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The Role of Berry Phytochemicals in Treating Obesity, Inflammation and Associated Comorbidities

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: 15 April 2026 | Viewed by 1023

Special Issue Editors


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Guest Editor
Department of Biotechnology and Food Microbiology, Faculty of Food Science and Nutrition, Poznan University of Life Sciences, 60-624 Poznan, Poland
Interests: functional foods; antioxidant activity; cell culture; metabolic diseases; molecular biology; adipogenesis; anti-inflammatory activity; bioactive compounds; nutrigenomics
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Biotechnology and Food Microbiology, Faculty of Food Science and Nutrition, Poznan University of Life Sciences, 60-624 Poznan, Poland
Interests: functional foods; dietary bioactive compounds; nutrigenomics; antioxidant activity; anticancer potential; chemoprevention; anti-inflammatory effects; obesity; inflammatory bowel disease; endometriosis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Chronic inflammation plays an extensive role in the development and progression of severe health disorders, including obesity, diabetes, cardiovascular disease, cancer, atherosclerosis, and neurodegenerative diseases. Therefore, therapy targeting inflammation is a promising strategy to combat inflammation-related diseases. Certain dietary bioactive compounds can prevent, alleviate, and even reverse the progression of the pathogenic inflammatory processes that underlie these diseases. Berries belong to the best dietary sources of bioactive substances, which exert multiple effects on promoting human health and preventing diseases. Findings from in vivo and in vitro studies indicate that polyphenols from berry fruits can reduce obesity-induced metabolic disorders, oxidative stress, and inflammation, and the consumption of foods rich in anthocyanins is associated with reduced risk for chronic, non-communicable diseases. Berries are beneficial for health; however, their underlying mechanisms of action in protecting against chronic diseases are likely complex and require further elucidation.

This Special Issue's scope is to indicate the potential beneficial effects of berry consumption on health, well-being, and longevity. We welcome original research articles and comprehensive reviews that discuss the most recent findings regarding the health benefits of berries in the prevention and treatment of obesity, diabetes, cardiovascular complications, and other diseases mediated by inflammatory and oxidative processes.

Dr. Katarzyna Kowalska
Dr. Anna Olejnik
Guest Editors

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • berry fruits
  • phytochemicals
  • obesity
  • anti-inflammatory effects
  • antioxidant activity
  • cardiovascular disease
  • metabolic disorders
  • diabetes
  • neurodegenerative diseases
  • cytokines
  • chemokines
  • adipokines

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Published Papers (1 paper)

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Research

16 pages, 976 KB  
Article
Immunomodulatory Effect of Raspberry (Rubus idaeus L.) Fruit Extracts on Activated Macrophages and Dysfunctional Vascular Endothelial Cells
by Katarzyna Kowalska, Radosław Dembczyński and Anna Olejnik
Nutrients 2025, 17(20), 3257; https://doi.org/10.3390/nu17203257 - 16 Oct 2025
Viewed by 788
Abstract
Background: Growing evidence highlights the beneficial effects of flavonoids, including anthocyanins, as key components in reducing cardiovascular risk, and emphasizes that incorporating anthocyanin-rich fruits into the daily diet significantly impacts public health. Methods: The effect of bioactive polyphenols from raspberry fruit (RBF) on [...] Read more.
Background: Growing evidence highlights the beneficial effects of flavonoids, including anthocyanins, as key components in reducing cardiovascular risk, and emphasizes that incorporating anthocyanin-rich fruits into the daily diet significantly impacts public health. Methods: The effect of bioactive polyphenols from raspberry fruit (RBF) on molecular pathways in inflammation was studied in activated RAW 264.7 macrophages and their protective potential against endothelial dysfunction was analyzed using TNF-α-induced human umbilical vein endothelial cells (HUVECs). Results: The results have shown that RBF extract, along with its anthocyanin and polyphenol fractions, has a significant anti-inflammatory effect in macrophage cell culture by inhibiting the LPS-induced expression of pro-inflammatory genes, including IL-6, IL-1β, TNF-α, and NF-κB. Moreover, RBF and both fractions have demonstrated a protective effect on endothelial function by decreasing the expression of several inflammation-related genes and adhesion molecules, such as IL-6, IL-1β, VCAM-1, ICAM-1, and SELE, in TNF-α-induced HUVECs. Conclusions: The consumption of RBF and/or polyphenol-rich extracts may help prevent the onset of early atherosclerosis. This is attributed to their ability to improve inflammation status and enhance vascular endothelial function. Given the strong anti-inflammatory properties of RBF, incorporating them into a daily diet could significantly reduce the risk of non-communicable diseases related to inflammation. Full article
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