Synthesis and Applications of Organometallic Nucleosides, Nucleotides and Oligonucleotides

Dear Colleagues,

Organometallic oligonucleotides can be defined as relatively short stretches of nucleic acids containing at least one carbon–metal bond. Depending on the metal in question, the synthesis of such oligonucleotides presents unique challenges. On the other hand, covalent metalation also confers oligonucleotides with interesting properties hardly achievable by any other means. Notably, appropriately designed organometallic complexes resist dissociation in dilute metal-deficient aqueous solution, opening up the possibility of various biological applications. The field of organometallic oligonucleotides is diverse but scattered, and the aim of this Special Issue is to bring together research working on the synthesis or the various applications of this emerging class of compounds. Contributions covering all aspects of organometallic or organometalloid (organoboron, -silicon or -germanium) oligonucleotides, both review and primary research articles, are welcome.

Dr. Tuomas Lönnberg
Guest Editor

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• Organometallic
• Oligonucleotide
• Metalation
• Hybridization
• Labeling