molecules-logo

Journal Browser

Journal Browser

Advances in Surface Nano-Engineering of Nanomedicines: Physiochemical Characterization and In Vitro/In Vivo Evaluations

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Physical Chemistry".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 1537

Special Issue Editor


E-Mail Website
Guest Editor
Department of Pharmacy, American University of Madaba, Amman, Jordan
Interests: biopharmaceutics; polymeric nanoparticles; metal nanoparticles; liposomes; surface engineering of nanostructures; development and characterisation of nanomedicine; complement activation; controlled release solid dosage forms; transdermal drug delivery systems

Special Issue Information

Dear Colleagues,

The physico-chemical properties of nanoparticles, including their shape, size, charge, core structure, surface chemistry, and ligand properties play an important role as they may ultimately affect the in vitro and in vivo behavior of nanoparticles. In this respect, nanomedicines with desired physico-chemical properties are of great interest for successfully delivering many therapeutic agents to their target organs. There is also a growing interest in the physico-chemical modifications of nanomedicines’ surfaces (including soft and hard nanoparticles based on metals, inorganic compounds, lipids, and polymers) in the design of nanomedicines for active targeting. Surface engineering through conjugation of ligands to nanoparticles’ surfaces is also another emerging topic to be discussed. 

We are launching the Special Issue “Advances in Surface Nano-Engineering of Nanomedicines: Physicochemical Characterization and in Vitro / In Vivo Evaluations” in order to highlight recent advances in the field and share the latest experimental findings related to the formation, characterization, and in vitro/in vivo evaluations of nanoparticles—including hard nanoparticles, solid lipid nanoparticles, and liposomes and other related lipid–nano-self-assemblies—as well as their surface nanoengineering for active drug targeting applications. Contributions emphasizing upcoming opportunities in this research area and discussing factors affecting the successful development of surface engineered nanoparticles for active drug targeting are also welcomed. Considering the multidisciplinary nature of the research area, this issue will collect original research and review articles from interested researchers with different backgrounds including drug delivery, biophysics, physical chemistry, and nanotechnology. 

Dr. Islam Hamad
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

nanotechnology in drug delivery
surface modification
nanomedicine characterization
physicochemical properties of nanomedicine
in vitro-in vivo correlation of nanomedicine

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

21 pages, 4608 KiB  
Article
Mitochondria-Targeted Lipid Nanoparticles Loaded with Rotenone as a New Approach for the Treatment of Oncological Diseases
by Leysan Vasileva, Gulnara Gaynanova, Darya Kuznetsova, Farida Valeeva, Anna Lyubina, Syumbelya Amerhanova, Alexandra Voloshina, Guzel Sibgatullina, Dmitry Samigullin, Konstantin Petrov and Lucia Zakharova
Molecules 2023, 28(20), 7229; https://doi.org/10.3390/molecules28207229 - 23 Oct 2023
Viewed by 1156
Abstract
This research is based on the concept that mitochondria are a promising target for anticancer therapy, including thatassociated with the use of oxidative phosphorylation blockers (mitochondrial poisons). Liposomes based on L-α-phosphatidylcholine (PC) and cholesterol (Chol) modified with cationic surfactants with triphenylphosphonium (TPPB-n, where [...] Read more.
This research is based on the concept that mitochondria are a promising target for anticancer therapy, including thatassociated with the use of oxidative phosphorylation blockers (mitochondrial poisons). Liposomes based on L-α-phosphatidylcholine (PC) and cholesterol (Chol) modified with cationic surfactants with triphenylphosphonium (TPPB-n, where n = 10, 12, 14, and 16) and imidazolium (IA-n(OH), where n = 10, 12, 14, and 16) head groups were obtained. The physicochemical characteristics of liposomes at different surfactant/lipid molar ratios were determined by dynamic/electrophoretic light scattering, transmission electron microscopy, and spectrophotometry. The hydrodynamic diameter of all the systems was within 120 nm with a polydispersity index of no more than 0.24 even after 2 months of storage. It was shown that cationization of liposomes leads to an increase in the internalization of nanocontainers in pancreatic carcinoma (PANC-1) and duodenal adenocarcinoma (HuTu 80) cells compared with unmodified liposomes. Also, using confocal microscopy, it was shown that liposomes modified with TPPB-14 and IA-14(OH) statistically better colocalize with the mitochondria of tumor cells compared with unmodified ones. At the next stage, the mitochondrial poison rotenone (ROT) was loaded into cationic liposomes. It was shown that the optimal loading concentration of ROT is 0.1 mg/mL. The Korsmeyer–Peppas and Higuchi kinetic models were used to describe the release mechanism of ROT from liposomes in vitro. A significant reduction in the IC50 value for the modified liposomes compared with free ROT was shown and, importantly, a higher degree of selectivity for the HuTu 80 cell line compared with the normal cells (SI value is 307 and 113 for PC/Chol/TPPB-14/ROT and PC/Chol/IA-14(OH)/ROT, respectively) occurred. It was shown that the treatment of HuTu 80 cells with ROT-loaded cationic liposomal formulations leads to a dose-dependent decrease in the mitochondrial membrane potential. Full article
Show Figures

Graphical abstract

Back to TopTop