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Advances in Phenolic Based Complexes

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organometallic Chemistry".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 1578

Special Issue Editor


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Guest Editor
Department of Chemical Sciences, Medical University of Plovdiv, 4004 Plovdiv, Bulgaria
Interests: coordination compounds; ion-association; solvent extraction; cloud point extraction; spectrophotometry; azo dyes; tetrazolium salts; vanadium; transition metals
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Special Issue Information

Dear Colleagues,

The significance of phenolic compounds as ligands is derived from their capacity to donate electrons through the hydroxyl group, form chelate complexes, stabilize disparate metal oxidation states, and participate in biological and catalytic processes. Their adaptable binding modes and chemical reactivity render them highly valuable in inorganic, bioinorganic, and analytical chemistry. Phenolic-based complexes are of significance in a variety of fields, including medicine, the food industry, catalysis, green chemistry, water treatment, soil remediation, environmental analysis, material science, drug delivery, nanomaterials, energy storage, and more.

The objective of this Special Issue is to provide a forum for the dissemination of research findings pertaining to complexes based on phenolic compounds. We invite interested parties to submit manuscripts for consideration. Contributions may take the form of full papers, briefs, or reviews.

Dr. Kiril B. Gavazov
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • phenolic compounds
  • complexes
  • structure
  • properties
  • applications
  • analysis

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Published Papers (2 papers)

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Research

16 pages, 3538 KiB  
Article
A Semi-Micro Extraction Spectrophotometric Determination of Iron Using 4-Nitrocatechol and Xylometazoline Hydrochloride
by Petya V. Racheva, Antoaneta D. Saravanska, Galya K. Toncheva, Denitsa D. Kiradzhiyska, Nikolina P. Milcheva, Vidka V. Divarova, Ina P. Pencheva, Kirila T. Stojnova, Vassil B. Delchev and Kiril B. Gavazov
Molecules 2025, 30(4), 899; https://doi.org/10.3390/molecules30040899 - 15 Feb 2025
Viewed by 467
Abstract
A chromogenic solvent extraction system for Fe(III) based on 4-nitrocatechol (4NC) and xylometazoline hydrochloride (XMH) was investigated. The optimum conditions for extraction spectrophotometric determination of iron were found. Under these conditions, the formula of the extracted complex was (XMH+)3[Fe(4NC) [...] Read more.
A chromogenic solvent extraction system for Fe(III) based on 4-nitrocatechol (4NC) and xylometazoline hydrochloride (XMH) was investigated. The optimum conditions for extraction spectrophotometric determination of iron were found. Under these conditions, the formula of the extracted complex was (XMH+)3[Fe(4NC)3] and the apparent molar absorption coefficient at λmax = 464 nm was 1.9 × 105 dm3 mol−1 cm−1 (4-fold enrichment). To validate the aforementioned formula and gather information about the spin state of the central Fe(III) ion, a combined experimental-theoretical approach was employed. This approach entailed the experimental determination of the 4NC:Fe and XMH:Fe molar ratios and the optimization of potential color-bearing structures utilizing the B3LYP/6-311G computational chemistry method. The effect of foreign ions was thoroughly examined, and a sensitive, simple, and inexpensive analytical procedure was proposed, which was successfully applied for determining iron in pharmaceutical and industrial samples. Full article
(This article belongs to the Special Issue Advances in Phenolic Based Complexes)
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19 pages, 4662 KiB  
Article
Preparation and Properties of Chitosan Complexes Consisting of Artemisia argyi Volatile Oil Nanoemulsion
by Shun Zhang, Kewei Zuo, Lijun Zhang, Chenlu Zhang and Juan Shi
Molecules 2025, 30(3), 585; https://doi.org/10.3390/molecules30030585 - 27 Jan 2025
Viewed by 745
Abstract
Artemisia argyi volatile oil (AAVO) is a kind of natural oil with abundant active components and remarkable medicinal and healthcare value. However, AAVO has low solubility, stability, and bioavailability. Here, to address these issues, a nanoemulsion system of Artemisia argyi volatile oil (AAVO-Ne) [...] Read more.
Artemisia argyi volatile oil (AAVO) is a kind of natural oil with abundant active components and remarkable medicinal and healthcare value. However, AAVO has low solubility, stability, and bioavailability. Here, to address these issues, a nanoemulsion system of Artemisia argyi volatile oil (AAVO-Ne) is constructed using phase transition titration, and the conditions are continuously optimized to combine it with chitosan, forming a chitosan composite of the volatile oil nanoemulsion (AAVO-NeCs). The structure was analyzed using Fourier transform infrared (FT-IR) spectroscopy, and the performance was evaluated through in vitro antibacterial tests, in vitro release experiments, and antioxidant assays. The results indicated that the typical characteristic absorption peaks of AAVO shifted in the AAVO-Ne spectrum and new absorption peaks appeared in the AAVO-NeCs, which implied that the formation of AAVO-NeCs involved not only a physical encapsulation process but also certain chemical interactions, thus enhancing the stability and bioactivity of the composites. Compared to AAVO, AAVO-NeCs exhibited a 1.87-fold increase in antibacterial activity against antibiotic-resistant bacteria. Meanwhile, the in vitro release study demonstrated that AAVO-NeCs exhibited a biphasic release pattern. Compared to AAVO-Ne and AAVO, AAVO-NeCs also showed a significant enhancement in antioxidant activity. Overall, AAVO-NeCs demonstrate improved solubility and efficacy of AAVO, as well as high-efficiency delivery, antibacterial, sustained-release, and antioxidant properties. These attributes position AAVO-NeCs as a promising candidate for applications in drug delivery, food preservation, and other fields, offering innovative solutions and contributing to the sustainable development of related industries. Full article
(This article belongs to the Special Issue Advances in Phenolic Based Complexes)
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