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Special Issue "The Versatility of the Curcumin Scaffold for the Design of Bioactive Compounds"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 30 November 2019

Special Issue Editor

Guest Editor
Prof. Dr. Federica Belluti

Department of Pharmacy and Biotechnology, Alma Mater Studiorum—University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
Website | E-Mail
Interests: : naturally inspired compounds; bioactive molecules; curcumin-based analogues; chalcones; coumarins; anti-Alzheimer agents; anti-protozoan compounds; anti-cancer agents

Special Issue Information

Dear Colleagues,

The polyphenol curcumin, found in Curcuma longa L., is one of the most thoroughly investigated natural products, as documented by the impressive number of studies claiming its efficacy for both the prevention and the treatment of a wide number of disorders. This peculiar pleiotropic profile, mainly due to the concomitant modulation of multiple and structurally unrelated targets, could offer promises for addressing complex maladies, such as cancer and Alzheimer’s disease. Curcumin’s α,β-unsaturated carbonyl system, through the modification of the crucial cysteine residues of proteins, is believed to be involved in the bioactivity of this molecule. In this context, this natural compound, regarded as privileged structure, has been largely exploited in medicinal chemistry and new bioactive molecules were discovered, able to either effectively inhibit a single molecular target or innovatively modulate different interconnected pathways.

This Special Issue aims to provide both updates and new perspectives on bioactive curcumin-based analogues. Original articles, short communications, as well as a limited number of reviews of studies on this topic are welcome.

Prof. Dr. Federica Belluti
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Alzheimer’s disease
  • Bioactive compounds
  • Cancer
  • Curcumin
  • Drug design
  • Drug synthesis
  • Medicinal chemistry
  • Naturally inspired molecules
  • Structure–activity relationship (SAR) study

Published Papers

This special issue is now open for submission.
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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