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Personalized Nutrition, Obesity and Metabolic Syndrome

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 20 December 2025 | Viewed by 989

Special Issue Editor


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Guest Editor
Department of Clinical Biochemistry, The Children’s Memorial Health Institute, 04-761 Warsaw, Poland
Interests: metabolic syndrome; metabolomics; obesity; liver disease; lipoproteins; vitamins; antioxidants; non-alcoholic fatty liver disease; fatty acids; nutrition; inflammation; metabolites of the gut microbiota
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Special Issue Information

Dear Colleagues,

In Special Issue, we would like to discuss the impact of nutrients, environmental factors, and obesity, which can lead to the development of civilization diseases such as metabolic syndrome and cardio–renal–metabolic syndrome. Metabolic syndrome is a public health problem due to its close association with metabolic comorbidities such as type 2 diabetes, dyslipidemia, liver disease, cardiovascular disease and renal dysfunction. Therefore, it is very important to prepare personalized nutrition in cases of metabolic syndrome, as there is evidence that indicates that excessive or inadequate nutrient intake induces a disturbance of metabolic homeostasis through excessive secretion of various compounds, leading to alterations in metabolic pathways and systemic metabolic dysfunction. Further, nutritional interventions have become effective strategies for treating obesity and related metabolic disorders. In this Special Issue, we would like to highlight new strategies and mechanisms, as well as nutritional approaches to combat obesity and related metabolic disorders, focusing on the following topcis:

  • The impact of personalized nutrition in shaping the gut microbiota and their metabolites;
  • The impact of dietary patterns and interventions (including interventions to increase physical activity as part of personalized medicine);
  • The assessment of health-related quality of life (HRQoL) in patients with cardio–renal–metabolic syndrome;
  • The impact of physical activity on optimizing insulin resistance and dyslipidemia.

In this way, we hope to shed light on the pathogenesis of common metabolic disorders, including obesity, type 2 diabetes mellitus, non-alcoholic liver disease, and cardio–renal–metabolic syndrome.

This Special Issue of the journal Nutrients, entitled “Personalized Nutrition, Obesity and Metabolic Syndrome”, aims to solicit original research papers and review articles on the current state of research in the field, including both exploratory and preclinical studies.

Dr. Aldona Wierzbicka-Rucinska
Guest Editor

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • personalized nutrition
  • quality of life (HRQoL)
  • physical activity
  • lipid profile
  • microbiota
  • metabolites of the gut microbiota
  • cardio–renal–metabolic syndrome

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Published Papers (1 paper)

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Research

14 pages, 1365 KB  
Article
Study Protocol and Baseline Cardiometabolic Characterization of the RIO-Study (Response to an Intervention with Omega-3): A Randomized, Double-Blind, Placebo-Controlled Crossover Trial on Lipid and Inflammatory Profiles in Overweight and Obese Adults with Hypertriglyceridemia in Valdivia, Chile
by Josefina Enríquez, Consuelo Quezada, Jessica Molina, Matías Sáez, Iarela Mitre, Camila Moreira, Feren Sandoval, Rodrigo Maldonado, Montserrat Fitó, Sebastián Zagmutt, Catalina Ramírez-Contreras, Eneko Ganuza, Álvaro Hernáez, Sergio Martínez-Huenchullán and Viviana Sandoval
Nutrients 2025, 17(21), 3397; https://doi.org/10.3390/nu17213397 - 29 Oct 2025
Viewed by 725
Abstract
Background: Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide, with metabolic syndrome and its risk factors contributing substantially to cases in Latin America. In southern Chile, obesity, dyslipidemia, and sedentary behavior are highly prevalent, yet comprehensive baseline data on [...] Read more.
Background: Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide, with metabolic syndrome and its risk factors contributing substantially to cases in Latin America. In southern Chile, obesity, dyslipidemia, and sedentary behavior are highly prevalent, yet comprehensive baseline data on these factors are scarce. Establishing regional cardiometabolic profiles is crucial to inform prevention strategies. Objective: To describe the RIO-Study protocol and characterize the baseline cardiometabolic profile of adults from Valdivia, southern Chile. Methods: The RIO-Study is a randomized, double-blind, placebo-controlled, crossover clinical trial evaluating the effects of nutritional doses of seaweed-derived omega-3 fatty acids on lipid metabolism, inflammation, and molecular lipid regulators in adults with overweight/obesity. The protocol includes a standardized high-fat breakfast challenge and repeated postprandial blood sampling to assess dynamic lipid responses. Screening procedures comprised blood pressure measurement, fasting blood sampling, body composition by bioelectrical impedance, and health and lifestyle questionnaires. Results: Among screened participants, 91% presented overweight/obesity and 55% presented central adiposity, exceeding regional cardiometabolic risk thresholds (waist circumference ≥ 90 cm in men, ≥80 cm in women). Men exhibited higher waist circumference (100 ± 10.8 vs. 91.6 ± 11.9 cm), waist-to-hip ratio (0.99 ± 0.08 vs. 0.92 ± 0.07), systolic blood pressure (130 ± 12.0 vs. 122 ± 13.4 mmHg), triglycerides (168 ± 84.7 vs. 122 ± 64.9 mg/dL), VLDL-C (33.7 ± 17.2 vs. 24.4 ± 13.0 mg/dL), and sedentary time (8.1 ± 2.3 vs. 6.8 ± 2.3 h/day). Women had greater total body fat (39.7 ± 4.75% vs. 31.1 ± 5.30%), higher HDL-C (56.6 ± 13.3 vs. 46.9 ± 9.39 mg/dL), and more often had normal weight (13% vs. 0%). Conclusions: The RIO-Study provides novel insights into cardiometabolic risk and will elucidate the effects of nutritional omega-3 supplementation in a high-risk Chilean population. Full article
(This article belongs to the Special Issue Personalized Nutrition, Obesity and Metabolic Syndrome)
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