Nanomechanics: From Theory to Application
Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 16368
2. Institut de Bioenginyeria de Catalunya (IBEC), The Barcelona Institute of Science and Technology, Barcelona, Spain
3. Department of Materials and Physical Chemistry, Faculty of Chemistry, Universitat de Barcelona (UB), Barcelona, Spain
Interests: nanomechanics; biophysics; lipid membranes; single molecules; force spectroscopy; atomic force microscopy
Interests: biophysics; membrane remodeling; lipid membranes; nanomechanics; membrane dynamics; atomic force microscopy; high-speed force spectroscopy; force spectroscopy
Nanomechanics is an area of nanoscience that studies fundamental mechanical properties of physical systems at the nanoscale. Nanomechanics has developed at the intersection of classical mechanics, statistical mechanics, and quantum chemistry, and the overlapping of solid-state physics, biophysics, and materials science.
In nature, all key steps involve mechanical movement at the molecular level, and, moreover, the macroscopic properties of polymeric materials are closely related to the molecular composition, structure, conformation, and interactions at this level.
Nanomechanical studies of single macromolecules contribute to the comprehension of fundamental aspects concerning their structural, mechanical, and binding properties. Understanding the elastic behavior, or deformation, of individual macromolecules is an essential issue in both biophysics and materials science. Viscoelastic relaxation provides polymers and thin films with time-dependent properties necessary for energy dissipation and frequency-dependent stiffening or reswelling, among others. The forces that hold molecules together in supramolecular structures are generally weak intermolecular forces or interactions. Such interactions play a relevant role in the physical properties and function of nanostructures and biological entities.
The development of experimental nanoscale and single-molecule manipulation methods has allowed for the tracking of individual species and the precise application and measurement of minute forces, opening new perspectives in life sciences as well as in materials science. This has particular importance in areas where temporal and spatial averaging is to be avoided, mechanical forces need to be measured, and individual species are to be tracked. Among them, the most common are the mechanical transducers, such as microneedles and atomic force microscopy-based force spectroscopy (AFM-FS), and the external field manipulators, such as hydrodynamic flow and magnetic or optical traps (magnetic or optical tweezers), which have permitted studies on the role of the mechanosensitive proteins and lipids in membranes, protein folding or DNA mechanics, the elasticity of macromolecules, the mechanical work generated by molecular motors, and cell and tissue mechanics.
This Special Issue of Nanomaterials, entitled “Nanomechanics: From Theory to Application”, will cover the aforementioned advances, comprising both theoretical and experimental findings in different areas from nanostructures and materials to biological entities.
Dr. Marina Inés Giannotti
Dr. Lorena Redondo-Morata
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- single molecules
- thin films
- force spectroscopy
- optical tweezers.