Nutritional Impacts on Metabolic Aging, Cognitive Decline, and Mortality Among Older Adults
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Geriatric Nutrition".
Deadline for manuscript submissions: 15 October 2026 | Viewed by 118
Special Issue Editor
Interests: aging; determinants of frailty and health; atherosclerosis; Mediterranean diet; cognitive decline
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Age-related physiological changes, including alterations in energy metabolism, body composition, appetite regulation, gut microbiota, and nutrient absorption, predispose older individuals to undernutrition and qualitative dietary imbalances. These nutritional disturbances contribute to metabolic dysregulation, chronic low-grade inflammation (“inflammaging”), sarcopenia, frailty progression, and increased vulnerability to cognitive decline and dementia.
Accumulating evidence suggests that dietary patterns, nutrient quality, and nutritional status play a crucial role in modulating the mechanisms of metabolic aging and neurodegeneration. Adequate nutrition may influence insulin sensitivity, mitochondrial function, oxidative stress, vascular health, and neuroinflammatory pathways, thereby impacting functional capacity, quality of life, and mortality risk. Conversely, malnutrition and poor dietary quality are consistently associated with adverse clinical outcomes, including hospitalization, disability, accelerated cognitive deterioration, and reduced survival.
This Special Issue aims to explore the multidimensional role of nutrition in shaping health trajectories during aging, with particular emphasis on metabolic aging processes, cognitive decline, dementia risk, frailty, and mortality among older adults. We welcome original research articles, clinical studies, epidemiological investigations, systematic reviews, and translational contributions that address the nutritional determinants of healthy longevity and resilience in later life.
By integrating nutritional science with gerontology, metabolism, and cognitive health research, this Special Issue seeks to advance the current knowledge of the evidence-based strategies capable of improving quality of life, functional independence, and survival outcomes in aging populations.
Dr. Cristiano Capurso
Guest Editor
Manuscript Submission Information
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Keywords
- nutrition
- diet
- quality of life
- aging
- elderly
- frailty
- cognitive decline
- dementia
- mortality
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