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Dietary Patterns, Biomarkers, and Health Outcomes

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: 20 December 2026 | Viewed by 1234

Special Issue Editors


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Guest Editor
Neuroepidemiology Department, The Cyprus Institute of Neurology and Genetics, Nicosia 2371, Cyprus
Interests: neurodegenerative diseases; neuroepidmiology; metabolomics; lipidomics; proteomics; nutrimetabolomics; bioinformatics

E-Mail Website
Guest Editor
Neuroepidemiology Department, The Cyprus Institute of Neurology and Genetics, Nicosia 2371, Cyprus
Interests: neurology; neurodegenerative diseases; neuroepidmiology; neuromuscular; polyneuropathies

Special Issue Information

Dear Colleagues,

Understanding how dietary patterns influence human health increasingly relies on the integration of biomarkers. Rather than focusing on single nutrients, contemporary research emphasizes whole-diet approaches that capture the complexity of eating patterns—such as vegetarian, Mediterranean, Nordic or Westernized diets—shape metabolic, inflammatory and microbiome-related biomarkers that provide objective measures of physiological change. Favourable dietary patterns are consistently associated with improved lipid profiles, enhanced glycemic control, reduced chronic inflammation, improved cognition, and beneficial hormonal and microbial signatures. Conversely, diets high in processed foods, refined carbohydrates, and saturated fats correspond to biomarker profiles predicative of higher chronic disease risk. This evidence strengthens our understanding of how habitual diet contributes to disease outcomes such as CSV, diabetes, obesity, and cancer. Integrating dietary assessment with biomarker-based evaluation offers a powerful pathway toward precision nutrition and increased targeted public health strategies.

Dr. Christiana C. Christodoulou
Dr. Eleni Zamba-Papanicolaou
Guest Editors

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Keywords

  • dietary patterns
  • dietary habits
  • dietary assessments
  • health outcomes
  • dietary biomarkers
  • nutritional biomarkers
  • diseases

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Published Papers (1 paper)

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Review

13 pages, 2062 KB  
Review
Vitamin D Status and Sepsis Outcomes: A PRISMA-Compliant Umbrella Review and Meta-Analysis
by Gracia Castro-Luna, Henar Gómez Galera, Meritxell Sánchez Martínez and Cristina Gongora-Beltran
Nutrients 2026, 18(5), 869; https://doi.org/10.3390/nu18050869 - 9 Mar 2026
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Abstract
Background: Vitamin D plays an important role in immune regulation, and vitamin D deficiency has been increasingly associated with susceptibility to infection and adverse outcomes in critically ill patients. Numerous systematic reviews and meta-analyses have examined the relationship between vitamin D status, [...] Read more.
Background: Vitamin D plays an important role in immune regulation, and vitamin D deficiency has been increasingly associated with susceptibility to infection and adverse outcomes in critically ill patients. Numerous systematic reviews and meta-analyses have examined the relationship between vitamin D status, vitamin D receptor (VDR) gene polymorphisms, and sepsis; however, the evidence remains fragmented. Objective: The aim of this work was to synthesize high-level evidence on the association between vitamin D deficiency, VDR gene polymorphisms, vitamin D supplementation, and sepsis-related outcomes through a PRISMA 2020-compliant umbrella review. Methods: An umbrella review of systematic reviews and meta-analyses published between 2014 and 2025 was conducted using PubMed, PubMed Central, and journal archives. Eligible studies included adult, pediatric, and neonatal populations and evaluated sepsis incidence, mortality, disease severity, secondary outcomes, and genetic associations. Data were synthesized qualitatively due to overlap of primary studies and heterogeneity. Conceptual forest plots and funnel plots were used to summarize evidence direction and potential publication bias. Results: Nineteen systematic reviews and meta-analyses encompassing over 300 primary studies were included. Vitamin D deficiency was consistently associated with an increased risk of sepsis, higher mortality, and greater disease severity across adult and pediatric populations. Stronger associations were observed in children and neonates, including higher PRISM III scores, increased need for mechanical ventilation, and longer hospital stays. VDR gene polymorphisms were modestly but consistently associated with increased sepsis susceptibility. In contrast, vitamin D supplementation did not demonstrate a consistent reduction in sepsis risk or mortality. Conclusions: Vitamin D deficiency is a robust marker of sepsis risk, severity, and poor prognosis, whereas current evidence does not support vitamin D supplementation as an effective treatment for established sepsis. Full article
(This article belongs to the Special Issue Dietary Patterns, Biomarkers, and Health Outcomes)
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