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Nanomaterials
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Nanomaterials in Biomedicine
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Nanomaterials in Biomedicine

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 6340

Special Issue Editor

Dr. Miryana Hémadi

E-Mail Website
Guest Editor
ITODYS Laboratory, Chemistry Department, Université de Paris, 75013 Paris, France
Interests: synthesis and elaboration of multifunctional nanomaterials; magnetic and optical nanoparticles; surface modification and functionalization; interaction with biomolecules; thermal therapies (photothermia and magnetic hyperthermia); nanomedecine; heavy-metal and polluant extraction; water decontamination; magnetic harvesting; biodegradation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The advent of nanotechnology and especially nanomedicine has opened up new possibilities for diagnosis and treatment of many diseases. Due to their size and surface properties, nanomaterials have the potential to overcome physiological barriers.

In this Special Issue, we are interested in several classes of hybrid nanomaterials (inorganic and organic) for theranostics. The excellent physical and chemical properties of these nanomaterials, as well as their low toxicity, mean that they can be exploited for a wide variety of biomedical applications. Functionalization of these nanomaterials increases their efficacy and specificity. In nanomedecine, this is achieved by binding proteins or other biomolecules to their surface.

Your participation in the present Special Issue on “Nanomaterials in Biomedicine” will allow us to explore the latest advances in the field. This Special Issue will cover the elaboration of hybrid nanomaterials for biomedical application. 

Dr. Miryana Hémadi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inorganic and organic nanoparticles
  • synthesis and elaboration of nanomaterials
  • functionalization and surface modification
  • thermal therapies
  • bioimaging, biosensors
  • biomedical applications
  • nanobiotechnology
  • cancer diseases
  • bacterial infections
  • biofilm

Published Papers (4 papers)

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Research

16 pages, 4115 KiB  
Article
Gold and Iron Oxide Nanoparticle Assemblies on Turnip Yellow Mosaic Virus for In-Solution Photothermal Experiments
by Ha Anh Nguyen, Sendos Darwish, Hong Nam Pham, Souad Ammar and Nguyet-Thanh Ha-Duong
Nanomaterials 2023, 13(18), 2509; https://doi.org/10.3390/nano13182509 - 07 Sep 2023
Cited by 1 | Viewed by 1078
Abstract
The ability to construct three-dimensional architectures via nanoscale engineering is important for emerging applications in sensors, catalysis, controlled drug delivery, microelectronics, and medical diagnostics nanotechnologies. Because of their well-defined and highly organized symmetric structures, viral plant capsids provide a 3D scaffold for the [...] Read more.
The ability to construct three-dimensional architectures via nanoscale engineering is important for emerging applications in sensors, catalysis, controlled drug delivery, microelectronics, and medical diagnostics nanotechnologies. Because of their well-defined and highly organized symmetric structures, viral plant capsids provide a 3D scaffold for the precise placement of functional inorganic particles yielding advanced hierarchical hybrid nanomaterials. In this study, we used turnip yellow mosaic virus (TYMV), grafting gold nanoparticles (AuNP) or iron oxide nanoparticles (IONP) onto its outer surface. It is the first time that such an assembly was obtained with IONP. After purification, the resulting nano-biohybrids were characterized by different technics (dynamic light scattering, transmission electron microcopy, X-ray photoelectron spectroscopy…), showing the robustness of the architectures and their colloidal stability in water. In-solution photothermal experiments were then successfully conducted on TYMV-AuNP and TYMV-IONP, the related nano-biohybrids, evidencing a net enhancement of the heating capability of these systems compared to their free NP counterparts. These results suggest that these virus-based materials could be used as photothermal therapeutic agents. Full article
(This article belongs to the Special Issue Nanomaterials in Biomedicine)
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18 pages, 3753 KiB  
Article
Lamivudine and Zidovudine-Loaded Nanostructures: Green Chemistry Preparation for Pediatric Oral Administration
by Marina D. V. Guedes, Morgana S. Marques, Simone J. Berlitz, Murilo H. M. Facure, Daniel S. Correa, Clarice Steffens, Renata V. Contri and Irene C. Külkamp-Guerreiro
Nanomaterials 2023, 13(4), 770; https://doi.org/10.3390/nano13040770 - 18 Feb 2023
Cited by 3 | Viewed by 1416
Abstract
Here, we report on the development of lipid-based nanostructures containing zidovudine (1 mg/mL) and lamivudine (0.5 mg/mL) for oral administration in the pediatric population, eliminating the use of organic solvents, which is in accordance with green chemistry principles. The formulations were obtained by [...] Read more.
Here, we report on the development of lipid-based nanostructures containing zidovudine (1 mg/mL) and lamivudine (0.5 mg/mL) for oral administration in the pediatric population, eliminating the use of organic solvents, which is in accordance with green chemistry principles. The formulations were obtained by ultrasonication using monoolein (MN) or phytantriol (PN), which presented narrow size distributions with similar mean particle sizes (~150 nm) determined by laser diffraction. The zeta potential and the pH values of the formulations were around −4.0 mV and 6.0, respectively. MN presented a slightly higher incorporation rate compared to PN. Nanoemulsions were obtained when using monoolein, while cubosomes were obtained when using phytantriol, as confirmed by Small-Angle X-ray Scattering. The formulations enabled drug release control and protection against acid degradation. The drug incorporation was effective and the analyses using an electronic tongue indicated a difference in palatability between the nanotechnological samples in comparison with the drug solutions. In conclusion, PN was considered to have the strongest potential as a novel oral formulation for pediatric HIV treatment. Full article
(This article belongs to the Special Issue Nanomaterials in Biomedicine)
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12 pages, 3743 KiB  
Article
New Conjugates Based on AIS/ZnS Quantum Dots and Aluminum Phthalocyanine Photosensitizer: Synthesis, Properties and Some Perspectives
by Dmitry Yakovlev, Ekaterina Kolesova, Svetlana Sizova, Kirill Annas, Marina Tretyak, Victor Loschenov, Anna Orlova and Vladimir Oleinikov
Nanomaterials 2022, 12(21), 3874; https://doi.org/10.3390/nano12213874 - 02 Nov 2022
Cited by 1 | Viewed by 1492
Abstract
Today, fluorescent diagnostics and photodynamic therapy are promising methods for diagnosing and treating oncological diseases. The development of new photosensitizers (PS) is one of the most important tasks to improve the efficiency of both laser-induced diagnostics and therapy. In our study, we conjugated [...] Read more.
Today, fluorescent diagnostics and photodynamic therapy are promising methods for diagnosing and treating oncological diseases. The development of new photosensitizers (PS) is one of the most important tasks to improve the efficiency of both laser-induced diagnostics and therapy. In our study, we conjugated PS with AIS/ZnS triple quantum dots (QDs) to obtain non-aggregated complexes. It was shown that the conjugation of PS with QDs does not change the PS fluorescence lifetime, which is a marker of the preservation of PS photophysical properties. In particular, efficient resonant Förster energy transfer (FRET), from QDs to PS molecules in the conjugate, increases the PS luminescence response. The FRET from QD to PS molecules with different ratios of donor and acceptors are shown. It has been demonstrated that the average efficiency of FRET depends on the ratio of PS and QD and reaches a maximum value of 80% at a ratio of 6 PS molecules per 1 QD molecule. Thus, these studies could help to contribute to the development of new complexes based on QD and PS to improve the efficiency of phototheranostics. Full article
(This article belongs to the Special Issue Nanomaterials in Biomedicine)
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19 pages, 2842 KiB  
Article
Mesoporous Silica and Oligo (Ethylene Glycol) Methacrylates-Based Dual-Responsive Hybrid Nanogels
by Micaela A. Macchione, Dariana Aristizábal Bedoya, Eva Rivero-Buceta, Pablo Botella and Miriam C. Strumia
Nanomaterials 2022, 12(21), 3835; https://doi.org/10.3390/nano12213835 - 30 Oct 2022
Cited by 1 | Viewed by 1582
Abstract
Polymeric-inorganic hybrid nanomaterials have emerged as novel multifunctional platforms because they combine the intrinsic characteristics of both materials with unexpected properties that arise from synergistic effects. In this work, hybrid nanogels based on mesoporous silica nanoparticles, oligo (ethylene glycol) methacrylates, and acidic moieties [...] Read more.
Polymeric-inorganic hybrid nanomaterials have emerged as novel multifunctional platforms because they combine the intrinsic characteristics of both materials with unexpected properties that arise from synergistic effects. In this work, hybrid nanogels based on mesoporous silica nanoparticles, oligo (ethylene glycol) methacrylates, and acidic moieties were developed employing ultrasound-assisted free radical precipitation/dispersion polymerization. Chemical structure was characterized by infrared spectroscopy and nuclear magnetic resonance. Hydrodynamic diameters at different temperatures were determined by dynamic light scattering, and cloud point temperatures were determined by turbidimetry. Cell viability in fibroblast (NIH 3T3) and human prostate cancer (LNCaP) cell lines were studied by a standard colorimetric assay. The synthetic approach allows covalent bonding between the organic and inorganic components. The composition of the polymeric structure of hybrid nanogels was optimized to incorporate high percentages of acidic co-monomer, maintaining homogeneous nanosized distribution, achieving appropriate volume phase transition temperature values for biomedical applications, and remarkable pH response. The cytotoxicity assays show that cell viability was above 80% even at the highest nanogel concentration. Finally, we demonstrated the successful cell inhibition when they were treated with camptothecin-loaded hybrid nanogels. Full article
(This article belongs to the Special Issue Nanomaterials in Biomedicine)
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