Antimicrobial Nanomaterials: Development and Applications

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 965

Special Issue Editors


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Guest Editor
Laboratory Smart Components and Systems for Sustainable Manufacturing, Department for Sustainability, Division Technologies and Materials for Sustainable Manufacturing Industry, ENEA Research Center, 80055 Portici, Italy
Interests: nanocomposites; hybrid materials; nanomaterials; composites; polymeric materials; polymer characterization; biomaterials; antimicrobial coating; additive manufacturing
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Industrial Engineering, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy
Interests: polymers; composites; nanomaterials; green materials; natural extracts; antibacterial nanoparticles; electrospinning; material characterization
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The growing threat of antimicrobial resistance and the need for advanced infection control have accelerated the development of antimicrobial nanomaterials. Over the past two decades, nanotechnology has enabled the creation of materials with enhanced biological activity and novel mechanisms of action distinct from traditional antibiotics. These include metallic, polymeric, and hybrid nanostructures, often endowed with multifunctional capabilities such as targeted delivery, biofilm disruption, and environmental responsiveness.

This Special Issue will present recent advances in the design, synthesis, characterization, and application of antimicrobial nanomaterials. It will highlight the interdisciplinary nature of this field, bridging materials science, microbiology, chemistry, biomedical engineering, and environmental science. Emphasis will be placed on tailoring nanomaterials for specific antimicrobial functions, integrating them into devices or coatings, and assessing their performance and safety in real-world contexts.

Key topics include smart nanomaterials, surface functionalization, nano–bio interactions, and scalable fabrication methods, with a focus on clinical and industrial relevance.

Contributions are invited in the form of original research, reviews, and short communications that address, but are not limited to, the following topics:

  • Design and synthesis of antimicrobial nanomaterials (metallic, polymeric, hybrid, etc.);
  • Mechanistic studies of antimicrobial action at the nanoscale;
  • Functionalization for targeted or responsive antimicrobial activity;
  • Biomedical applications (e.g., wound healing, implants, drug delivery);
  • Environmental and industrial uses (e.g., water treatment, packaging);
  • Integration into devices, coatings, or composite systems.

Submissions should present novel insights, methodologies, and clear relevance to the development and application of antimicrobial nanomaterials.

Dr. Loredana Tammaro
Dr. Gianluca Viscusi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial nanomaterials
  • functional nanomaterials
  • bioactive surfaces
  • nanostructured coatings
  • nanoparticle synthesis
  • mechanisms of antimicrobial action
  • hybrid nanomaterials
  • environmental remediation

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Published Papers (1 paper)

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Review

24 pages, 1789 KB  
Review
Biofilm Control with Rare-Earth Oxides: A Mechanistic Framework for Next-Generation Antibiofilm Materials
by John H. T. Luong
Nanomaterials 2026, 16(5), 302; https://doi.org/10.3390/nano16050302 - 27 Feb 2026
Viewed by 731
Abstract
Biofilm-associated infections remain a major barrier to wound healing, implant integration, and chronic infection management. Rare-earth oxides (REOs) have emerged as promising antibiofilm materials, though their mechanisms, limitations, and translational potential are still being defined. Cerium oxide (CeO2) serves as the [...] Read more.
Biofilm-associated infections remain a major barrier to wound healing, implant integration, and chronic infection management. Rare-earth oxides (REOs) have emerged as promising antibiofilm materials, though their mechanisms, limitations, and translational potential are still being defined. Cerium oxide (CeO2) serves as the benchmark due to its redox adaptability, oxygen-vacancy-driven catalytic activity, and host compatibility. In contrast, non-ceria REOs show antibiofilm effects under more restricted conditions, often requiring surface functionalization, composite architectures, or hybrid organic–inorganic interfaces—such as polyphenol coatings or hydroxyapatite-based composites—to achieve comparable activity. Across systems, biofilm control arises not from bactericidal potency but from matrix-level mechanisms including extracellular polymeric substance (EPS) destabilization, extracellular DNA (eDNA) sequestration, redox modulation, and quorum-sensing interference. Preclinical and near-clinical evidence, particularly in chronic wound models, supports the translational relevance of these mechanisms, though the evidence base remains preliminary. This review synthesizes mechanistic data across cerium-, samarium-, lanthanum-, and strontium-based systems to establish a unified framework for REO-mediated biofilm disruption. REOs are positioned as biofilm-modulating platforms that complement antibiotics, enhance healing, and improve outcomes. Design rules emphasize controlled redox activity, targeted coordination chemistry, functional surface engineering, and host-compatible performance, alongside regulatory and manufacturing guidance for future development. Full article
(This article belongs to the Special Issue Antimicrobial Nanomaterials: Development and Applications)
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