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Harnessing Nature’s Power: Antioxidants and Anti-Inflammatory Natural Compounds in Health...
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Harnessing Nature’s Power: Antioxidants and Anti-Inflammatory Natural Compounds in Health and Disease

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: 5 August 2026 | Viewed by 1178

Special Issue Editors

Dr. Hua Liu

E-Mail Website
Guest Editor
Stanley Division of Developmental Neurovirology, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Interests: phytochemicals; chemoprevention; microbiome; biomarkers; psychiatric disorders; oxidative stress; inflammation; autism; microRNAs
Dr. Anita A. Panjwani

E-Mail Website
Guest Editor
1. Department of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA
2. Center on Aging and the Life Course, Purdue University, West Lafayette, IN 47907, USA
Interests: phytochemicals; neuropsychiatric disorders; autism spectrum disorder; metabolic disorders; biomarkers; anti-inflammatory diet

Special Issue Information

Dear Colleagues,

With the global rise in health conditions associated with oxidative stress and chronic inflammation, there is a growing need for effective, safe, and sustainable therapeutic approaches. Phytochemicals that exhibit antioxidant and anti-inflammatory properties have emerged as promising candidates for the prevention and treatment of a wide range of diseases, from metabolic disorders to neurodegenerative conditions and beyond. This Special Issue, "Harnessing Nature’s Power: Antioxidants and Anti-Inflammatory Natural Compounds in Health and Disease", seeks to highlight the latest advances in the identification, mechanistic understanding, and application of these bioactive compounds. We welcome original research and comprehensive reviews addressing novel phytochemical sources and their molecular mechanisms of action, including their impacts on cellular signaling pathways, immune modulation, and the gut microbiota, as well as the preclinical and clinical evaluations of these phytochemicals. Submissions on interdisciplinary research concerned with the interface of nutrition, medicine, and biotechnology are also highly encouraged. This Special Issue aims to advance both scientific understanding and practical applications of nature-derived compounds in combating diseases linked to oxidative stress and chronic inflammation.

Dr. Hua Liu
Dr. Anita A. Panjwani
Cuest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oxidative stress
  • inflammation
  • phytochemicals
  • nutrition
  • metabolic disease
  • cancer
  • neurodegerative disorders
  • neurodevelopmental disorders
  • psychiatric disorders
  • molecular mechanisms
  • immune modulation
  • gut microbiota

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Published Papers (2 papers)

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Research

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20 pages, 1683 KB  
Article
Effects of Rosmarinic Acid and Sinapic Acid on the Skeletal System in Ovariectomized Rats
by Maria Zych, Radosław Wolan, Agnieszka Włodarczyk, Piotr Londzin, Weronika Borymska, Ilona Kaczmarczyk-Żebrowska and Joanna Folwarczna
Nutrients 2026, 18(2), 301; https://doi.org/10.3390/nu18020301 - 18 Jan 2026
Viewed by 682
Abstract
Background/Objectives: It is believed that some polyphenols, including phenolic acids, may counteract estrogen deficiency-induced bone loss, decreasing oxidative stress. Moreover, some phenolic acids—among others, rosmarinic acid and sinapic acid—have been reported to increase the serum estradiol concentration in rats. The study aimed [...] Read more.
Background/Objectives: It is believed that some polyphenols, including phenolic acids, may counteract estrogen deficiency-induced bone loss, decreasing oxidative stress. Moreover, some phenolic acids—among others, rosmarinic acid and sinapic acid—have been reported to increase the serum estradiol concentration in rats. The study aimed to investigate the impact of rosmarinic acid and sinapic acid on the skeletal system of rats with estrogen deficiency induced by bilateral ovariectomy. Methods: The study was carried out on mature female rats, divided into sham-operated control rats, ovariectomized (OVX) control rats, and OVX rats treated with estradiol (0.2 mg/kg; positive control), rosmarinic acid (10 and 50 mg/kg), or sinapic acid (5 and 25 mg/kg). The compounds were administered orally for 4 weeks. Serum bone turnover markers, bone mass, mineral and calcium content, macrometric and histomorphometric parameters, as well as mechanical properties were examined. Results: Estrogen deficiency induced osteoporotic changes in ovariectomized control rats, which were slightly counteracted by the administration of estradiol. The phenolic acids slightly counteracted some changes caused by estrogen deficiency, but their administration at higher doses led to further worsening of cancellous bone quality. Conclusions: The results demonstrated that administration of high doses of rosmarinic acid or sinapic acid slightly unfavorably affected the rats’ skeletal system under conditions of estrogen deficiency. Full article
(This article belongs to the Special Issue Harnessing Nature’s Power: Antioxidants and Anti-Inflammatory Natural Compounds in Health and Disease)
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Review

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36 pages, 902 KB  
Review
Sulforaphane in Cutaneous Disorders and Skin Injury: Mechanisms, Evidence, and Clinical Perspectives
by Hua Liu, Claire Y. Shi and Jed W. Fahey
Nutrients 2026, 18(9), 1444; https://doi.org/10.3390/nu18091444 - 30 Apr 2026
Viewed by 16
Abstract
Cutaneous disorders such as atopic dermatitis, psoriasis, acne vulgaris, and rosacea, together with UV-induced skin injury and photoaging, are highly prevalent conditions that involve varying contributions from dysregulated immune responses, cutaneous inflammation, oxidative stress, barrier dysfunction, microbiome alteration, and exogenous injury. However, these [...] Read more.
Cutaneous disorders such as atopic dermatitis, psoriasis, acne vulgaris, and rosacea, together with UV-induced skin injury and photoaging, are highly prevalent conditions that involve varying contributions from dysregulated immune responses, cutaneous inflammation, oxidative stress, barrier dysfunction, microbiome alteration, and exogenous injury. However, these conditions are biologically heterogeneous and should not be regarded as a single mechanistic class. Sulforaphane, a naturally occurring isothiocyanate found primarily in broccoli and other cruciferous vegetables, has attracted interest in dermatology because of its antioxidant, cytoprotective, and context-dependent anti-inflammatory properties. Sulforaphane exerts its biological effects by modulating key signaling pathways, particularly the Keap1/Nrf2 pathway and, in some settings, NF-κB-related signaling, thereby reducing oxidative stress and inflammation, regulating immune responses, enhancing skin barrier function, and potentially influencing the cutaneous microbiome. Preclinical studies and limited human data suggest that sulforaphane may reduce erythema, edema, and other markers of cutaneous damage in selected settings. This comprehensive review explores the role of sulforaphane across heterogeneous cutaneous conditions, with emphasis on molecular mechanisms, disease-specific differences, current evidence, and discusses key translational constraints including formulation, delivery, lack of standardized dosing, and the limitations of cell culture and animal models for predicting human efficacy. Overall, sulforaphane should presently be regarded as a promising but still early-stage translational candidate in dermatology. Robust human efficacy data remain lacking for chronic inflammatory dermatoses such as psoriasis, atopic dermatitis, acne, and rosacea, whereas the strongest current human evidence relates to UV-associated skin outcomes and photoprotection. Full article
(This article belongs to the Special Issue Harnessing Nature’s Power: Antioxidants and Anti-Inflammatory Natural Compounds in Health and Disease)
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