Genotoxicity of Nanomaterials
A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".
Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 12011
Special Issue Editor
Interests: environmental genomics and mutagenesis; nanotoxicology; DNA damage and repair; ancient and damaged DNAs; applied genetics to genotoxicity and cancerogenicity of micro(nano) particles/plastics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In the last ten years, we have participated in a nanotechnology revolution, characterized by an enormous increase in the production, development, and commercialization of different types of nanomaterials for applications in engineering, chemistry, physics, biology, medicine, and numerous fields of industrial production. This remarkable spread of nanomaterials is accompanied by an enormous risk of human exposure and their release into the environment. The genotoxic effect of nanomaterials can be caused by direct interaction with DNA molecules and chromatin, as well as by an indirect mechanism. In this case, the "main actors" are the oxidative stress or inflammation processes and related molecules involved. Nanomaterials can affect not only our genome but also our epigenome. To date, some nanomaterials seem to induce an altered expression of genes involved in DNA methylation mechanisms, leading to global DNA methylation changes in cells in vitro and in vivo.
We are interested in original research as well as review articles that explore all aspects of the genotoxic and epigenetic effects of various nanomaterials used in biology and nanomedicine and dispersed in the environment. Potential topics include, but are not limited to, the following:
- Cellular and molecular mechanisms of genotoxic and epigenetic responses to nanomaterials (in vitro and in vivo systems);
- Genotoxic and/or epigenetic responses of humans, animals, and plants to nanoparticles and nanomaterials from the environment (indoor and outdoor);
- Genotoxic and/or epigenetic responses to nanoparticles and nanomaterials from applications in nanomedicine;
- Genotoxic and/or epigenetic responses of cells and organisms to plastic nanoparticles from the environment (air, water, and soil) and plastic nanoparticles/nanomaterials from industrial productions.
Dr. Anna Maria Giuseppina Poma
Guest Editor
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Keywords
- genotoxicity
- nanomaterials
- cellular and molecular stress biomarkers
- nanotoxicogenomics
- nanoplastics
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