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Nanotechnology and 2D Materials for Regenerative Medicine

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (31 October 2025) | Viewed by 1958

Special Issue Editor


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Guest Editor
NEST Laboratory, Scuola Normale Superiore, Piazza San Silvestro 12, 56127 Pisa, Italy
Interests: graphene-based materials; CVD graphene; graphene-based neural interfaces; peripheral nerve regeneration; nerve conduits

Special Issue Information

Dear Colleagues,

Emerging nanotechnologies present many perspectives in the field of regenerative medicine by offering precise control over cellular environments and enhancing tissue repair processes.

The combination of different techniques and materials has been extensively studied regarding the development of innovative scaffolds with significantly enhanced cellular and tissue regenerative properties.

Nanomaterials enable the targeted delivery of drugs, growth factors, and genetic material, thus accelerating healing and reducing side effects. Graphene-based materials, black phosphorus, and transition metal dichalcogenides present a great opportunity to advance the field of tissue engineering; this is due to their exceptional chemical, topographical, and electrical properties. These nanomaterials can be engineered to closely mimic the extracellular matrix, providing an ideal environment for cell attachment, growth, and differentiation. In addition, 2D materials can be functionalized with bioactive molecules, enhancing their ability to guide tissue regeneration and repair.

As such, 2D nanomaterials have been widely utilized for the repair of skin, bone and cartilage tissues, such as in skeletal muscle repair, the regeneration of cardiac muscle, the treatment of brain disease and the regeneration of nerves. They have shown exceptional efficiency in tissue repair and excellent biocompatibility, highlighting their significant potential to be used in clinical applications.

This Special Issue welcomes the submission of original research-based articles and reviews that describe the fundamentals, progress, applications and challenges associated with the use of nanotechnology and 2D materials for regenerative medicine.

Dr. Domenica Convertino
Guest Editor

Manuscript Submission Information

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Keywords

  • regenerative medicine
  • nanotechnology
  • 2D nanomaterials
  • graphene
  • transition metal dichalcogenide
  • nanomedicine
  • nerve regeneration

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Published Papers (1 paper)

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Review

28 pages, 3387 KB  
Review
Silicon Carbide Neural Interfaces: A Review of Progress Toward Monolithic Devices
by Christopher L. Frewin, Matthew Melton, Evans Bernardin, Mohammad Beygi, Chenyin Feng and Stephen E. Saddow
Nanomaterials 2025, 15(24), 1880; https://doi.org/10.3390/nano15241880 - 15 Dec 2025
Viewed by 1481
Abstract
The promise of intracortical neural interfaces—to restore lost sensory and motor function and probe the brain’s activity—has long been constrained by device instability over chronic implantation. Conventional silicon-based probes, composed of heterogeneous materials, often fail due to mechanical mismatch, inflammatory responses, and interface-driven [...] Read more.
The promise of intracortical neural interfaces—to restore lost sensory and motor function and probe the brain’s activity—has long been constrained by device instability over chronic implantation. Conventional silicon-based probes, composed of heterogeneous materials, often fail due to mechanical mismatch, inflammatory responses, and interface-driven degradation, where stress can induce cracking, swelling, and exposure of cytotoxic elements to neural tissue. Silicon carbide (SiC) offers a compelling solution, combining chemical inertness, structural strength, and biocompatibility in both amorphous and crystalline forms. In this review, we discuss advances in SiC neural interfaces, highlighting contributions from multiple laboratories and emphasizing our own work on monolithic devices, constructed entirely from a single, homogeneous SiC material system. These devices mitigate interface-driven failures and show preliminary indications of magnetic resonance imaging (MRI) compatibility, with minimal image artifacts observed compared to conventional silicon probes, though further in vivo studies are needed to confirm thermal safety at high-field conditions. Collectively, SiC establishes a versatile platform for next-generation, durable neural interfaces capable of reliable, long-term brain interaction for both scientific and clinical applications. Full article
(This article belongs to the Special Issue Nanotechnology and 2D Materials for Regenerative Medicine)
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