E-Mail Alert

Add your e-mail address to receive forthcoming issues of this journal:

Journal Browser

Journal Browser

Special Issue "Advanced Self-Assembled Nanostructures"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Nanochemistry".

Deadline for manuscript submissions: 30 April 2019

Special Issue Editor

Guest Editor
Dr. Angelina Angelova

CNRS UMR 8612 "Institut Galien Paris-Sud", Paris-Sud 11 University, Paris-Saclay University, F-92296 Châtenay Malabry, France
Website | E-Mail
Interests: lipid/protein self-assembly; self-assembled nanostructures and nanoparticles with neuroprotective properties; liquid crystalline phases; cubosomes; protein and peptide-based nanomedicines; nanocarriers for macromolecular drug delivery; membrane receptor nanoscale organization; lipid; peptide; BDNF; cyclodextrin; soft nanomaterials

Special Issue Information

Dear Colleagues,

This Special Issue focuses on advanced self-assembled nanostructures inspired by the supramolecular organizations of biomolecules in living systems and by the formation of protein macromolecular complexes in cellular membranes and subcellular compartments. All kinds of functional self-assembled nanostructures will be considered including organized protein assemblies, lipid/protein supramolecular nanoarchitectures, dynamic nanostructures formed by cell penetrating peptides and other biomolecules, self-assembled nanostructures for nanomedicine applications, biomimetic nanostructures, and synthetic assemblies for multimodal theranostic imaging, etc. Reports involving characterization techniques at the nanoscale, such as cryo-transmission electron microscopy (cryoTEM) and super-resolution fluorescence microscopy imaging, will be of particular interest.

Dr. Angelina Angelova
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access bimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Peptide self-assembled nanostructures
  • Protein macromolecular complexes
  • Biomolecular machines
  • Lipid/polymer hybrid assemblies
  • Liquid crystalline self-assembled nanostructures
  • Drug delivery nanostructures (protein, peptide, siRNA, CRISPR/Cas9)
  • Soft nanostructured materials
  • Soft nanostructure characterization techniques
  • Multimodal theranostic assemblies

Published Papers (1 paper)

View options order results:
result details:
Displaying articles 1-1
Export citation of selected articles as:

Research

Open AccessArticle An Intelligent Nanoscale Insulin Delivery System
Molecules 2018, 23(11), 2945; https://doi.org/10.3390/molecules23112945
Received: 15 October 2018 / Revised: 2 November 2018 / Accepted: 9 November 2018 / Published: 11 November 2018
PDF Full-text (3435 KB) | HTML Full-text | XML Full-text
Abstract
Insulin injection relies on strict blood glucose monitoring. However, existing techniques and algorithms for blood glucose monitoring cannot be completed in a timely way. In this study, we have developed a new intelligent glucose-sensitive insulin delivery system to stabilize blood glucose levels in
[...] Read more.
Insulin injection relies on strict blood glucose monitoring. However, existing techniques and algorithms for blood glucose monitoring cannot be completed in a timely way. In this study, we have developed a new intelligent glucose-sensitive insulin delivery system to stabilize blood glucose levels in the body. This system does not require real-time detection of blood glucose. First, we successfully synthesized a nanoscale material called PAM-PAspPBA-b-PEG by using chemical methods. We then conducted TEM, DLS, and 1H-NMR analyses to characterize the physicochemical properties, such as size, molecular composition, and configuration of the nanomaterial. We verified the glucose responsibility of the insulin loading nanoscale material in vitro and evaluated its safety and effect on mice in vivo. Results showed that insulin-loaded PAM-PAspPBA-b-PEG is glucose-sensitive, safer and more effective than regular insulin injection. This study provides a basis for future development of smart insulin delivery systems. Full article
(This article belongs to the Special Issue Advanced Self-Assembled Nanostructures)
Figures

Figure 1

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top