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Special Issue "Chemistry of Peroxides"

A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: closed (30 April 2020).

Special Issue Editor

Prof. Alexander O. Terent'ev
Website
Guest Editor
Chief of Laboratory in the N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Faculty of Chemical and Pharmaceutical Technology and Biomedical Products, D.I. Mendeleev University of Chemical Technology of Russia, Moscow 125047, Russia
Interests: chemistry of peroxides; oxidative coupling reactions; reactions with C-, O-, and S-centered radicals; direct and indirect electroorganic synthesis; homogeneous and heterogeneous catalysis in oxidation reactions; compounds with antiparasitic, cytotoxic and antimicrobial activity, agrochemistry; chemistry of aliphatic and alicyclic functionalized compounds

Special Issue Information

Dear Colleagues,

We are very pleased to invite you to submit articles to a high-profile Special Issue on the “Chemistry of peroxides” to be published in Molecules.

This Special Issue aims to highlight various studies in the field of the chemistry of organic peroxides.

The chemistry of organic peroxides attracts considerable attention from chemists, biochemists, physicians and pharmacologists, since it has been found that organic peroxides possess a broad spectrum of biological activity: antimalarial, anthelmintic, anticancer, growth regulating, and antiviral. The importance of these studies is illustrated by the 2015 Nobel Prize in Medicine awarded to Youyou Tu for the discovery and development of Artemisinin, a natural peroxide antimalarial drug. Recently, the first commercial antimalarial agent was developed by combining synthetic ozonide Arterolane with Piperaquine. Organic peroxides derived from ketones are produced in the multi-ton amounts and are broadly used as radical initiators for the preparation of polymers.

Over the past decade, a great deal of attention has been paid to the development of methods for the synthesis of peroxides and their reactions, to the synthesis of peroxides with valuable applied properties, and the study of their stability, and chemical and physical properties.

This Special Issue will include reviews, articles and communications on the synthesis, reactions, transformations and properties of organic peroxides.

In the case of a review article an additional brief (1–2 page) description of the topic including a draft index is required. This preliminary step is essential to avoid the overlapping of topics.

Prof. Dr. Alexander O. Terent'ev
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • organic peroxides
  • cyclic peroxides
  • hydrogen peroxide
  • ozone
  • oxygen
  • singlet oxygen
  • peroxidation
  • oxidation
  • free radicals
  • synthesis
  • catalysis
  • rearrangements
  • bioactive peroxides
  • initiators

Published Papers (3 papers)

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Research

Open AccessArticle
Cyclic Synthetic Peroxides Inhibit Growth of Entomopathogenic Fungus Ascosphaera apis without Toxic Effect on Bumblebees
Molecules 2020, 25(8), 1954; https://doi.org/10.3390/molecules25081954 - 22 Apr 2020
Abstract
In recent years, the number of pollinators in the world has significantly decreased. A possible reason for this is the toxic effects of agrochemicals reducing the immunity of insects that leads to their increased susceptibility to pathogens. Ascosphaera apis is a dangerous entomopathogenic [...] Read more.
In recent years, the number of pollinators in the world has significantly decreased. A possible reason for this is the toxic effects of agrochemicals reducing the immunity of insects that leads to their increased susceptibility to pathogens. Ascosphaera apis is a dangerous entomopathogenic fungus, afflicting both honeybees and bumblebees. We investigated fungicide activity of cyclic synthetic peroxides against A. apis isolated from Bombus terrestris L. The peroxides exhibited high mycelium growth inhibition of A. apis up to 94–100% at concentration 30 mg/L. EC50 values were determined for the most active peroxides. Two peroxides showed higher antifungal activity against A. apis than the commercial fungicide Triadimefon. The studied peroxides did not reduce the ability of bumblebees to fly and did not lead to the death of bumblebees. A new field of application for peroxides was disclosed. Full article
(This article belongs to the Special Issue Chemistry of Peroxides)
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Open AccessArticle
First Example of Catalytic Synthesis of Cyclic S-Containing Di- and Triperoxides
Molecules 2020, 25(8), 1874; https://doi.org/10.3390/molecules25081874 - 18 Apr 2020
Abstract
An efficient method for the synthesis of tetraoxathiaspiroalkanes, tetraoxathiocanes, and hexaoxathiadispiroalkanes was developed by reactions of pentaoxacanes, pentaoxaspiroalkanes, and heptaoxadispiroalkanes with hydrogen sulfide in the presence of a catalyst, Sm(NO3)3·6H2O. We found that the synthesized S-containing di- [...] Read more.
An efficient method for the synthesis of tetraoxathiaspiroalkanes, tetraoxathiocanes, and hexaoxathiadispiroalkanes was developed by reactions of pentaoxacanes, pentaoxaspiroalkanes, and heptaoxadispiroalkanes with hydrogen sulfide in the presence of a catalyst, Sm(NO3)3·6H2O. We found that the synthesized S-containing di- and triperoxides exhibit high cytotoxic activity against Jurkat, K562, U937, and HL60 tumor cultures, and fibroblasts. Full article
(This article belongs to the Special Issue Chemistry of Peroxides)
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Open AccessArticle
Eggplant Germination is Promoted by Hydrogen Peroxide and Temperature in an Independent but Overlapping Manner
Molecules 2019, 24(23), 4270; https://doi.org/10.3390/molecules24234270 - 23 Nov 2019
Cited by 1
Abstract
Hydrogen peroxide promotes seed germination, but the molecular mechanisms underlying this process are unclear. This study presents the results of eggplant (Solanum melongena) germination analyses conducted at two different temperatures and follows the effect of hydrogen peroxide treatment on seed germination [...] Read more.
Hydrogen peroxide promotes seed germination, but the molecular mechanisms underlying this process are unclear. This study presents the results of eggplant (Solanum melongena) germination analyses conducted at two different temperatures and follows the effect of hydrogen peroxide treatment on seed germination and the seed proteome. Hydrogen peroxide was found to promote eggplant germination in a way not dissimilar to that of increased temperature stimuli. LC–MS profiling detected 729 protein families, 77 of which responded to a temperature increase or hydrogen peroxide treatment. These differentially abundant proteins were found to be involved in a number of processes, including protein and amino acid metabolism, carbohydrate metabolism, and the glyoxylate cycle. There was a very low overlap between hydrogen peroxide and temperature-responsive proteins, highlighting the differences behind the seemingly similar outcomes. Furthermore, the observed changes from the seed proteome indicate that hydrogen peroxide treatment diminished the seed endogenous hydrogen peroxide pool and that a part of manifested positive hydrogen peroxide effect might be related to altered sensitivity to abscisic acid. Full article
(This article belongs to the Special Issue Chemistry of Peroxides)
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