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Special Issue "Bio-Nanomaterials"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Inorganic Chemistry".

Deadline for manuscript submissions: 31 May 2019

Special Issue Editor

Guest Editor
Prof. Dr. Ick-Soo Kim

Nano Fusion Technology Research Lab., Division of Frontier Fibers, Institute for Fiber Engineering (IFES), Interdisciplinary Cluster for Cutting Edge Research (ICCER), National University Corporation Shinshu University, Matsumoto, Japan
Website | E-Mail
Interests: nano fiber; nano materials; electrospinning; nanocatalysts; nanochemistry; biocompatibility; alloy design

Special Issue Information

Dear Colleagues,

At the interface between nanomaterials and biological systems, an understanding of the interactions between them is of significant interest. Biomolecules, such as DNA, proteins, peptides, virus, enzymes, biopolymers, and others, have unique abilities to form hierarchical and ordered 1D, 2D, and 3D nanostructures and nanomaterials by molecular self-assembly in liquid, solid surface, and air–water interfaces. The resulting bionanomaterials may have potential applications as novel fibers, sensors, adhesives, energy generating and so on, that can be applied in the fields of biomedical engineering, tissue engineering, biosensors, nanotechnology, energy materials, and others. This Special Issue aims to collect and disseminate some of the most significant and recent contributions in the interdisciplinary area of bio-nanomaterials research. Both original research and review papers are welcome.

I am looking forward to your contributions to this Special Issue.

Best regards,

Prof. Dr. Ick-Soo Kim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Self-assembly Nanomaterials
  • Nanotechnology
  • Nanofibers
  • Biopolymers
  • Nanocatalysts
  • Functional tailoring
  • Hybrid materials
  • Tissue engineering
  • Drug delivery
  • Biosensors

Published Papers (1 paper)

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Research

Open AccessArticle
Design of an Amphiphilic Poly(aspartamide)-Mediated Self-Assembled Nanoconstruct for Long-Term Tumor Targeting and Bioimaging
Molecules 2019, 24(5), 885; https://doi.org/10.3390/molecules24050885
Received: 11 February 2019 / Revised: 27 February 2019 / Accepted: 27 February 2019 / Published: 2 March 2019
PDF Full-text (6821 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Biodegradable polymers have been developed for the targeted delivery of therapeutics to tumors. However, tumor targeting and imaging are usually limited by systemic clearance and non-specific adsorption. In this study, we used poly(amino acid) derivatives, such as poly(succinimide), to synthesize a nanomicelle-forming poly(hydroxyethylaspartamide) [...] Read more.
Biodegradable polymers have been developed for the targeted delivery of therapeutics to tumors. However, tumor targeting and imaging are usually limited by systemic clearance and non-specific adsorption. In this study, we used poly(amino acid) derivatives, such as poly(succinimide), to synthesize a nanomicelle-forming poly(hydroxyethylaspartamide) (PHEA, P) modified sequentially with octadecylamine, polyethylene glycol (PEG, P), and glycine (G) to design PHEA-PEG-glycine (PPG) nanoparticles (NPs). These PPG NPs were further tethered to cyclic Arg-Gly-Asp (cRGD) sequences for formulating tumor-targeting PPG-cRGD NPs, and then loaded with IR-780 dye (PPG-cRGD-IR-780) for visualizing tumor homing. cRGD cloaked in PPG NPs could bind specifically to both tumor endothelium and cancer cells overexpressing αvβ3 integrins. PPG-cRGD NPs exhibited enhanced physiological stability, cellular viability, and targeted intracellular uptake in cancer cells. In addition, PPG-cRGD NPs offered enhanced systemic circulation, leading to preferential tumor targeting and prolonged fluorescence tumor imaging for nearly 30 days. Nevertheless, non-targeted formulations demonstrated premature systemic clearance with short-term tumor imaging. Histochemical analysis showed no damage to normal organs, reaffirming the biocompatibility of PHEA polymers. Overall, our results indicated that PPG-cRGD NPs, which were manipulated to obtain optimal particle size and surface charge, and were complemented with tumor targeting, could improve the targeted and theranostic potential of therapeutic delivery. Full article
(This article belongs to the Special Issue Bio-Nanomaterials)
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