Special Issue "The Versatility of the Curcumin Scaffold for the Design of Bioactive Compounds"
Deadline for manuscript submissions: 30 November 2019
Prof. Dr. Federica Belluti
Department of Pharmacy and Biotechnology, Alma Mater Studiorum—University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
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Interests: : naturally inspired compounds; bioactive molecules; curcumin-based analogues; chalcones; coumarins; anti-Alzheimer agents; anti-protozoan compounds; anti-cancer agents
The polyphenol curcumin, found in Curcuma longa L., is one of the most thoroughly investigated natural products, as documented by the impressive number of studies claiming its efficacy for both the prevention and the treatment of a wide number of disorders. This peculiar pleiotropic profile, mainly due to the concomitant modulation of multiple and structurally unrelated targets, could offer promises for addressing complex maladies, such as cancer and Alzheimer’s disease. Curcumin’s α,β-unsaturated carbonyl system, through the modification of the crucial cysteine residues of proteins, is believed to be involved in the bioactivity of this molecule. In this context, this natural compound, regarded as privileged structure, has been largely exploited in medicinal chemistry and new bioactive molecules were discovered, able to either effectively inhibit a single molecular target or innovatively modulate different interconnected pathways.
This Special Issue aims to provide both updates and new perspectives on bioactive curcumin-based analogues. Original articles, short communications, as well as a limited number of reviews of studies on this topic are welcome.
Prof. Dr. Federica Belluti
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- Alzheimer’s disease
- Bioactive compounds
- Drug design
- Drug synthesis
- Medicinal chemistry
- Naturally inspired molecules
- Structure–activity relationship (SAR) study