Special Issue "Advanced Nanomaterials for LSPR and SERS Applications"

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Nanophotonics Materials and Devices".

Deadline for manuscript submissions: 31 May 2023 | Viewed by 2001

Special Issue Editors

Institute of Biophotonics, National Yang Ming Chiao Tung University, Taipei 112, Taiwan
Interests: SERS; LSPR; optofluidics; biosensor; nanomanipulation
Department of Electrical Engineering, National Taiwan University, Taipei 106, Taiwan
Interests: Bio-MEMS; optical-MEMS; microfluidics; biosensing; cell manipulation in microenvironment; micro/nano fabrication techniques
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Special Issue Information

Dear Colleagues,

Surface-enhanced Raman spectroscopy (SERS) and localized surface plasmon resonance (LSPR) have both been used to provide highly sensitive detection of molecules. Like surface plasmon resonance (SPR) sensors, LSPR sensors, which are usually based on metallic nanoparticles or nanostructured substrates, detect molecular binding based on changes in refractive index. On the other hand, SERS is a technique that can provide spectral fingerprint of molecules and can thus be used to identify molecules. The enhancement effects of SERS substrates mainly come form the LSPR effects of metallic nanoparticles or nanostructures. Therefore, nanomaterials play important roles in both LSPR and SERS detection of molecules. The plasmonic properties, the surface properties, the morphologies, and the arrangement of nanomaterials can all affect the sensitivity and the reproducibility of the detection results. The LSPR effect of metallic nanoparticles is highly dependent on the size, the shape, and the material of nanoparticles. The surface properties of nanoparticles can affect the functionalization of nanoparticles, the storage stability, the nonspecific binding, the molecular adsorption, and the biocompatibility. A variety of metallic nanomaterials have been synthesized and fabricated for LSPR and SERS applications, and other nanomaterials such as graphene and carbon nanotubes have also been used in these applications to improve the detection performance. It should be noted that in addition to the synthesis of nanomaterials, the arrangement and the functionalization of nanomaterials can also have a significant impact on detection.

This Special Issue focuses on the recent progress in the design and application of nanomaterials for LSPR and SERS applications. Potential topics include, but are not limited to, the following:

  • Nanomaterials that can be used as SERS and LSPR substrates;
  • Nanomaterials that can be used to enhance the detection performance (sensitivity, specificity, etc.) of LSPR and SERS sensors;
  • Nanomaterials that can be used for sample preparation in LSPR and SERS applications;
  • Nanomaterials that can be used as Raman nanoprobes;
  • Nanomaterials that can be used to capture target molecules for LSPR and SERS sensing;
  • Synthesis, assembly, and functionalization of nanomaterials for SERS and LSPR applications.

We are pleased to invite the community to submit manuscripts to be considered for publication in this Special Issue of Nanomaterials. Original research papers, both experimental and theoretical, and review articles are welcome. We look forward to your participation.

Dr. Yih-Fan Chen
Dr. Nien-Tsu Huang
Guest Editors

Manuscript Submission Information

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Keywords

  • nanomaterial synthesis and application
  • assembly and functionalization of nanomaterials
  • surface-enhanced raman spectroscopy (SERS)
  • localized surface plasmon resonance (LSPR)
  • plasmonics
  • nanoparticles, nanocomposites, and nanostructures
  • graphene
  • carbon nanotubes
  • chemical sensors

Published Papers (2 papers)

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Research

Article
Multifunctional Plasmon-Tunable Au Nanostars and Their Applications in Highly Efficient Photothermal Inactivation and Ultra-Sensitive SERS Detection
Nanomaterials 2022, 12(23), 4232; https://doi.org/10.3390/nano12234232 - 28 Nov 2022
Cited by 2 | Viewed by 668
Abstract
The development and application in different fields of multifunctional plasmonic nanoparticles (NPs) have always been research hotspots. Herein, multi-tip Au nanostars (NSs) with an anisotropic structure were fabricated for the photothermal therapy (PTT) of bacteria and surface-enhanced Raman scattering (SERS) detection of pollutants. [...] Read more.
The development and application in different fields of multifunctional plasmonic nanoparticles (NPs) have always been research hotspots. Herein, multi-tip Au nanostars (NSs) with an anisotropic structure were fabricated for the photothermal therapy (PTT) of bacteria and surface-enhanced Raman scattering (SERS) detection of pollutants. The size and localized surface plasmon resonance (LSPR) characteristics of Au NSs were adjusted by varying Au seed additions. In addition, photothermal conversion performance of Au NSs with various Au seed additions was evaluated. Photothermal conversion efficiency of Au NSs with optimal Au seed additions (50 μL) was as high as 28.75% under 808 nm laser irradiation, and the heat generated was sufficient to kill Staphylococcus aureus (S. aureus). Importantly, Au NSs also exhibited excellent SERS activity for the 4-mercaptobenzoic acid (4-MBA) probe molecule, and the local electromagnetic field distribution of Au NSs was explored through finite-difference time-domain (FDTD) simulation. As verified by experiments, Au NSs’ SERS substrate could achieve a highly sensitive detection of a low concentration of potentially toxic pollutants such as methylene blue (MB) and bilirubin (BR). This work demonstrates a promising multifunctional nanoplatform with great potential for efficient photothermal inactivation and ultra-sensitive SERS detection. Full article
(This article belongs to the Special Issue Advanced Nanomaterials for LSPR and SERS Applications)
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Article
Lithographic SERS Aptasensor for Ultrasensitive Detection of SARS-CoV-2 in Biological Fluids
Nanomaterials 2022, 12(21), 3854; https://doi.org/10.3390/nano12213854 - 01 Nov 2022
Cited by 1 | Viewed by 895
Abstract
In this paper, we propose a technology for the rapid and sensitive detection of the whole viral particles of SARS-CoV-2 using double-labeled DNA aptamers as recognition elements together with the SERS method for detecting the optical response. We report on the development of [...] Read more.
In this paper, we propose a technology for the rapid and sensitive detection of the whole viral particles of SARS-CoV-2 using double-labeled DNA aptamers as recognition elements together with the SERS method for detecting the optical response. We report on the development of a SERS-aptasensor based on a reproducible lithographic SERS substrate, featuring the combination of high speed, specificity, and ultrasensitive quantitative detection of SARS-CoV-2 virions. The sensor makes it possible to identify SARS-CoV-2 in very low concentrations (the limit of detection was 100 copies/mL), demonstrating a sensitivity level comparable to the existing diagnostic golden standard—the reverse transcription polymerase chain reaction. Full article
(This article belongs to the Special Issue Advanced Nanomaterials for LSPR and SERS Applications)
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