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Special Issue "Natural and Synthetic Molecules for Tissue Protection"

A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: 30 September 2020.

Special Issue Editor

Dr. Seyed Khosrow Tayebati
Guest Editor
Università degli Studi di Camerino, Camerino, Italy
Interests: neurodegenerative disorders; hypertension; metabolic syndrome; brain protection; phospholipids; antioxidants

Special Issue Information

Dear Colleagues,

Tissue protection represents a challenge both in health and in disease. In Western countries, China, Russia, and other emerging countries (e.g., India), new lifestyles, the use of high technological facilities, environmental pollution, electromagnetic waves, and radioactivity lead to a great range of tissue and organ damage. The populations living in these contexts are aware of this high risk for their health and try to face it with appropriate lifestyle and protective molecules.

These protective substances include different families of products trying through a variety of approaches to restore the pre-insult state of tissues. These molecules include antioxidants, immune-reinforcing agents, vitamins, and many other products with a tissue-specific protective activity (e.g., neuronal, endothelial, and cardiovascular).

Natural compounds, their derivatives, and purely synthetic ones belong to a variegated class of tissue protectants. The appropriate choice of these molecules is crucial in tissue and organ preservation. For this reason, several preclinical and clinical studies are available in the literature, which evaluate both protective mechanisms and protectant molecules. Deep comprehension of the insult that causes tissue damage could be essential to choosing the suitable disease-modifying compound for recovering health status.

The analysis of different tissue-protective strategies, based on the knowledge of the damage mechanisms, has led to the development of several protective compounds. Nervous tissue is among the most sensitive because any kind of insult is irreversible. Therefore, its protection is crucial to ensure correct function. Many laboratories worldwide are working on new agents to reduce the damage to the nervous system, protecting neuronal microenvironment. Other molecules have been used to protect the renal, cardiovascular, and gastro-enteric system.

This Special Issue will publish research articles or reviews covering all kinds of natural and synthetic compounds with protective activity in different tissues. Manuscripts that highlight different molecules with a possible preventive activity against damage in healthy tissue are also welcome.

Dr. Seyed Khosrow Tayebati
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • inflammation
  • tissue protection
  • natural and synthetic protectants
  • antioxidants
  • phospholipids
  • anti-inflammatory compounds

Published Papers (1 paper)

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Open AccessReview
The Role of Hormones and Trophic Factors as Components of Preservation Solutions in Protection of Renal Function before Transplantation: A Review of the Literature
Molecules 2020, 25(9), 2185; - 07 May 2020
Transplantation is currently a routine method for treating end-stage organ failure. In recent years, there has been some progress in the development of an optimal composition of organ preservation solutions, improving the vital functions of the organ and allowing to extend its storage [...] Read more.
Transplantation is currently a routine method for treating end-stage organ failure. In recent years, there has been some progress in the development of an optimal composition of organ preservation solutions, improving the vital functions of the organ and allowing to extend its storage period until implantation into the recipient. Optimizations are mostly based on commercial solutions, routinely used to store grafts intended for transplantation. The paper reviews hormones with a potential nephroprotective effect, which were used to modify the composition of renal perfusion and preservation solutions. Their effectiveness as ingredients of preservation solutions was analysed based on a literature review. Hormones and trophic factors are innovative preservation solution supplements. They have a pleiotropic effect and affect normal renal function. The expression of receptors for melatonin, prolactin, thyrotropin, corticotropin, prostaglandin E1 and trophic factors was confirmed in the kidneys, which suggests that they are a promising therapeutic target for renal IR (ischemia-reperfusion) injury. They can have anti-inflammatory, antioxidant and anti-apoptotic effects, limiting IR injury. Full article
(This article belongs to the Special Issue Natural and Synthetic Molecules for Tissue Protection)
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