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Special Issue "Ring-Closing Metathesis"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: closed (31 May 2010).

Special Issue Editor

Prof. Dr. Javier Pérez-Castells
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Guest Editor
Chemistry Department, Faculty of Pharmacy, Universidad San Pablo, CEU, 28,668 Madrid, Spain
Interests: organometallic chemistry; pharmaceutical chemistry; asymetric organic synthesis

Special Issue Information

Dear Colleagues,

The synthetic applications based on metathesis processes have recieved a huge attention over the past years. It has been an exciting adventure that will continue in the future based on the improvement in catalyst activity, tolerance and selectivity. New commercial and academic applications can be envisioned and the number of total synthesis of natural products based on these methodologies increases more and more. Ring closing metathesis (RCM) is an atom-economical reaction, compatible with many functional groups and allows the constuction of rings of practically any size including macrocycles. This special issue of Molecules will include new exciting contributions in RCM chemistry.

Prof. Dr. Javier Pérez-Castells
Guest Editor

Keywords

  • ring-closing alkene metathesis
  • ring-closing alkyne metathesis
  • enyne metathesis
  • carbenes
  • catalysis
  • molybdenum
  • ruthenium
  • synthetic methods
  • cycloisomerization

Published Papers (4 papers)

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Research

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Open AccessArticle
Organic-Inorganic Hybrid Silica Material Derived from a Monosilylated Grubbs-Hoveyda Ruthenium Carbene as a Recyclable Metathesis Catalyst
Molecules 2010, 15(8), 5756-5767; https://doi.org/10.3390/molecules15085756 - 23 Aug 2010
Cited by 12 | Viewed by 8190
Abstract
The synthesis of a monosilylated Grubbs-Hoveyda ruthenium alkylidene complex is described, as well as the preparation and characterization of the corresponding material by sol-gel cogelification with tetraethoxysilane (TEOS) and the assay of this recyclable supported catalyst in ring-closing diene and enyne metathesis reactions [...] Read more.
The synthesis of a monosilylated Grubbs-Hoveyda ruthenium alkylidene complex is described, as well as the preparation and characterization of the corresponding material by sol-gel cogelification with tetraethoxysilane (TEOS) and the assay of this recyclable supported catalyst in ring-closing diene and enyne metathesis reactions under thermal and microwave conditions. Full article
(This article belongs to the Special Issue Ring-Closing Metathesis)
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Open AccessArticle
Platinum-Catalyzed Hydrative Cyclization of 1,6-Diynes for the Synthesis of 3,5-Substituted Conjugated Cyclohexenones
Molecules 2010, 15(7), 5045-5052; https://doi.org/10.3390/molecules15075045 - 23 Jul 2010
Cited by 2 | Viewed by 5342
Abstract
We have developed a Pt(COD)Cl2-catalyzed hydrative cyclization of 1,6-diynes leading to the formation of functionalized cyclohexenones in good yields. Full article
(This article belongs to the Special Issue Ring-Closing Metathesis)
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Review

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Open AccessReview
Structural and Pharmacological Effects of Ring-Closing Metathesis in Peptides
Molecules 2010, 15(9), 6638-6677; https://doi.org/10.3390/molecules15096638 - 21 Sep 2010
Cited by 32 | Viewed by 7184
Abstract
Applications of ring-closing alkene metathesis (RCM) in acyclic α- and β-peptides and closely related systems are reviewed, with a special emphasis on the structural and pharmacological effects of cyclization by RCM. Full article
(This article belongs to the Special Issue Ring-Closing Metathesis)
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Open AccessReview
Construction of Eight-Membered Carbocycles with Trisubstituted Double Bonds Using the Ring Closing Metathesis Reaction
Molecules 2010, 15(6), 4242-4260; https://doi.org/10.3390/molecules15064242 - 11 Jun 2010
Cited by 44 | Viewed by 7084
Abstract
Medium sized carbocycles are particularly difficult to synthesize. Ring closing metathesis reactions (RCM) have recently been applied to construct eight-membered carbocycles, but trisubstituted double bonds in the eight-membered rings are more difficult to produce using RCM reactions. In this review, model examples and [...] Read more.
Medium sized carbocycles are particularly difficult to synthesize. Ring closing metathesis reactions (RCM) have recently been applied to construct eight-membered carbocycles, but trisubstituted double bonds in the eight-membered rings are more difficult to produce using RCM reactions. In this review, model examples and our own results are cited and the importance of the preparation of suitably designed precursors is discussed. Examples of RCM reactions used in the total synthesis of natural products are also outlined. Full article
(This article belongs to the Special Issue Ring-Closing Metathesis)
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