Novel Metal Complexes as Potential Anticancer Agents
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (1 November 2022) | Viewed by 3275
Special Issue Editor
Special Issue Information
Dear Colleagues,
Metal-based anticancer drugs were developed due to their cytotoxic effect and efficacy. Certainly, platinum-based anti-cancer drugs, such as cisplatin, oxaliplatin and carboplatin, represent a mainstay in the treatment of cancer, with indications in the therapy of different types of cancer, such as lung, colorectal and cervical cancer. The possibility to obtain in details structural information about compounds, should allow to develop different metal-based compounds, throughout the substitution and modification of ligands, in order to obtain enhanced cytotoxicity and to reach a specific molecular target. In fact, a new anticancer drug should show many pharmacological characteristics: low toxicity; if possible, a selective target; reliable pharmacokinetic parameters. The design, synthesis and characterization of novel metal complexes could be an opportunity to develop new drugs with potential anticancer activity.
This Special Issue aims to collect papers dealing with novel metal complexes designed, synthesis and characterization to be utilized in cancer treatment.
Dr. Margherita Gallicchio
Guest Editor
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Keywords
- cancer therapy
- anticancer drugs
- metal complexes
- drug discovery and development
- chemical synthesis
- biological activity
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