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Open AccessProtocol

Solvent-Free Synthesis of 2,5-Bis((dimethylamino)methylene)cyclopentanone

Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal
Author to whom correspondence should be addressed.
Methods Protoc. 2019, 2(3), 69;
Received: 29 June 2019 / Revised: 2 August 2019 / Accepted: 7 August 2019 / Published: 12 August 2019
(This article belongs to the Collection Green Chemistry)
Available protocols for the synthesis of ketocyanine dyes precursor 2,5-bis((dimethylamino)methylene)cyclopentanone are not straightforward and the reported yields are low to moderate. The important feature in the synthesis of this product through organocatalyzed condensation of cyclopentanone and N,N-Dimethylformamide dimethyl acetal is the removal of methanol produced during the reaction. By studying the reaction profile, in particular the selectivity for the formation of mono- and bis-condensation products, a high yield of the desired product can be obtained through an operationally simple and solvent-free protocol. View Full-Text
Keywords: dyes; organocatalysis; green chemistry dyes; organocatalysis; green chemistry
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S. Martins, I.; A. S. Coelho, J. Solvent-Free Synthesis of 2,5-Bis((dimethylamino)methylene)cyclopentanone. Methods Protoc. 2019, 2, 69.

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Methods Protoc., EISSN 2409-9279, Published by MDPI AG
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