New Insights into the Therapeutic Efficacy of Nanomaterials

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (15 September 2024) | Viewed by 1610

Special Issue Editor


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Guest Editor
Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Campus Universitario de Cartuja s/n, 18071 Granada, Spain
Interests: active drug targeting; biomedical applications of colloids and nanoparticles; biopharmacy; drug absorption; drug delivery; drug release; formulation and evaluation of pharmaceutical dosage forms; hyperthermia-based anticancer treatment; in vivo fate of nanoplatforms; ligand-receptor interactions and nanoparticle endocytosis; long-circulating nanoparticles; magnetic colloids; nanoteranosis; passive drug targeting; PEGylated nanoparticles; pharmaceutical technology; pharmacokinetics; stimuli sensitive nanostructures; surface chemistry and interface science; surface functionalization of nanoparticles
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Special Issue Information

Dear Colleagues,

Targeted therapies, based on multifunctional nanoparticles, have generated promising results in terms of optimized efficacy and reduced collateral toxicity. However, engineering nanoparticulate systems continues to encounter technical problems in vitro, e.g. reproducibility, the appropriate loading of active agents, or colloidal stability, to name only a few. Furthermore, biological barriers repersent important walls interfering with their successful in vivo fate. The blood–brain barrier, pleural fluid, and mucins on mucous membranes are among the most relevant barricades limiting the targeted delivery of nanomedicines. Recently, there has been significant progress in the optimization of the therapeutic efficacy of these nanomaterials.

This Special Issue of Nanomaterials hopes to receive contributions (in the form of research articles, letters, reviews and communications) that provide an update on the applications and perspectives associated with the engineering of therapeutically efficient nanomedicines. In addition, this Special Issue will analyze the barriers to drug delivery and provides an overview of the various approaches employed to address related topics.

I kindly invite you to contribute to this Special Issue of Nanomaterials entitled “New Insights into Therapeutic Efficacy of Nanomaterials”.

Prof. Dr. Jose L. Arias
Guest Editor

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Keywords

  • ligand-mediated delivery
  • stimuli-sensitive nanomaterials
  • image-guided drug delivery
  • nanotheranosis
  • biological barriers
  • nanoparticles
  • stimuli-sensitive nanomaterials
  • passive drug targeting
  • active drug targeting

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Published Papers (1 paper)

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Research

25 pages, 10477 KiB  
Article
Portable Homemade Magnetic Hyperthermia Apparatus: Preliminary Results
by Teresa Castelo-Grande, Paulo A. Augusto, Lobinho Gomes, Eduardo Calvo and Domingos Barbosa
Nanomaterials 2024, 14(22), 1848; https://doi.org/10.3390/nano14221848 - 19 Nov 2024
Viewed by 1160
Abstract
This study aims to describe and evaluate the performance of a new device for magnetic hyperthermia that can produce an alternating magnetic field with adjustable frequency without the need to change capacitors from the resonant bank, as required by other commercial devices. This [...] Read more.
This study aims to describe and evaluate the performance of a new device for magnetic hyperthermia that can produce an alternating magnetic field with adjustable frequency without the need to change capacitors from the resonant bank, as required by other commercial devices. This innovation, among others, is based on using a capacitator bank that dynamically adjusts the frequency. To validate the novel system, a series of experiments were conducted using commercial magnetic nanoparticles (MNPs) demonstrating the device’s effectiveness and allowing us to identify new challenges associated with the design of more powerful devices. A computational model was also used to validate the device and to allow us to determine the best system configuration. The results obtained are consistent with those from other studies using the same MNPs but with magnetic hyperthermia commercial equipment, confirming the good performance of the developed device (e.g., consistent SAR values between 1.37 and 10.80 W/gMNP were obtained, and experiments reaching temperatures above 43 °C were also obtained). This equipment offers additional advantages, including being economical, user-friendly, and portable. Full article
(This article belongs to the Special Issue New Insights into the Therapeutic Efficacy of Nanomaterials)
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