Special Issue "Functionalized Magnetic Nanomaterials"
Deadline for manuscript submissions: 30 September 2021.
Interests: nanostructured composites; functionalized magnetic nanoparticles; magnetic micro/nanogels; self-assembled nanoparticles systems; smart composites based on magnetic nanoparticles and stimuli responsive polymers; surface physics and chemistry of nanoparticles; nanomaterials characterization by X-ray Photoelectron Spectroscopy
Interests: magnetic nanoparticles; magnetic fluids; ferrofluids; bioferrofluids; magnetic nanocomposites; magnetorheological fluids; magnetic properties; flow properties; structure analysis by scattering techniques; engineering and biomedical applications of magnetizable nanomaterials
Magnetic nanomaterials engineered with a large variety of functional coatings have gained much interest because of their possible applications with dual-mode manipulation controlled by a magnetic field and through the appropriate design of surface properties.
Among the magnetic nanomaterials, magnetic iron oxide nanoparticles and their nanocomposites are very promising for innovative applications in nanomedicine and biotechnology, such as nanotherapeutics, multimodal imaging, targeted drug delivery, hyperthermia, analyte monitoring, and enzyme, protein, and nucleic acid separations, due to their large surface area, excellent magnetic properties, and low toxicity. The nature of magnetic nanoparticles’ surface coating is essential for their behavior in biorelevant media. Well separated or in clusters, with proper surface functionalization, usually dispersed in liquid carriers (bioferrofluids) or embedded/encapsulated in polymeric networks, magnetic nanoparticles are the basic building blocks of a large variety of multifunctional vehicles.
The surface modification of magnetic nanomaterials, including the attachment of functional groups necessary for applications based on interactions ranging from nonspecific (e.g., ionic, hydrophobic/hydrophilic, and hydrogen bond) through group-specific to specific-affinity interactions, is an important issue for the future progress of medical and industrial applications.
The design and preparation of functionalized magnetic nanomaterials could have a strong applicative impact in many fields, such as diagnosis and treatment, regenerative medicine, tissue engineering, magnetic bioseparation, protein immobilization, biocatalysis, biosensors, or water purification, to mention only a few.
In this context, the aim of this Special Issue is to publish original research papers and comprehensive reviews dealing with the most important issues concerning the synthesis, advance properties investigations, and potential applications of functionalized magnetic nanomaterials.
Dr. Rodica Paula Turcu
Prof. Dr. Ladislau Vekas
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- magnetic nanomaterials
- surface functionalization
- functionalized magnetic nanoparticles
- physical–chemical characterization
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Effect of mitoxantrone-coupled SPIONs on pancreatic tumor spheroids
Authors: Ralf Friedrich
Affiliation: Uni-Klinikum Erlangen, Germany
Abstract: Pancreatic ductal adenocarcinoma is a hardly treatable, deadly malignancy. Recently, three-dimensional spheroid cell cultures of pancreatic ductal adenocarcinoma have improved the study of this cancer type. Here we describe the establishment of three-dimensional spheroid cell structures in different human pancreatic ductal adenocarcinoma cell lines and a potential new treatment approach using superparamagnetic iron oxide nanoparticles (SPION) as a drug delivery system for mitoxantrone (MTO). Following the generation of different tumor spheroids, free MTO and MTO-functionalized SPIONs were tested for cytotoxic efficacy. The tumor spheroids showed a dose-dependent toxic effect to the treatment with only slightly altered differences between free MTO and SPION-MTO, indicating the applicability of the functionalized SPIONs for magnetic drug targeting.