Nutrients

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Special Issue Editor

Prof. Dr. Yi-Chia Huang

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Guest Editor

Department of Nutrition, Chung Shan Medical University, Taichung 40201, Taiwan
Interests: oxidative stress; antioxidant capacity and nutrition; critical care and nutrition

Special Issue Information

Dear Colleagues,

High oxidative stress and increased inflammatory responses might have potential adverse impacts on human health, and further lead to disease development. Adequate antioxidant capacities are thus indispensable for humans to overcome the threats of high oxidative stress and inflammation, and further prevent or slow disease progression.

Glutathione (GSH) is a thiol and tripeptide molecule synthesized using cysteine, glycine, and glutamate in the liver. The thiol group of cysteine is a major limiting substrate for the GSH synthesis within cells. GSH and its related enzymes (i.e., glutathione peroxidase and glutathione S-transferase) constitute an important endogenous antioxidant system in the human body. Glutathione peroxidase acts as the first line of the antioxidant defense system, while GSH and glutathione S-transferase are situated in the second line. In addition, GSH might have an anti-inflammatory role in different diseases. Consequently, GSH and its related antioxidant enzymes might have important roles in human health and disease. However, the influences of GSH and its related antioxidant enzymes on human health and disease have not been deeply investigated.

This Special Issue, entitled “Glutathione and Its Related Enzymes in Health and Diseases”, will focus on the role of GSH and its related antioxidant enzymes in human health and all kinds of disease. We are interested in exploring how GSH and its related antioxidant enzymes regulate oxidative stress or inflammatory responses before, during and after disease development. In addition, any factors affecting GSH and its related antioxidant enzyme capacities will be also discussed in this Special Issue.

Prof. Dr. Yi-Chia Huang
Guest Editor

Manuscript Submission Information

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Keywords

glutathione
glutathione peroxidase
glutathione S-transferase
oxidative stress
antioxidant capacity
inflammation
health and diseases

Published Papers (1 paper)

Research

11 pages, 611 KiB

Open AccessArticle

Oxidative Stress Induced by Chemotherapy: Evaluation of Glutathione and Its Related Antioxidant Enzyme Dynamics in Patients with Colorectal Cancer

by Feng-Fan Chiang, Shih-Chien Huang, Pei-Ting Yu, Te-Hsin Chao and Yi-Chia Huang

Nutrients 2023, 15(24), 5104; https://doi.org/10.3390/nu15245104 - 14 Dec 2023

Cited by 2 | Viewed by 1047

Abstract

One of the mechanisms of chemotherapy is to increase the oxidative stress of cancer cells, leading to their apoptosis. Glutathione (GSH) and its related antioxidant enzymes might be stimulated to cope with increased oxidative stress during chemotherapy. Here, we studied the fluctuation in oxidative stress and GSH-related antioxidant capacities before tumor resection, after tumor resection, and after resection either with or without chemotherapy in patients with colorectal cancer (CRC). This was a cross-sectional and follow-up design. We followed patients before having tumor resection (pre-resection), one month after tumor resection (post-resection), and after the first scheduled chemotherapy (post-chemo). If patients were required to receive chemotherapy after tumor resection, they were assigned to the chemotherapy group. Eligible patients were scheduled to undergo six to twelve cycles of chemotherapy at 2-week intervals and received single, double, or triple chemotherapeutic drugs as required. Those patients who did not require chemotherapy were assigned to the non-chemotherapy group. Indicators of oxidative stress and GSH-related antioxidant capacities were determined at the above three time points. We found in 48 patients of the chemotherapy group and in 43 patients of the non-chemotherapy group different fluctuations in levels of oxidative stress indicators and GSH-related antioxidant capacities starting from pre-resection, post-resection through the post-chemo period. Both groups showed significantly or slightly increased levels of advanced oxidation protein products (AOPP), GSH, and its related enzymes in tumor tissues compared to adjacent normal tissues. Patients in the chemotherapy group had significantly lower plasma levels of GSH and glutathione disulfide (GSSG), but had significantly higher plasma glutathione peroxidase and glutathione reductase activities than patients in the non-chemotherapy group post-chemo. Plasma levels of malondialdehyde and AOPP were positively or negatively associated with GSH and GSSG levels post-chemo after adjustment for age, sex, and histological grading in patients receiving chemotherapy. These significant associations were, however, not seen in patients without chemotherapy. Patients with CRC may require higher GSH demands to cope with a greater oxidative stress resulting from chemotherapy. Full article

(This article belongs to the Special Issue Glutathione and Its Related Enzymes in Health and Diseases)

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