Special Issue "Surface Modification and Functionalization of Nanoparticles"

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: 20 December 2020.

Special Issue Editor

Prof. Dr. Jose L. Arias
Guest Editor
Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Campus Universitario de Cartuja s/n, 18071 Granada, Spain
Interests: active drug targeting; biomedical applications of colloids and nanoparticles; biopharmacy; drug absorption; drug delivery; drug release; formulation and evaluation of pharmaceutical dosage forms; hyperthermia-based anticancer treatment; in vivo fate of nanoplatforms; ligand–receptor interactions and nanoparticle endocytosis; long-circulating nanoparticles; magnetic colloids; nanoteranosis; passive drug targeting; PEGylated nanoparticles; pharmaceutical technology; pharmacokinetics; stimuli sensitive nanostructures; surface chemistry and interface science; surface functionalization of nanoparticles

Special Issue Information

Dear Colleagues,

Tailoring surface chemistry has contributed to the perfect control of the biological fate of nanomedicines, while assuring their colloidal stability in vitro and in vivo. To that aim, the nanoparticle surface is chemically modified using appropriate polymeric stabilizers/surfactants, by generating polymeric shells, and/or by the formation of lipid-like coatings. As a consequence, a specific in vivo targeting is possible thanks to the enhanced permeability and retention (EPR) effect. Additionally, the delivery of therapeutic molecules (and imaging agents) to the targeted tissue/cell can be maximized if this passive targeting strategy is combined with the surface decoration of the nanomedicine (or theranostic particle) with biomolecules determining specific recognition mechanisms, i.e., ligand-mediated drug targeting.

Surface functionalization of nanoplatforms has also been advantageously used in cell labeling and imaging, tissue engineering, cell separation and cell sensing, separation of biochemicals, enzyme/protein immobilization, bioanalysis, and immunoassays, just to mention some additional applications in Biomedicine. Interestingly, surface decorated nanoparticles have also found uses far from Biomedicine, e.g., catalysis, energy-based research, and environmental applications.

This Special Issue of Nanomaterials aims at receiving contributions (in the form of research articles, letters, reviews, and communications) to update the basis, applications, and perspectives in the surface engineering of nanoparticles, including the most promising moves towards advanced chemical surface modifications. I kindly invite you to submit a contribution to this Special Issue of Nanomaterials “Surface Modification and Functionalization of Nanoparticles”.

Prof. Dr. Jose L. Arias
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Biomedical applications
  • Enhanced permeation and retention effect
  • Environmental applications
  • Ligand-mediated delivery of drugs, genes, and imaging agents
  • Nanoparticle
  • Passive drug targeting
  • Theranosis

Published Papers

This special issue is now open for submission.
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