Fluorescent Probes for Protein and Nucleic Acid Detection
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (30 September 2019) | Viewed by 2863
Special Issue Editor
Interests: fluorescence imaging; fluorescence; ultrafast dynamics; microscopy; quantitative fluorescence methods; live cell imaging; photophysics; optics
Special Issue Information
Dear Colleagues,
Nucleic acids are essential molecules needed for encoding, transmitting, and expressing genetic information. Numerous key cellular mechanisms rely on their dynamic interaction with proteins, which induce local and transient changes in the DNA secondary and tertiary structure. Although structural methods, such as X-ray diffraction, NMR, or electron microscopy, provide invaluable information on the structure of the protein/nucleic acid complexes, they are less suited for monitoring the dynamic aspects of the interaction and the associated conformational changes, especially in the context of diluted solutions. As a result of their exquisite sensitivity, fluorescence-based techniques are highly potent for exploring the dynamics of molecules in diluted solutions or in cells. The field of fluorescent probes is constantly evolving with the development of innovative tools that can be used in vitro and in cellulo. Therefore, scientists are invited to submit manuscripts illustrating the suitability of newly developed sensors for proteins and nucleic acids detection (in vitro and in cellulo), as well as manuscripts describing novel tools that can be used to assess the dynamics of biomolecular interaction.
Prof. Dr. Pascal Didier
Guest Editor
Manuscript Submission Information
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Keywords
- Fluophores
- Optical probes
- Photophysical sensing
- Binding affinity
- Recognition
- Hybridization
- Fluorescence microscopy
- Single molecule detection
- Fluorescent nucleoside analogues
- FRET measurements
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