Nanotechnology-Based Electrochemical Biosensors

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Nanoelectronics, Nanosensors and Devices".

Deadline for manuscript submissions: 25 September 2026 | Viewed by 1332

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Guest Editor
Department of Experimental Medicine Sapienza, University of Rome, Rome, Italy
Interests: (bio)sensors; nanomaterials; electrode modifications; electrochemical techniques
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Special Issue Information

Dear Colleagues,

In the diagnostic field, nanotechnology-based electrochemical biosensors are used to detect biomarkers related to several diseases. However, the majority of biomarker diagnostic testing is not performed at the point-of-care (POC); rather, it is conducted in centrally located facilities that are far away from the patient care site because these facilities have the required tools and personnel. This results in an increase in waiting times and testing costs.

Because biosensor-based nanotechnology can be affordable, reliable, and readily available at the point of treatment, it will aid in the solution of these issues. Using innovative nanomaterials as transducers is one way to enhance biosensor performance. Among the various types of biosensors, nanomaterial-based electrochemical biosensors have shown great promise.

Nanomaterial-based biosensors have strength, repeatability, and sensitivity, which, when combined with their small size, large surface area, and interfaces, have proved to be quite advantageous. Moreover, they offer new immobilization structures with improved aspects, significant electrical conductivity, and a greater number of biomolecules per area/volume. Thus, nanomaterials will play a crucial role in the fabrication of an ideal point of care application of electrochemical biosensors.

The aim of this Special Issue is to collect novel electrochemical biosensors based on nanotechnologies for biomarker monitoring in different research fields. Topics of interest include, but are not limited to, the following:

  • Nanomaterials;
  • Biosensors;
  • Electrochemical techniques;
  • Point-of-care;
  • Smart devices.

We invite authors to submit manuscripts for this Special Issue on “Nanotechnology-Based Electrochemical Biosensors”. Original research papers and critical reviews are welcome.

Dr. Cristina Tortolini
Guest Editor

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Keywords

  • nanomaterials
  • biosensors
  • electrochemical techniques
  • point-of-care
  • smart devices

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Published Papers (1 paper)

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Research

16 pages, 3681 KB  
Article
Self-Templated Highly Porous Gold Electrodes for Antibiofouling Electrochemical (Bio)Sensors
by Anisa Degjoni, Cristina Tortolini, Daniele Passeri, Andrea Lenzi and Riccarda Antiochia
Nanomaterials 2026, 16(2), 87; https://doi.org/10.3390/nano16020087 - 8 Jan 2026
Cited by 1 | Viewed by 800
Abstract
Biofouling arises from non-specific adsorption of several components present in complex biofluids, such as full blood, on the surface of electrochemical biosensors, with a resulting loss of functionality. Most biomarkers of clinical relevance are present in biological fluids at extremely low concentrations, making [...] Read more.
Biofouling arises from non-specific adsorption of several components present in complex biofluids, such as full blood, on the surface of electrochemical biosensors, with a resulting loss of functionality. Most biomarkers of clinical relevance are present in biological fluids at extremely low concentrations, making antibiofouling strategies necessary in electrochemical biosensing. Here, we demonstrate the effect of a highly porous gold (h-PG) film electrodeposited on a gold screen-printed electrode (AuSPE) using a self-templated method via hydrogen bubbling as an antibiofouling strategy in electrochemical biosensor development following exposure of the electrode to bovine serum albumin (BSA) at two different concentrations (2 and 32 mg/mL). The h-PG film has a high electrochemically active surface area, 88 times higher than the AuSPE electrode, with a pore size ranging from 2 to 50 μm. A rapid decrease in the Faradaic current was observed with the unmodified AuSPE, attesting to the strong biofouling effect of BSA at both concentrations tested. Notably, the h-PG-modified electrode showed an initial peak current decline, more evident at a higher BSA concentration, followed by rapid electrode regeneration when the electrode was left idle in the biofouling solution. Similar results were obtained for unmodified and modified electrodes in real serum and plasma samples. The regeneration process, explained in terms of balance between h-PG pore size and protein size, the nanoscale architecture of the h-PG electrodes, and repulsive electrostatic forces, indicates the huge potential of the h-PG film for use in biomedical electrochemical sensing. Full article
(This article belongs to the Special Issue Nanotechnology-Based Electrochemical Biosensors)
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