Topical Collection "Green Chemistry"
A topical collection in Methods and Protocols (ISSN 2409-9279).
Prof. Dr. Artur M. S. Silva
Department of Chemistry & QOPNA—Organic Chemistry, Natural Products and Food Stuffs, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal
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Interests: organic synthesis; organocatalysis; transition-metal catalysis; oxygen and nitrogen heterocyclic compounds; chemistry of natural products; green chemistry; microwave-assisted organic synthesis; ohmic heating-assisted organic synthesis
Green Chemistry has attracted the interest of the scientific community, mainly due to its environmental effect. The development of efficient synthetic methodologies is no longer just related with good yields, but is more and more related with greener procedures. In this regard, the use of efficient catalysts and/or water as a medium has been implemented in recent years. Biotransformations, where enzymes are used, can be highlighted, but recent energy sources, such as ohmic heating, are also important examples. However, green methodologies are not just confined to these examples; their principles are vast and all important.
This Collection of Methods and Protocols aims to compile both original articles and reviews, covering the most recent advances on Green Chemistry.
As Guest Editors of this Collection of Methods and Protocols, we invite you to provide original research contributions, as well as review articles, related to the most recent developments and/or achievemets in green chemistry.
We look forward to receiving your contributions to this Collection.
Prof. Dr. Artur M. S. Silva
Dr. Diana C. G. A. Pinto
Manuscript Submission Information
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- Sustainable chemistry
- Microwave-assisted organic synthesis
- Ohmic heating-assisted organic synthesis
- Chemistry with economic and environmental benefits
- Solvent-free extractions
- Solvent-free chemical transformations
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Process intensification for bicyclic aziridine synthesis from N-alkylpyridinium salts using a continuous UV-light photoflow approach
Milene A. G. Fortunato, Filipa Siopa, Carlos A. M. Afonso
Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
The discovery of potent biological properties of aminocyclopentitols and the promise that such effects might be exploited as an advantage in medicine have encouraged their synthesis. An efficient approach is the photochemical transformation of pyridinium salts to bicyclic-aziridines followed by aziridine ring-opening to aminocyclopentene derivatives. The reported productivity for this photoreaction under batch conditions is low 0.003 - 1.33 gL-1h-1 and 0.01- 0.36 gL-1h-1, using water and methanol as nucleophile/solvent, respectively, which constrains the subsequent synthetic pathways.  To overcome this productivity problem, recently, we developed three home-made continuous-ﬂow reactors, a ﬂuorinated ethylene propylene tube (FEP) reactor (internal diameter of 0.4 cm) and two parallel quartz reactors containing two different internal diameters (0.4 and 0.2 cm). The photochemical transformation of 1-n-butyl and 1-allyl pyridinium bromide salts to the correspondent α-hydroxycyclopenteno-aziridines (6-azabicyclo[3.1.0]hex-3-en-2-ols) was studied under continuous-flow conditions. The FEP reactor allowed the production of larger quantities of bicyclic aziridines (3.2 g), however the best productivity result was obtained for the parallel quartz reactor with 0.4 internal diameter (3.7 gL−1h−1 and 1.4 gL−1h−1), revealing a huge improvement compared with the reported literature under batch conditions (8 and 28 times better, respectively). Due to this result, hereby we present the development and comparison of a new home-made parallel quartz continuous-ﬂow reactor with larger length and internal diameter. To set-up the new reactor we first evaluated the productivity of the photoreaction (Scheme 1) under batch conditions using three quartz tubes with the same length and diameter of the ones used in the continuous-ﬂow reactor.