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Nanomaterials
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Synthesis and Characterization of Nanomaterials for Advanced Tissue Engineering Applications
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Synthesis and Characterization of Nanomaterials for Advanced Tissue Engineering Applications

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 10304

Special Issue Editor

Dr. Eleana Kontonasaki

E-Mail Website
Guest Editor
Department of Prosthodontics, School of Dentistry, Faculty of Health Sciences, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece
Interests: dentistry; glass ceramics; glass science and technology; glass chemistry; ceramics; sol-gel; composites; implant dentistry; restorative dentistry; esthetic dentistry; fixed prosthodontics; aesthetic dentistry; dental materials; implant dentistry, bone grafts and related treatments; materials; coating; mechanical properties; material characterization; materials processing; composite material; advanced materials; tissue regeneration; microstructure; ceramic materials; material characteristics; nanomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In the last few years, nanotechnology has come to play a significant role in various biomedical applications. Nanomaterials can exhibit unique structural, chemical, mechanical, magnetic, electrical, bioactive and biological properties, and can be used as delivery agents that release their cargo into target tissues. Monitoring the complicated biological events through the targeted delivery and release of active molecules (growth factors, genes, cytokines, etc.) is essential for the development and survival of functionally engineered tissues. Metallic, organic, inorganic and polymeric nanostructures, such as mesoporous and bioactive glass nanoparticles, dendrimers, micelles, and liposomes, are frequently considered as target-specific drug delivery systems. Tailoring the textural, physicochemical and biological characteristics of nanomaterials through continuously emerging and versatile synthesis routes, cardiac, neural, vascular, cartilaginous, dental, craniofacial and bone engineered tissues can be developed. Thus, it would be of great interest to collect within this Special Issue research, reviews, or communication manuscripts related to novel nanotechnology achievements, aiming towards different nanomaterials’ synthesis and characterization, for promising tissue engineering applications.

Dr. Eleana Kontonasaki
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • drug delivery
  • tissue engineering
  • tissue regeneration
  • smart multifunctional nanoparticles, advanced synthesis
  • soft tissue
  • hard tissue
  • cell differentiation
  • clinical applications

Published Papers (3 papers)

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Research

27 pages, 3690 KiB  
Article
Electrospun PLGA Membranes with Incorporated Moxifloxacin-Loaded Silica-Based Mesoporous Nanocarriers for Periodontal Regeneration
by Georgia K. Pouroutzidou, Maria Lazaridou, Chrysanthi Papoulia, Ioannis Tsamesidis, Konstantinos Chrissafis, George Vourlias, Konstantinos M. Paraskevopoulos, Dimitrios Bikiaris and Eleana Kontonasaki
Nanomaterials 2022, 12(5), 850; https://doi.org/10.3390/nano12050850 - 2 Mar 2022
Cited by 15 | Viewed by 3728
Abstract
Engineered electrospun membranes have emerged as promising materials in guided tissue regeneration, as they provide an appropriate framework for the formation of new functional periodontal tissues. The development of multifunctional local drug delivery systems with sustained release of drugs for prolonged infection control [...] Read more.
Engineered electrospun membranes have emerged as promising materials in guided tissue regeneration, as they provide an appropriate framework for the formation of new functional periodontal tissues. The development of multifunctional local drug delivery systems with sustained release of drugs for prolonged infection control can be used in periodontal surgical interventions to simultaneously prohibit epithelium downgrowth and ensure proper healing and regeneration of damaged periodontal tissues. The aim of the present study was the fabrication of novel composite membranes from PLGA/moxifloxacin-loaded mesoporous nanocarriers through electrospinning and the evaluation of their drug release profiles. The addition of moxifloxacin-loaded mesoporous nanocarriers in PLGA yielded a sustained and prolonged drug release, while maintaining satisfactory mechanical strength. The freshly fabricated membranes were found to be biocompatible at masses less than 1 mg after exposure to healthy erythrocytes. Increase in the amount of polymer led to more uniform fibers with large diameters and pores. The study of the parameters of the electrospinning process indicated that increase in the applied voltage value and rotation speed of the collector led to more uniform fibers with higher diameter and larger pores, suitable for tissue regeneration applications, such as periodontal tissue regeneration. Full article
(This article belongs to the Special Issue Synthesis and Characterization of Nanomaterials for Advanced Tissue Engineering Applications)
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15 pages, 3570 KiB  
Article
SBA-15 Mesoporous Silica as Delivery Vehicle for rhBMP-2 Bone Morphogenic Protein for Dental Applications
by Dimitrios Gkiliopoulos, Ioannis Tsamesidis, Anna Theocharidou, Georgia K. Pouroutzidou, Evi Christodoulou, Evangelia Stalika, Konstantinos Xanthopoulos, Dimitrios Bikiaris, Konstantinos Triantafyllidis and Eleana Kontonasaki
Nanomaterials 2022, 12(5), 822; https://doi.org/10.3390/nano12050822 - 28 Feb 2022
Cited by 11 | Viewed by 2979
Abstract
(1) Background: A proposed approach to promote periodontal tissue regeneration in cases of peri-implantitis is the local administration of growth factors at the implant site. Recombinant human bone morphogenetic protein-2 (rh-BMP-2) can effectively promote bone regeneration and osseointegration and the development of appropriate [...] Read more.
(1) Background: A proposed approach to promote periodontal tissue regeneration in cases of peri-implantitis is the local administration of growth factors at the implant site. Recombinant human bone morphogenetic protein-2 (rh-BMP-2) can effectively promote bone regeneration and osseointegration and the development of appropriate carriers for its delivery is of paramount importance. The aim of the present study was to develop SBA-15 mesoporous nanoparticles (MSNs) with varying porosity, evaluate their biocompatibility with human Periodontal Ligament Cells (hPDLCs) and to investigate their effectiveness as carriers of rh-BMP-2. (2) Methods: SBA-15 type mesoporous silicas were synthesized via sol–gel reaction. The calcined SBA-15 samples were characterized by N2 porosimetry, Fourier transform–infrared spectrometry (FTIR), Scanning (SEM) and Transmission Electron Microscopy (TEM). Rh-BMP-2 loading and release kinetics were evaluated by UV spectroscopy. (3) Results: MSNs presented hexagonally arranged, tubular pores of varying length and diameter. Slightly higher loading capacity was achieved for SBA-15 with large pores that presented good hemocompatibility. MTT assay revealed no cytotoxic effects for all the tested materials, while SBA-15 with large pores induced a significant upregulation of cell viability at day 5. (4) Conclusions: SBA-15 MSNs may prove a valuable delivery platform towards the effective release of bone-inducing proteins. Full article
(This article belongs to the Special Issue Synthesis and Characterization of Nanomaterials for Advanced Tissue Engineering Applications)
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21 pages, 4112 KiB  
Article
Effect of Artemisinin-Loaded Mesoporous Cerium-Doped Calcium Silicate Nanopowder on Cell Proliferation of Human Periodontal Ligament Fibroblasts
by Ioannis Tsamesidis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Evgenia Lymperaki, Chrysanthi Papoulia, Karine Reybier, Pierre Perio, Konstantinos M. Paraskevopoulos, Eleana Kontonasaki and Anna Theocharidou
Nanomaterials 2021, 11(9), 2189; https://doi.org/10.3390/nano11092189 - 26 Aug 2021
Cited by 16 | Viewed by 2788
Abstract
Ion doping has rendered mesoporous structures important materials in the field of tissue engineering, as apart from drug carriers, they can additionally serve as regenerative materials. The purpose of the present study was the synthesis, characterization and evaluation of the effect of artemisinin [...] Read more.
Ion doping has rendered mesoporous structures important materials in the field of tissue engineering, as apart from drug carriers, they can additionally serve as regenerative materials. The purpose of the present study was the synthesis, characterization and evaluation of the effect of artemisinin (ART)-loaded cerium-doped mesoporous calcium silicate nanopowders (NPs) on the hemocompatibility and cell proliferation of human periodontal ligament fibroblasts (hPDLFs). Mesoporous NPs were synthesized in a basic environment via a surfactant assisted cooperative self-assembly process and were characterized using Scanning Electron Microscopy (SEM), X-ray Fluorescence Spectroscopy (XRF), Fourier Transform Infrared Spectroscopy (FT-IR), X-ray Diffraction Analysis (XRD) and N2 Porosimetry. The loading capacity of NPs was evaluated using Ultrahigh Performance Liquid Chromatography/High resolution Mass Spectrometry (UHPLC/HRMS). Their biocompatibility was evaluated with the MTT assay, and the analysis of reactive oxygen species was performed using the cell-permeable ROS-sensitive probe 2′,7′-dichlorodihydrofluorescein diacetate (H2DCFDA). The synthesized NPs presented a mesoporous structure with a surface area ranging from 1312 m2/g for undoped silica to 495 m2/g for the Ce-doped NPs, excellent bioactivity after a 1-day immersion in c-SBF, hemocompatibility and a high loading capacity (around 80%). They presented ROS scavenging properties, and both the unloaded and ART-loaded NPs significantly promoted cell proliferation even at high concentrations of NPs (125 μg/mL). The ART-loaded Ce-doped NPs with the highest amount of cerium slightly restricted cell proliferation after 7 days of culture, but the difference was not significant compared with the control untreated cells. Full article
(This article belongs to the Special Issue Synthesis and Characterization of Nanomaterials for Advanced Tissue Engineering Applications)
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