Next Article in Journal
Scaling Up the Production of Electrodeposited Nanowires: A Roadmap towards Applications
Previous Article in Journal
Bottom-Up Fabrication of DNA-Templated Electronic Nanomaterials and Their Characterization
Previous Article in Special Issue
Asymmetric Lipid Transfer between Zwitterionic Vesicles by Nanoviscosity Measurements
Review

Protein Hydrogels: The Swiss Army Knife for Enhanced Mechanical and Bioactive Properties of Biomaterials

Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain
*
Authors to whom correspondence should be addressed.
Academic Editors: Marina Inés Giannotti and Lorena Redondo-Morata
Nanomaterials 2021, 11(7), 1656; https://doi.org/10.3390/nano11071656
Received: 24 May 2021 / Revised: 17 June 2021 / Accepted: 18 June 2021 / Published: 24 June 2021
(This article belongs to the Special Issue Nanomechanics: From Theory to Application)
Biomaterials are dynamic tools with many applications: from the primitive use of bone and wood in the replacement of lost limbs and body parts, to the refined involvement of smart and responsive biomaterials in modern medicine and biomedical sciences. Hydrogels constitute a subtype of biomaterials built from water-swollen polymer networks. Their large water content and soft mechanical properties are highly similar to most biological tissues, making them ideal for tissue engineering and biomedical applications. The mechanical properties of hydrogels and their modulation have attracted a lot of attention from the field of mechanobiology. Protein-based hydrogels are becoming increasingly attractive due to their endless design options and array of functionalities, as well as their responsiveness to stimuli. Furthermore, just like the extracellular matrix, they are inherently viscoelastic in part due to mechanical unfolding/refolding transitions of folded protein domains. This review summarizes different natural and engineered protein hydrogels focusing on different strategies followed to modulate their mechanical properties. Applications of mechanically tunable protein-based hydrogels in drug delivery, tissue engineering and mechanobiology are discussed. View Full-Text
Keywords: hydrogel; protein; mechanical modulation; viscoelasticity; extracellular matrix; folding; single-molecule; nanomechanics hydrogel; protein; mechanical modulation; viscoelasticity; extracellular matrix; folding; single-molecule; nanomechanics
Show Figures

Figure 1

MDPI and ACS Style

Huerta-López, C.; Alegre-Cebollada, J. Protein Hydrogels: The Swiss Army Knife for Enhanced Mechanical and Bioactive Properties of Biomaterials. Nanomaterials 2021, 11, 1656. https://doi.org/10.3390/nano11071656

AMA Style

Huerta-López C, Alegre-Cebollada J. Protein Hydrogels: The Swiss Army Knife for Enhanced Mechanical and Bioactive Properties of Biomaterials. Nanomaterials. 2021; 11(7):1656. https://doi.org/10.3390/nano11071656

Chicago/Turabian Style

Huerta-López, Carla, and Jorge Alegre-Cebollada. 2021. "Protein Hydrogels: The Swiss Army Knife for Enhanced Mechanical and Bioactive Properties of Biomaterials" Nanomaterials 11, no. 7: 1656. https://doi.org/10.3390/nano11071656

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop