nutrients-logo

Journal Browser

Journal Browser

Effects of Physical Activity and Nutritional Supplementation on Muscle Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Sports Nutrition".

Deadline for manuscript submissions: 20 June 2026 | Viewed by 3977

Special Issue Editor


E-Mail Website
Guest Editor
College of Health Science, University of Memphis, Memphis, TN, USA
Interests: muscle metabolism; metabolic dysfunction; cachexia; nutrition; exercise; skeletal muscle; metabolism
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to announce a call for papers for an upcoming Special Issue dedicated to exploring the effects of physical activity and nutritional supplementation on muscle health. This issue will focus on exercise and nutritional interventions, with a particular emphasis on how they contribute to muscle maintenance, growth, recovery, and overall well-being.

Muscle health is vital for mobility, quality of life, and the prevention of age-related decline. Recent advances in research have shed light on how physical activity, including strength training and aerobic exercises, coupled with strategic nutritional supplementation, can support muscle function, prevent sarcopenia, and aid in recovery from injury or illness. We invite researchers, practitioners, and experts in the fields of kinesiology, nutrition, gerontology, sports science, and clinical health to submit their latest findings.

We are particularly interested in manuscripts that address, but are not limited to, the following topics:

  • The physiological mechanisms linking physical activity and muscle adaptation;
  • The role of specific nutrients (proteins, amino acids, vitamins, and minerals) in muscle health;
  • Combined effects of exercise and supplementation on muscle performance;
  • Nutritional strategies for muscle recovery post-exercise or post-injury;
  • Impact of exercise and nutrition on muscle health in clinical settings;
  • Gender differences in the effect of physical activity and supplementation on muscle health.

We invite both original research articles and comprehensive reviews that contribute to a deeper understanding of how physical activity and nutritional supplementation can be optimized to enhance muscle health and function across the lifespan.

Dr. Melissa Puppa
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • skeletal muscle
  • nutrition
  • supplements
  • performance
  • sports nutrition
  • muscle recovery
  • sarcopenia
  • strength
  • muscle mass

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

33 pages, 1420 KB  
Review
Nutritional Supplements for Muscle Hypertrophy: Mechanisms and Morphology—Focused Evidence
by Andreea Maria Mănescu, Simona Ștefania Hangu and Dan Cristian Mănescu
Nutrients 2025, 17(22), 3603; https://doi.org/10.3390/nu17223603 - 18 Nov 2025
Viewed by 3569
Abstract
Nutritional supplementation is widely used in resistance training, yet assessment of “hypertrophy” is often confounded by body-composition surrogates. This narrative review, anchored in mechanistic plausibility, integrates trials reporting morphology-direct outcomes (ultrasound/MRI). Across 46 eligible trials, protein/essential amino acids (EAA) showed consistent benefits when [...] Read more.
Nutritional supplementation is widely used in resistance training, yet assessment of “hypertrophy” is often confounded by body-composition surrogates. This narrative review, anchored in mechanistic plausibility, integrates trials reporting morphology-direct outcomes (ultrasound/MRI). Across 46 eligible trials, protein/essential amino acids (EAA) showed consistent benefits when daily intake was <1.6 g·kg−1·day−1 or when per-meal leucine provision was <2–3 g; effects plateaued once intakes exceeded ~2.0 g·kg−1·day−1. Creatine monohydrate (3–5 g·day−1, with or without loading) produced measurable increases in muscle thickness or cross-sectional area in interventions lasting ≥8–12 weeks, mediated by enhanced training volume and quality. β-hydroxy-β-methylbutyrate (HMB, 3 g·day−1) demonstrated conditional utility during high training stress or caloric deficit, but was largely neutral in well-fed, resistance-trained cohorts. Adjuncts such as omega-3 fatty acids (1–2 g·day−1), citrulline (6–8 g pre-exercise), and collagen (10–15 g·day−1 plus vitamin C) primarily facilitated training tolerance, recovery, or connective-tissue adaptation, rather than driving hypertrophy directly. A tiered model is proposed: protein/EAA as the foundation, creatine as amplifier, HMB as conditional agent, and adjuncts as facilitators. Methodological heterogeneity, short intervention length, and inconsistent imaging protocols remain limiting factors, underscoring the need for standardized ultrasound/MRI and adequately powered, preregistered trials. Full article
Show Figures

Figure 1

Back to TopTop