Electrochemical Biosensors: Design and Applications

Dear colleagues,

Electrochemical biosensors are analytical devices that transduce biochemical events into electrical signals. Their relative robustness, easy miniaturization, excellent detection limits, ability to investigate small-volume samples and turbid biofluids, as well as the relative simplicity of their setup are decisive advantages over other types of biosensors. In the last two decades, the development of viable electrochemical biosensors has attracted ever-increasing attention, generating significant advances in the design of electrodes (often exploiting nanomaterials), as well as in the development of surface modification approaches for the immobilization of bioreceptors. One of the key requirements for innovative biosensors is the ability to monitor analytes using technologies that guarantee both low cost, thus ensuring screening of a large number of samples, and high sensitivity, enabling detection of very small (changes of) levels of target species. This tremendous research effort has led to the introduction of various electrochemistry-driven biosensing methods for the use of simple and miniaturized analytical devices for on-site analysis. The aim of this special issue is to provide an overview of the most recent advances in biosensing with electrochemical devices. We welcome papers describing novel electrochemical platforms (possibly even featuring multiplexing capability) for the detection of biomarkers and metabolites in test solutions and in real biological fluids that could be integrated into portable, wearable biosensors to be operated in the field. The target electrochemical devices are not only amperometric and impedimetric sensors, but might also include innovative architectures, such as organic electrochemical transistors. Examples of devices integrated with microfluidics technologies or fabricated by innovative approaches, such as by additive manufacturing, are most welcome.

Dr. Carlo Augusto Bortolotti
Dr. Gianantonio Battistuzzi
Guest Editors

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