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Polyphenol-Rich Foods on Human Health and Diseases

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (15 September 2024) | Viewed by 7836

Special Issue Editor


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Guest Editor
Department of Nutrition, Graduate School of Human Life and Ecology, Osaka Metropolitan University, Osaka 558-8585, Japan
Interests: lifestyle-related diseases; functional food components; reactive oxygen species; bioactive nutrients; anti-oxidant activity
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Special Issue Information

Dear Colleagues,

Unlocking the potential: Polyphenols, abundant in various plant-based foods like vegetables and fruits, possess remarkable antioxidant and anti-inflammatory properties. Beyond this, they exhibit a spectrum of physiological effects known to combat lifestyle-related diseases. Yet, there is a veil shrouding the full scope of polyphenols' physiological impacts. Exploring the intricate workings and mechanisms underlying polyphenols' effects further will be a gateway to advancing health and wellness.

This Special Issue aims to delve deeper into the dynamic interplay between polyphenol-rich diets and human health, inviting studies utilizing in vitro and/or in vivo models alongside human clinical trials to shed light on this vital connection.

Dr. Akiko Kojima-Yuasa
Guest Editor

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Keywords

  • antioxidants
  • reactive oxygen species
  • Nrf2
  • lifestyle-related diseases
  • obesity
  • cancer
  • neurodegenerative diseases
  • inflammatory diseases
  • cardiovascular diseases

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Published Papers (2 papers)

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Research

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22 pages, 6977 KiB  
Article
Ecklonia cava Polyphenols Have a Preventive Effect on Parkinson’s Disease through the Activation of the Nrf2-ARE Pathway
by Yuri Yasuda, Tamaki Tokumatsu, Chiharu Ueda, Manami Sakai, Yutaro Sasaki, Toshio Norikura, Isao Matsui-Yuasa and Akiko Kojima-Yuasa
Nutrients 2024, 16(13), 2076; https://doi.org/10.3390/nu16132076 - 28 Jun 2024
Cited by 1 | Viewed by 6858
Abstract
Parkinson’s disease (PD) is a degenerative neurological disorder defined by the deterioration and loss of dopamine-producing neurons in the substantia nigra, leading to a range of motor impairments and non-motor symptoms. The underlying mechanism of this neurodegeneration remains unclear. This research examined the [...] Read more.
Parkinson’s disease (PD) is a degenerative neurological disorder defined by the deterioration and loss of dopamine-producing neurons in the substantia nigra, leading to a range of motor impairments and non-motor symptoms. The underlying mechanism of this neurodegeneration remains unclear. This research examined the neuroprotective properties of Ecklonia cava polyphenols (ECPs) in mitigating neuronal damage induced by rotenone via the activation of the nuclear factor erythroid 2-related factor 2 (Nrf2)–antioxidant response element (ARE) pathway. Using human neuroblastoma SH-SY5Y cells and PD model mice, we found that ECP, rich in the antioxidant polyphenol phlorotannin, boosted the gene expression and functionality of the antioxidant enzyme NAD(P)H quinone oxidoreductase-1. ECP also promoted Nrf2 nuclear translocation and increased p62 expression, suggesting that p62 helps sustain Nrf2 activation via a positive feedback loop. The neuroprotective effect of ECP was significantly reduced by Compound C (CC), an AMP-activated protein kinase (AMPK) inhibitor, which also suppressed Nrf2 nuclear translocation. In PD model mice, ECPs improved motor functions impaired by rotenone, as assessed by the pole test and wire-hanging test, and restored intestinal motor function and colon tissue morphology. Additionally, ECPs increased tyrosine hydroxylase expression in the substantia nigra, indicating a protective effect on dopaminergic neurons. These findings suggest that ECP has a preventative effect on PD. Full article
(This article belongs to the Special Issue Polyphenol-Rich Foods on Human Health and Diseases)
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Review

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18 pages, 782 KiB  
Review
The Extraction, Biosynthesis, Health-Promoting and Therapeutic Properties of Natural Flavanone Eriodictyol
by Haiaolong Yin, Yaxian Li, Yi Feng, Lei Tian and Ye Li
Nutrients 2024, 16(23), 4237; https://doi.org/10.3390/nu16234237 - 8 Dec 2024
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Abstract
Eriodictyol is a flavanone compound commonly found in several edible plants. Ultrasound-assisted extraction and high-performance liquid chromatography (HPLC) are commonly used methods for the separation and analysis of eriodictyol. Many studies show that some micro-organisms can produce eriodictyol as a host. What is [...] Read more.
Eriodictyol is a flavanone compound commonly found in several edible plants. Ultrasound-assisted extraction and high-performance liquid chromatography (HPLC) are commonly used methods for the separation and analysis of eriodictyol. Many studies show that some micro-organisms can produce eriodictyol as a host. What is more, eriodictyol has a wide range of health benefits, including skincare, neuroprotective, hypoglycemic, anti-inflammatory, and antioxidant activities. In addition, the therapeutic properties of eriodictyol are cardioprotective, hepatoprotective, anticancer, with protective effects on the lungs and kidneys, and so on. This review examines the extraction, biosynthesis, and health and therapeutic properties of the natural compound eriodictyol and its value in medicine and food. Full article
(This article belongs to the Special Issue Polyphenol-Rich Foods on Human Health and Diseases)
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