Dear Colleagues,

Nucleic acids are essential molecules needed for encoding, transmitting, and expressing genetic information. Numerous key cellular mechanisms rely on their dynamic interaction with proteins, which induce local and transient changes in the DNA secondary and tertiary structure. Although structural methods, such as X-ray diffraction, NMR, or electron microscopy, provide invaluable information on the structure of the protein/nucleic acid complexes, they are less suited for monitoring the dynamic aspects of the interaction and the associated conformational changes, especially in the context of diluted solutions. As a result of their exquisite sensitivity, fluorescence-based techniques are highly potent for exploring the dynamics of molecules in diluted solutions or in cells. The field of fluorescent probes is constantly evolving with the development of innovative tools that can be used in vitro and in cellulo. Therefore, scientists are invited to submit manuscripts illustrating the suitability of newly developed sensors for proteins and nucleic acids detection (in vitro and in cellulo), as well as manuscripts describing novel tools that can be used to assess the dynamics of biomolecular interaction.

Prof. Dr. Pascal Didier
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• Fluophores
• Optical probes
• Photophysical sensing
• Binding affinity
• Recognition
• Hybridization
• Fluorescence microscopy
• Single molecule detection
• Fluorescent nucleoside analogues
• FRET measurements