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Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application

Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hung Hom, Hong Kong
Author to whom correspondence should be addressed.
Academic Editors: Jessica Rosenholm and Constantinos Tsitsilianis
Molecules 2019, 24(14), 2547;
Received: 5 June 2019 / Revised: 27 June 2019 / Accepted: 11 July 2019 / Published: 12 July 2019
PDF [2023 KB, uploaded 12 July 2019]


This review describes some commercially available stimuli-responsive polymers of natural and synthetic origin, and their applications in drug delivery and textiles. The polymers of natural origin such as chitosan, cellulose, albumin, and gelatin are found to show both thermo-responsive and pH-responsive properties and these features of the biopolymers impart sensitivity to act differently under different temperatures and pH conditions. The stimuli-responsive characters of these natural polymers have been discussed in the review, and their respective applications in drug delivery and textile especially for textile-based transdermal therapy have been emphasized. Some practically important thermo-responsive polymers such as pluronic F127 (PF127) and poly(N-isopropylacrylamide) (pNIPAAm) of synthetic origin have been discussed in the review and they are of great importance commercially because of their in situ gel formation capacity. Some pH-responsive synthetic polymers have been discussed depending on their surface charge, and their drug delivery and textile applications have been discussed in this review. The selected stimuli-responsive polymers of synthetic origin are commercially available. Above all, the applications of bio-based or synthetic stimuli-responsive polymers in textile-based transdermal therapy are given special regard apart from their general drug delivery applications. A special insight has been given for stimuli-responsive hydrogel drug delivery systems for textile-based transdermal therapy, which is critical for the treatment of skin disease atopic dermatitis. View Full-Text
Keywords: stimuli-responsive polymer; thermo-responsive; pH-responsive; hydrogel; drug delivery; textile stimuli-responsive polymer; thermo-responsive; pH-responsive; hydrogel; drug delivery; textile

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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CHATTERJEE, S.; Chi-leung HUI, P. Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application. Molecules 2019, 24, 2547.

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