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Nutritional Supplements for Alzheimer’s and Other Neurodegenerative Diseases

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Neuro Sciences".

Deadline for manuscript submissions: 25 June 2026 | Viewed by 1016

Special Issue Editors


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Guest Editor
Department of Life Science, Health and Health Professions, Link Campus University Rome, Rome, Italy
Interests: biomarkers of frailty, sarcopenia, metabolic disease, cognitive decline (early detection, multimodal interventions); geroprotective mechanisms to delay or prevent common age-related diseases

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Guest Editor
Department of Life Science, Health and Health Professions, School of Medicine Rome, Link Campus University of Rome, Rome, Italy
Interests: neuro-oncology; immunotherapy; targeted therapy; prognostic biomarkers; nutrition and cancer

Special Issue Information

Dear Colleagues,

Nutrition and nutritional supplementation in older adults have been shown to influence disease progression across a range of comorbidities. Aging and prevalent diseases in older persons, including Alzheimer’s disease (AD), share common pathophysiological mechanisms—most notably inflammaging, an age-related low-grade, systematic proinflammatory state associated with an increased risk of developing common age-related diseases.

Recent evidence suggests that dietary patterns, such as the MIND and Mediterranean diets, as well as specific nutritional supplements (e.g., vitamin D, vitamin B, ginkgo biloba, omega-3 fatty acids, etc.) hold important preventive potential for cognitive decline and AD, largely through their ability to modulate neuroinflammation.

Understanding the role of targeted nutritional strategies (dietary intervention and/or supplementation) on neurodegeneration and disease progression is essential for developing effective interventional trials, especially in individuals at the early stage of neurodegenerative disease.

Precision care approaches emphasize how the interaction between different comorbidities and neurodegenerative diseases may be influenced by nutritional status.

We invite researchers to submit original clinical research articles related to the impact of nutrition on neurodegenerative diseases and common age-related comorbidities across the aging trajectory.

Prof. Dr. Angela Marie Abbatecola
Prof. Dr. Salvatore Caponnetto
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurodegenerative disease
  • Alzheimer’s
  • neuroinflammation
  • biomarkers
  • age-related comborbidities
  • precision care

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Published Papers (1 paper)

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Research

18 pages, 1743 KB  
Article
Gut Microbiota Changes Following Short-Term Probiotic Supplementation in Older Home Enteral Nutrition Patients
by Niki Tombolesi, Emanuele Francini, Giulia Matacchione, Debora Sparvoli, Nikolina Jukic Peladic, Maurizio Cardelli, Rina Recchioni, Matilde Sbriscia, Sonia Fantone, Chiara Giordani, Angelica Giuliani, Stefania Silvi, Dennis Fiorini, Sabrina Donati Zeppa, Antonio Domenico Procopio, Fabiola Olivieri, Fabrizia Lattanzio, Maria Capalbo, Paolo Orlandoni and Francesca Marchegiani
Nutrients 2026, 18(6), 1013; https://doi.org/10.3390/nu18061013 - 23 Mar 2026
Viewed by 670
Abstract
Background: Home Enteral Nutrition (HEN) patients, often older adults, are susceptible to gut microbiota dysbiosis and low-grade chronic inflammation (inflammaging), which negatively impacts overall health and intestinal integrity. However, evidence on microbiota-targeted interventions in this population remains limited. The development of targeted nutritional [...] Read more.
Background: Home Enteral Nutrition (HEN) patients, often older adults, are susceptible to gut microbiota dysbiosis and low-grade chronic inflammation (inflammaging), which negatively impacts overall health and intestinal integrity. However, evidence on microbiota-targeted interventions in this population remains limited. The development of targeted nutritional strategies, such as probiotic supplementation, has been proposed to address these age-related changes. Methods: This exploratory randomized, open-label study explored changes in gut microbiota composition following a 30-day probiotic intervention in a cohort of sixteen older HEN patients. Gut microbiota profiles were analyzed at baseline and post-intervention using 16S rRNA gene amplicon sequencing. Results: Significant shifts in the gut microbiota were observed, including a statistically significant increase in alpha diversity after 30 days. At the taxonomic level, the treated group showed an increased relative abundance of Lachnospiraceae and Erysipelotrichaceae, suggesting a modulation of gut microbiota structure following probiotic supplementation. Conclusions: These findings provide preliminary insights into microbiota dynamics in this population and may inform the design of future studies integrating functional and clinical outcomes. Full article
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