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Special Issue "Resveratrol: From the Farm to the Clinic"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 May 2019

Special Issue Editors

Guest Editor
Dr. Thomas Netticadan

Canadian Centre for Agri-Food Research in Health and Medicine, Winnipeg, MB, Canada
Website | E-Mail
Interests: diabetes; hypertension; cardiovascular disease; heart failure; resveratrol; polyphenols; fatty acids
Guest Editor
Dr. Jeffrey Wigle

Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, Canada
Website | E-Mail
Interests: gene expression; molecular biology; cell signaling; endothelial cell biology; resveratrol; cardiovascular system

Special Issue Information

Dear Colleagues,

Resveratrol is a polyphenol found in both edible plant sources such as grapes, peanuts and berries, and in medicinal plants such as polygonum cuspidatum and veratrum album. Resveratrol protects the plant against infections and environmental stresses. Research over the past two decades has also revealed that resveratrol can provide health benefits for animals and humans. In this Special Issue we would like to invite articles in areas such as the application of resveratrol in plant metabolic engineering for the nutritional improvement of food, and as a biopesticide. In addition, articles are invited on new findings on the impact of resveratrol and its analogues in animal and human health, and the underlying mechanisms of action of resveratrol.

Dr. Thomas Netticadan
Dr. Jeffrey Wigle
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Resveratrol
  • Resveratrol analogues
  • Health
  • Disease

Published Papers (1 paper)

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Open AccessArticle
Regulation of Noise-Induced Loss of Serotonin Transporters with Resveratrol in a Rat Model Using 4-[18F]-ADAM/Small-Animal Positron Emission Tomography
Molecules 2019, 24(7), 1344; https://doi.org/10.3390/molecules24071344
Received: 19 February 2019 / Revised: 28 March 2019 / Accepted: 4 April 2019 / Published: 5 April 2019
PDF Full-text (6502 KB) | HTML Full-text | XML Full-text | Supplementary Files
Serotonin (5-HT) plays a crucial role in modulating the afferent fiber discharge rate in the inferior colliculus, auditory cortex, and other nuclei of the ascending auditory system. Resveratrol, a natural polyphenol phytoalexin, can inhibit serotonin transporters (SERT) to increase synaptic 5-HT levels. In [...] Read more.
Serotonin (5-HT) plays a crucial role in modulating the afferent fiber discharge rate in the inferior colliculus, auditory cortex, and other nuclei of the ascending auditory system. Resveratrol, a natural polyphenol phytoalexin, can inhibit serotonin transporters (SERT) to increase synaptic 5-HT levels. In this study, we investigated the effects of resveratrol on noise-induced damage in the serotonergic system. Male Sprague-Dawley rats were anaesthetized and exposed to an 8-kHz tone at 116 dB for 3.5 h. Resveratrol (30 mg/kg, intraperitoneal injection [IP]) and citalopram (20 mg/kg, IP), a specific SERT inhibitor used as a positive control, were administered once a day for four consecutive days, with the first treatment occurring 2 days before noise exposure. Auditory brainstem response testing and positron emission tomography (PET) with N,N-dimethyl-2-(2-amino-4-[18F]fluorophenylthio)benzylamine (4-[18F]-ADAM, a specific radioligand for SERT) were used to evaluate functionality of the auditory system and integrity of the serotonergic system, respectively, before and after noise exposure. Finally, immunohistochemistry was performed 1 day after the last PET scan. Our results indicate that noise-induced serotonergic fiber loss occurred in multiple brain regions including the midbrain, thalamus, hypothalamus, striatum, auditory cortex, and frontal cortex. This noise-induced damage to the serotonergic system was ameliorated in response to treatment with resveratrol and citalopram. However, noise exposure increased the hearing threshold in the rats regardless of drug treatment status. We conclude that resveratrol has protective effects against noise-induced loss of SERT. Full article
(This article belongs to the Special Issue Resveratrol: From the Farm to the Clinic)

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