muscle and physical function in chronic diseases and metabolic disorders;
  • Molecular and cellular mechanisms underlying nutrient-mediated muscle function.

Through this Special Issue, we hope to provide an interdisciplinary platform that advances our understanding of the role of nutrition in maintaining and improving muscle and physical function across diverse populations. Through this Special Issue, we hope to provide an interdisciplinary platform that advances our understanding of the role of nutrition in maintaining and improving muscle and physical function across diverse populations.

Dr. Toshio Norikura
Guest Editor

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Keywords

  • molecular nutrition
  • metabolomics
  • nutrient signaling
  • nutrition and exercise interaction
  • dietary patterns
  • sarcopenia
  • healthy aging
  • amino acids
  • bioactive compounds
  • clinical and epidemiological nutrition

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Published Papers (1 paper)

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Research

21 pages, 1694 KB  
Article
Effects of Highly Branched Cyclic Dextrin-Based Carbohydrate and Protein Co-Ingestion on Endurance Capacity and Metabolic Response in Soccer Players: A Randomized Crossover Trial
by Ki-Tae Song, Hyuck Lee, Jun-Young Sung, Jin-Kuk Baek, Seong-Won Park, Kyu-Jin Hyun, Eun-hui Jin, Ki-Woong Noh and Sok Park
Nutrients 2026, 18(17), 2855; https://doi.org/10.3390/nu18172855 - 1 Sep 2026
Viewed by 480
Abstract
Background/Objectives: Highly branched cyclic dextrin (HBCD) may improve carbohydrate (CHO) availability during soccer-specific intermittent exercise via favorable gastrointestinal properties. Whether co-ingestion with whey protein confers additional ergogenic benefits beyond HBCD alone remains unclear. Methods: Nine male soccer players completed a single-blind, randomized crossover [...] Read more.
Background/Objectives: Highly branched cyclic dextrin (HBCD) may improve carbohydrate (CHO) availability during soccer-specific intermittent exercise via favorable gastrointestinal properties. Whether co-ingestion with whey protein confers additional ergogenic benefits beyond HBCD alone remains unclear. Methods: Nine male soccer players completed a single-blind, randomized crossover trial (≥7-day washout) with three conditions, Placebo (water), CHO, and isocaloric HBCD plus whey protein isolate (CHOP), during a standardized, ~120-min laboratory-based soccer-specific intermittent exercise protocol (not an actual match). The 500-mL beverage, split into two 250-mL servings, was consumed before exercise and at half-time during the exercise protocol. Respiratory quotient (RQ), substrate oxidation, heart rate, RPE, digestive symptoms, running time, and distance were assessed, with condition effects tested via repeated-measures ANOVA at each cycle. Results: Compared with Placebo, CHO increased RQ (p = 0.042) and carbohydrate oxidation (p = 0.048) while reducing fat oxidation (p = 0.034) at the final cycle, reflecting greater late-exercise CHO utilization without improving endurance performance. Compared with Placebo, CHOP significantly improved both running time (p = 0.019) and running distance (p = 0.025), with no significant difference from CHO on either outcome. RPE was significantly lower in CHOP than in Placebo during the latter stage of exercise (p = 0.016). Conclusions: HBCD ingestion before exercise and at half-time promoted greater late-exercise CHO utilization without increasing cardiovascular or gastrointestinal strain. Co-ingestion of whey protein with HBCD provided ergogenic benefits over Placebo by improving fatigue-limited endurance performance, supporting isocaloric CHOP co-ingestion as a practical nutritional strategy for prolonged soccer-specific intermittent exercise. Full article
(This article belongs to the Special Issue The Role of Nutrition in Muscle and Physical Function)
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