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Special Issue "Protein-Lipid Interactions and Membrane Organization"

A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: 30 November 2022.

Special Issue Editors

Dr. Fábio Fernandes
E-Mail Website
Guest Editor
Department of Bioengineering, Instituto Superior Técnico, University of Lisbon, 1049-001 Lisbon, Portugal
Interests: cellular biophysics; membrane biophysics; fluorescence; fluorescence microscopy; protein-lipid interaction; Förster resonance energy transfer; membrane domains; extracellular vesicles
Dr. Maria J. Sarmento
E-Mail Website
Guest Editor
Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, 1649-028 Lisbon, Portugal
Interests: fluorescence microscopy; membrane biophysics; lipid biology; super-resolution imaging; protein-lipid interaction; healthy ageing; cell nucleus; nucleus biomechanics

Special Issue Information

Dear Colleagues,

Cellular membranes are a highly intricate mixture of proteins and lipids whose role extends far beyond just enclosing the cell contents. The complex nature of its chemical composition contributes to the generation of surprising levels of lateral nanoscale heterogeneity, which seems to be critical to multiple cellular processes. However, the scarcity of tools to access information on the organization of biomembranes at the nanoscale has hindered our understanding of the structure, dynamics, and functions of these heterogeneities. The resolution of standard optical microscopy technologies lies far beyond this scale, so information from this technique is of limited value in this field. However, advanced spectroscopy and microscopy techniques have been able to identify specific interactions between lipid and protein components of the membrane, as well as to detect and characterize nanodomains within both membrane model systems and cellular membranes.
The objective of this Special Issue of Molecules is to highlight original research in the topic of protein–lipid interactions and membrane organization. Review articles on the topic are also welcome for inclusion.

Dr. Fábio Fernandes
Dr. Maria J. Sarmento
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2300 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • protein-lipid interactions
  • membrane organization
  • membrane biophysics
  • nanoscale compartmentalization
  • membrane nanodomains
  • cell membranes
  • membrane models
  • spectroscopy
  • super-resolution microscopy

Published Papers

This special issue is now open for submission.
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