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Article

Tart Cherry Juice and Seeds Affect Pro-Inflammatory Markers in Visceral Adipose Tissue of High-Fat Diet Obese Rats

1
School of Pharmacy, University of Camerino, 62032 Camerino, Italy
2
Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, 04103 Leipzig, Germany
3
Institute of Metabolic and Cardiovascular Diseases (I2MC), Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Toulouse, 31432 Toulouse, France
4
School of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Karel Šmejkal, Leonidas A. Phylactou and Jianbo Xiaoc
Molecules 2021, 26(5), 1403; https://doi.org/10.3390/molecules26051403
Received: 4 December 2020 / Revised: 3 February 2021 / Accepted: 25 February 2021 / Published: 5 March 2021
(This article belongs to the Special Issue Natural and Synthetic Molecules for Tissue Protection)
Background: Tart cherries (Prunus cerasus L.) are a rich source of anthocyanins. They are phytochemical flavonoids found in red and blue fruits, and vegetables that can reduce hyperlipidemia. Visceral Adipose Tissue (VAT) has emerged as a major player in driving obesity-related inflammatory response. Methods: This study has investigated the potential positive effects of tart cherries on rats with Diet-Induced Obesity (DIO). In particular, the inflammatory status in retroperitoneal (RPW) and perigonadal (PGW) adipose tissue were studied. Rats were fed ad libitum for 17 weeks with a hypercaloric diet with the supplementation of tart cherries seeds powder (DS) and seeds powder plus tart cherries juice containing 1mg of anthocyanins (DJS). In RPW and PGW, expression of CRP, IL-1 β, TNF-α, CCL2 and CD36, were measured by qRT-PCR, Western blot and immunohistochemistry techniques. Results: No differences in the weight of RPW and PGW animals were found between DS and DJS groups compared to DIO rats. However, an increase of inflammatory markers was observed in DIO group in comparison with control lean rats. A modulation of these markers was evident upon tart cherry supplementation. Conclusion: Study results suggest that tart cherry enriched-diet did not modify the accumulation of visceral fat, but it decreased inflammatory markers in both tissues. Therefore, this supplementation could be useful, in combination with healthy lifestyles, to modify adipose tissue cell metabolism limiting-obesity related organ damage. View Full-Text
Keywords: obesity; visceral adipose tissue; inflammation; tart cherries obesity; visceral adipose tissue; inflammation; tart cherries
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MDPI and ACS Style

Moruzzi, M.; Klöting, N.; Blüher, M.; Martinelli, I.; Tayebati, S.K.; Gabrielli, M.G.; Roy, P.; Micioni Di Bonaventura, M.V.; Cifani, C.; Lupidi, G.; Amenta, F.; Tomassoni, D. Tart Cherry Juice and Seeds Affect Pro-Inflammatory Markers in Visceral Adipose Tissue of High-Fat Diet Obese Rats. Molecules 2021, 26, 1403. https://doi.org/10.3390/molecules26051403

AMA Style

Moruzzi M, Klöting N, Blüher M, Martinelli I, Tayebati SK, Gabrielli MG, Roy P, Micioni Di Bonaventura MV, Cifani C, Lupidi G, Amenta F, Tomassoni D. Tart Cherry Juice and Seeds Affect Pro-Inflammatory Markers in Visceral Adipose Tissue of High-Fat Diet Obese Rats. Molecules. 2021; 26(5):1403. https://doi.org/10.3390/molecules26051403

Chicago/Turabian Style

Moruzzi, Michele, Nora Klöting, Matthias Blüher, Ilenia Martinelli, Seyed Khosrow Tayebati, Maria Gabriella Gabrielli, Proshanta Roy, Maria Vittoria Micioni Di Bonaventura, Carlo Cifani, Giulio Lupidi, Francesco Amenta, and Daniele Tomassoni. 2021. "Tart Cherry Juice and Seeds Affect Pro-Inflammatory Markers in Visceral Adipose Tissue of High-Fat Diet Obese Rats" Molecules 26, no. 5: 1403. https://doi.org/10.3390/molecules26051403

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