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Challenges to Limiting Sarcopenia and Age-Related Diseases to Promote Healthy Aging (2nd Edition)

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Geriatric Nutrition".

Deadline for manuscript submissions: closed (15 November 2024) | Viewed by 5388

Special Issue Editors

Dr. Dominique Meynial-Denis

E-Mail Website
Guest Editor
Human Nutrition Unit (UMR 1019) and CRNH Centre de Recherche en Nutrition Humaine d'Auvergne, Clermont-Ferrand, France
Interests: aging; sarcopenia; muscle wasting; nutrition; nuclear magnetic resonance (NMR) of nitrogen 15; carbon 13 and protons; metabolism; leucine; alanine; glutamine
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Giacomo Garibotto

E-Mail Website
Guest Editor
1. Department of Internal Medicine, Division of Nephrology, Dialysis and Transplantation, University of Genoa, Viale Benedetto 15,6, I-16132 Genoa, Italy
2. IRCCS Ospedale Policlinico San Martino, Genoa, Italy
Interests: chronic kidney disease; nutrition; diabetic nephropathy; inflammation; oxidative stress; amino acid and protein metabolism
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Progressive loss of skeletal muscle mass and strength was first defined by Rosenberg in 1997 as a hallmark of aging and has since been referred to as sarcopenia. As life expectancy continues to increase worldwide, sarcopenia has become a major public health issue. Moreover, sarcopenia, rather than being considered “a process of normative aging”, is a disease according to the International Classification of Disease, Tenth Revision, Clinical Modification (ICD-10-CM).

The impact of sarcopenia on health and well-being is broad and includes impaired function, increased morbidity, increased incidence of institutionalization, reduced quality of life and even death. Sarcopenia increases the risk of age-related diseases such as osteoporosis, obesity, type II diabetes, cardiovascular diseases, chronic kidney diseases, cachexia, physical frailty and injury, which accelerate its progression. Thus, it is important we define possible ways of promoting healthy and successful aging.

This Special Issue will highlight the challenges of sarcopenia and age-related diseases to promote healthy aging. It intends to bring together basic researchers and clinicians working in the areas of nutritional sciences, geriatrics, internal medicine and public health. Both original research and review articles will be considered suitable for inclusion in this Special Issue.

Dr. Dominique Meynial-Denis
Prof. Dr. Giacomo Garibotto
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • aging
  • sarcopenia
  • age-related diseases
  • muscle
  • healthy aging

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Published Papers (3 papers)

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16 pages, 2635 KiB  
Article
Preoperative Sarcopenia Severity and Clinical Outcomes after Total Hip Arthroplasty
by Shinya Tanaka, Azusa Kayamoto, Chiaki Terai, Shusuke Nojiri, Yuki Fugane, Tomohiro Mori, Motoki Nagaya, Masato Kako, Hiroki Iida, Yusuke Osawa, Yasuhiko Takegami and Yoshihiro Nishida
Nutrients 2024, 16(13), 2085; https://doi.org/10.3390/nu16132085 - 29 Jun 2024
Cited by 1 | Viewed by 1853
Abstract
The outcome of total hip arthroplasty (THA) in patients with end-stage arthritis of the hip is associated with preoperative physical status. This study was performed to examine the relationship between the preoperative severity of sarcopenia and clinical outcomes after THA. This retrospective cohort [...] Read more.
The outcome of total hip arthroplasty (THA) in patients with end-stage arthritis of the hip is associated with preoperative physical status. This study was performed to examine the relationship between the preoperative severity of sarcopenia and clinical outcomes after THA. This retrospective cohort study was performed among 306 consecutive patients (mean age: 63.7 ± 12.9 years, 222 women) undergoing THA at a university hospital. The severity of sarcopenia was determined based on the skeletal muscle mass index (SMI), handgrip strength, and gait speed according to the criteria of the Asian Working Group for Sarcopenia 2019. The severe sarcopenia prevalence rate was 10.6%. Severe sarcopenia was significantly associated with the risk of delayed functional recovery (adjusted odds ratio, 2.82; 95% confidence interval, 1.03–7.72; p = 0.043) compared with the non-sarcopenia group after adjusting for pre-existing risk factors, including preoperative hip function and physical activity. The addition of SMI, handgrip strength, and gait speed to the model for risk of functional recovery delay significantly increased the area under the receiver operating characteristic curve (p = 0.038). Severe sarcopenia was significantly associated with poorer hip function and patient-reported outcomes at 6 months after surgery compared with the non-sarcopenia group. Severe sarcopenia was adversely associated with postoperative clinical outcomes in patients undergoing THA. Full article
(This article belongs to the Special Issue Challenges to Limiting Sarcopenia and Age-Related Diseases to Promote Healthy Aging (2nd Edition))
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20 pages, 18102 KiB  
Article
New Perspectives for Low Muscle Mass Quantity/Quality Assessment in Probable Sarcopenic Older Adults: An Exploratory Analysis Study
by Maria Besora-Moreno, Elisabet Llauradó, Claudia Jiménez-ten Hoevel, Cristina Sepúlveda, Judit Queral, Glòria Bernal, Laura Pérez-Merino, Sergio Martinez-Hervas, Blanca Alabadi, Yolanda Ortega, Rosa Maria Valls, Rosa Solà and Anna Pedret
Nutrients 2024, 16(10), 1496; https://doi.org/10.3390/nu16101496 - 15 May 2024
Cited by 1 | Viewed by 1301
Abstract
Background: Low muscle mass quantity/quality is needed to confirm sarcopenia diagnosis; however, no validated cut-off points exist. This study aimed to determine the diagnostic accuracy of sarcopenia through muscle mass quantity/quality parameters, using the bioimpedance analysis (BIA), isokinetic, and ultrasound tools in probable [...] Read more.
Background: Low muscle mass quantity/quality is needed to confirm sarcopenia diagnosis; however, no validated cut-off points exist. This study aimed to determine the diagnostic accuracy of sarcopenia through muscle mass quantity/quality parameters, using the bioimpedance analysis (BIA), isokinetic, and ultrasound tools in probable sarcopenic community-dwelling older adults (≥60 years). Also, it aimed to suggest possible new cut-off points to confirm sarcopenia diagnosis. Methods: A cross-sectional exploratory analysis study was performed with probable sarcopenic and non-sarcopenic older adults. BIA, isokinetic, and ultrasound parameters were evaluated. The protocol was registered on ClinicalTrials.gov (NCT05485402). Results: A total of 50 individuals were included, 38 with probable sarcopenia (69.63 ± 4.14 years; 7 men and 31 women) and 12 non-sarcopenic (67.58 ± 4.54 years; 7 men and 5 women). The phase angle (cut-off: 5.10° men, p = 0.003; 4.95° women, p < 0.001), peak torque (cut-off: 66.75 Newtons-meters (N-m) men, p < 0.001; 48.35 N-m women, p < 0.001), total work (cut-off: 64.00 Joules (J) men, p = 0.007; 54.70 J women, p = 0.001), and mean power (cut-off: 87.8 Watts (W) men, p = 0.003; 48.95 W women, p = 0.008) in leg extension, as well as the the forearm muscle thickness (cut-off: 1.41 cm (cm) men, p = 0.017; 0.94 cm women, p = 0.041), had great diagnostic accuracy in both sexes. Conclusions: The phase angle, peak torque, total work, and mean power in leg extension, as well as forearm muscle thickness, had great diagnostic accuracy in regard to sarcopenia, and the suggested cut-off points could lead to the confirmation of sarcopenia diagnosis, but more studies are needed to confirm this. Full article
(This article belongs to the Special Issue Challenges to Limiting Sarcopenia and Age-Related Diseases to Promote Healthy Aging (2nd Edition))
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Other

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23 pages, 1252 KiB  
Systematic Review
The Relationship Between Gut Microbiota, Muscle Mass and Physical Function in Older Individuals: A Systematic Review
by David J. Barry, Sam S. X. Wu and Matthew B. Cooke
Nutrients 2025, 17(1), 81; https://doi.org/10.3390/nu17010081 - 28 Dec 2024
Cited by 1 | Viewed by 1654
Abstract
Background: Recent evidence suggests that sarcopenia and subsequent changes in muscle mass and functional outcomes are linked to disruption to the gastrointestinal microbiota composition and/or function via the microbiota-gut-muscle axis. Despite growing interest, few studies have systemically analysed (1) the relationship between the [...] Read more.
Background: Recent evidence suggests that sarcopenia and subsequent changes in muscle mass and functional outcomes are linked to disruption to the gastrointestinal microbiota composition and/or function via the microbiota-gut-muscle axis. Despite growing interest, few studies have systemically analysed (1) the relationship between the gut microbiota, muscle mass and physical performance and (2) the effects of gut-modulating dietary interventions on these outcomes within older individuals with or without sarcopenia. Methods: Four electronic databases (PubMed, MEDLINE, Embase and Scopus) were searched for articles published from the year 2004 until July 2023. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) were followed. Revised Cochrane Risk of Bias (RoB 2.0) and Joanna Briggs Institute (JBI) critical appraisal checklist were utilised to evaluate the risk of bias within intervention and observational studies, respectively. Results: A total of 20 studies (14 observational and 6 interventional) involving 4071 older participants (mean age 69.9 years, 51.6% female) were included. There was significant heterogeneity regarding interventions and outcome measures used in these studies. Correlations between microbiota diversity and composition and sarcopenia-related functional outcomes were observed. Interventional studies targeting the gut microbiota resulted in improved muscle strength, body composition or physical function in some, but not all, studies. Conclusions: Despite limitations in the studies reviewed, the findings provide further evidence that the development of sarcopenia is likely influenced by an altered gut microbial environment and that interventions targeting the microbiome could hold therapeutic potential for the treatment or management of sarcopenia. Full article
(This article belongs to the Special Issue Challenges to Limiting Sarcopenia and Age-Related Diseases to Promote Healthy Aging (2nd Edition))
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