Advances in Bioactive Materials for Nanomedicine

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: 25 February 2027 | Viewed by 1618

Editors


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Guest Editor
Department of Chemical Science and Technologies, University of Rome Tor Vergata, Via della Ricerca Scientifica 1, Rome, Italy
Interests: nanomaterials; anti-inflammatory nanoparticles; cancer therapy; cancer metabolism; regenerative medicine

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Guest Editor
Fondazione Policlinico Tor Vergata, U.O.S.D. Medical Oncology, Viale Oxford 81, Rome, Italy
Interests: cancer therapy; anti-inflammatory response; tumor resistance; nanoparticles

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Guest Editor
Dipartimento di Biologia, Via della Ricerca Scientifica, Roma, Italy
Interests: tuberculosis; infections in immunocompromised host; multidrug resistant infections; novel antimicrobial approaches

Special Issue Information

Dear Colleagues,

Nanotechnology is revolutionizing the medical field, such that the term “nanomedicine” has been coined to denote the application of nanomaterials to medicine. In fact, owing to their unique physicochemical properties at the nanoscale, nanomaterials have promptly offered significant advancements in diagnostic bioimaging, controlled drug delivery, and tissue engineering.

In recent years, scientific interest has focused on bioactive nanomaterials, which can modulate and/or elicit cellular behaviors and functions. For example, several nanoparticles of inorganic nature, such as metal and metal oxides, are gaining attention for their intrinsic anti-inflammatory, antioxidant, antimicrobial, and antitumor activities. Furthermore, polymeric and lipid nanoparticles, traditionally used as “inert” biocompatible nanocarriers, are now emerging as potent immunomodulatory agents, depending on their composition and design. Thus, bioactive nanomaterials promise significant improvements in the treatment of several pathological conditions.

This Special Issue, titled "Advances in Bioactive Materials for Nanomedicine", aims to share the latest progress in the synthesis, design, characterization, and medical applications of bioactive nanomaterials of organic, inorganic, and hybrid nature. We welcome original research articles, communications, and reviews. Research topics include, but are not limited to, the following: nanozymes, biomimetic nanomaterials for regenerative medicine, anti-inflammatory and antimicrobial nanoparticles, nanomaterials for anticancer therapy, immunotherapy, and vaccine delivery.

We look forward to receiving your contributions.

Dr. Francesca Corsi
Dr. Andrea Pelliccia
Prof. Dr. Maurizio Fraziano
Guest Editors

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Keywords

  • metal nanoparticles
  • nanozymes
  • biomimetic nanomaterials
  • surface functionalization
  • drug delivery
  • biofabrication
  • flow synthesis

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Published Papers (1 paper)

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Research

32 pages, 23060 KB  
Article
Characterising the Antimicrobial Performance of Engineered Layered Double Hydroxide Surfaces for Biofilm Control
by Federico Delle Fave, Michela Froio, Diego Cisternino, Suguna Jayaraman, Chris Ashley, Pier Gianni Medaglia and Francesco Giorgi
Nanomaterials 2026, 16(11), 666; https://doi.org/10.3390/nano16110666 - 25 May 2026
Viewed by 1118
Abstract
Antimicrobial resistance (AMR) is a growing global health concern driven by bacterial biofilm formation, which increases tolerance to treatments. Developing surface-based strategies to limit biofilm formation is therefore critical. Layered Double Hydroxides (LDHs) are 2D brucite-like nanomaterials with tuneable physicochemical properties that may [...] Read more.
Antimicrobial resistance (AMR) is a growing global health concern driven by bacterial biofilm formation, which increases tolerance to treatments. Developing surface-based strategies to limit biofilm formation is therefore critical. Layered Double Hydroxides (LDHs) are 2D brucite-like nanomaterials with tuneable physicochemical properties that may reduce bacterial colonisation. Their ease of synthesis, with scalability potential for industrial production, alongside their characteristic and tunable physicochemical properties, makes them a promising nanostructured coating for antimicrobial applications. This study evaluates LDH thin-film coatings as intrinsic antimicrobial surfaces, focusing on the combined effects of chemical composition, nanotopography, and wettability on biofilm formation in Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. Four aluminium-based LDHs (ZnAl-NO3, ZnAl-Cl2, MgAl-NO3, MgAl-Cl2) were synthesised via coprecipitation or in situ growth on aluminium substrates. Materials were characterised by XRD, SEM, EDS, and contact angle measurements. Antimicrobial performance was assessed by quantifying colony-forming units (CFU mL−1) after bacterial exposure. ZnAl-LDH surfaces showed significant antimicrobial activity against E. coli and S. aureus, while MgAl-LDHs showed no effect and occasionally increased bacterial growth. None of the LDH surfaces tested exhibited significant antimicrobial activity against P. aeruginosa strain. The antimicrobial performance of ZnAl-LDH can be attributed to the concurrent effect of the surface chemistry, wettability, and sharp platelet-like nanotopography. The results obtained demonstrate that ZnAl-LDH-based coatings are promising antimicrobial materials with potential relevance for translational research in clinical antimicrobial surface development. Full article
(This article belongs to the Special Issue Advances in Bioactive Materials for Nanomedicine)
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