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Transdermal Therapy using Thermosensitive Poloxamer Hydrogel for Biomedical Application

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (30 November 2019) | Viewed by 9591

Special Issue Editor


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Guest Editor
Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hung Hom, Hong Kong
Interests: healthcare product development; AI; big data; hydrogel applications
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Transdermal therapy using drug-loaded hydrogels can show dual functionality by simultaneously supplying moisture and drugs to the infected sites on the skin, especially for the treatment of atopic dermatitis (AD) or skin eczema. Nevertheless, the drug delivery systems used in transdermal therapy need to overcome the skin barrier’s effect, and target drugs to specific sites on the skin. Various stimuli-responsive hydrogels, especially thermoresponsive hydrogels, are turning out to be effective and affordable skin care treatments for AD. Stimuli-responsive hydrogels formed by various natural and synthetic polymers can show changes in their properties with temperature and pH, and some are capable of showing dual responsiveness. For example, in textile-based transdermal therapy, advanced functionalities can be imparted to the textile materials by integrating stimuli-responsive hydrogels loaded with drugs, which needs to be done prior to coating the fabrics with hydrogel systems for the treatment of AD and other skin diseases. In this aspect, researchers working in the area of drug delivery based on stimuli-responsive hydrogel for textile and other biomedical applications are cordially invited to submit their manuscripts to this Special Issue.

Prof. Dr. Patrick Chi-leung Hui
Guest Editor

Manuscript Submission Information

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Keywords

  • Stimuli-responsive hydrogels
  • Thermoresponsive hydrogels
  • Dual responsive hydrogels (pH/temperature)
  • Drug delivery
  • Transdermal therapy
  • Biomedical Application

Published Papers (1 paper)

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Review

18 pages, 2023 KiB  
Review
Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application
by Sudipta CHATTERJEE and Patrick Chi-leung HUI
Molecules 2019, 24(14), 2547; https://doi.org/10.3390/molecules24142547 - 12 Jul 2019
Cited by 114 | Viewed by 9382
Abstract
This review describes some commercially available stimuli-responsive polymers of natural and synthetic origin, and their applications in drug delivery and textiles. The polymers of natural origin such as chitosan, cellulose, albumin, and gelatin are found to show both thermo-responsive and pH-responsive properties and [...] Read more.
This review describes some commercially available stimuli-responsive polymers of natural and synthetic origin, and their applications in drug delivery and textiles. The polymers of natural origin such as chitosan, cellulose, albumin, and gelatin are found to show both thermo-responsive and pH-responsive properties and these features of the biopolymers impart sensitivity to act differently under different temperatures and pH conditions. The stimuli-responsive characters of these natural polymers have been discussed in the review, and their respective applications in drug delivery and textile especially for textile-based transdermal therapy have been emphasized. Some practically important thermo-responsive polymers such as pluronic F127 (PF127) and poly(N-isopropylacrylamide) (pNIPAAm) of synthetic origin have been discussed in the review and they are of great importance commercially because of their in situ gel formation capacity. Some pH-responsive synthetic polymers have been discussed depending on their surface charge, and their drug delivery and textile applications have been discussed in this review. The selected stimuli-responsive polymers of synthetic origin are commercially available. Above all, the applications of bio-based or synthetic stimuli-responsive polymers in textile-based transdermal therapy are given special regard apart from their general drug delivery applications. A special insight has been given for stimuli-responsive hydrogel drug delivery systems for textile-based transdermal therapy, which is critical for the treatment of skin disease atopic dermatitis. Full article
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