Nanotoxicology: Small Particles, Big Concerns
A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".
Deadline for manuscript submissions: 25 July 2026 | Viewed by 767
Editor
2. Faculté de Pharmacie, Université de Strasbourg, 74 Route du Rhin, 67400 Illkirch-Graffenstaden, France
Interests: mechanistic nanotoxicology; toxicological assessment of nanomaterials; advanced 3D in vitro models; lung organoids; 3D bioprinting of pulmonary tissu models
Special Issue Information
Dear Colleagues,
The rapid development and widespread integration of engineered nanomaterials into industrial, medical, environmental, and consumer applications have raised increasing concerns regarding their potential impacts on human health and ecosystems. Since the early 2000s, nanotoxicology has emerged as a dedicated interdisciplinary field aimed at understanding how the unique physicochemical properties of nanoparticles, such as size, shape, surface chemistry, solubility, and reactivity, govern their biological interactions and toxicological profiles. While substantial progress has been made, the continuous diversification of nanomaterials and exposure scenarios poses persistent scientific and regulatory challenges.
This Special Issue, “Nanotoxicology: Small Particles, Big Concerns”, will provide a focused and forward-looking overview of current advances in nanotoxicology, with particular emphasis on mechanistic understanding, biologically relevant exposure conditions, and the integration of novel methodologies into safety assessment strategies. This Special Issue will bridge fundamental research and applied perspectives, addressing both human and environmental health dimensions.
We welcome contributions highlighting cutting-edge research on nanoparticle–biological interactions and toxicity mechanisms, including cellular uptake pathways, intracellular trafficking, biotransformation, biomolecular and protein corona, oxidative stress, inflammation, genotoxicity, immunomodulation, adverse outcome pathways (AOPs), and long-term or low-dose effects. Studies employing New Approach Methods (NAMs), such as advanced in vitro models (3D cultures, organ-on-chip systems), high-content imaging, omics-based approaches, and computational or in silico toxicology, are strongly encouraged, especially when linked to mechanistic insights and regulatory relevance.
This Special Issue solicits original research articles, short communications, and comprehensive review papers addressing experimental, methodological, and conceptual advances in nanotoxicology. Interdisciplinary studies bridging materials science, toxicology, biology, and environmental sciences are encouraged to support the responsible and sustainable development of nanotechnologies.
Dr. Carole Ronzani
Guest Editor
Manuscript Submission Information
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Keywords
- nanotoxicology
- mechanisms of toxicity
- new approach methods (NAMs)
- engineered nanomaterials
- in vitro and in vivo models
- risk assessment
- regulatory science
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