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Peptide Aggregates as Up-and-Coming Multivalent Biotechonogical Tools

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Applied Chemistry".

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 16469

Special Issue Editors


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Guest Editor
1. Department of Pharmacy, Via Domenico Montesano 49, 80131 Naples, Italy
2. Research Centre on Bioactive Peptides (CIRPeB), University of Naples “Federico II”, 80134 Naples, Italy
Interests: peptide self-assembling; peptide-based materials; amyloid materials; hydrogels; fibers; material characterization; co-assembly
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Guest Editor
Departiment of Pharmacy, University of Naples "Federico II", Italian Peptide Society (ItPS), Naples, Italy
Interests: peptide-based materials; supramolecular chemistry; peptide self-assembly; peptide chemistry; metal complexes; diagnostic tools; hydrogels; bioactive peptides; supramolecular drug delivery systems; liposomes; active targeting

Special Issue Information

Dear Colleagues,

In collaboration with Prof. Antonella Accardo, I am glad and honored to announce as Guest Editor a Special Issue of Molecules on “Peptide Aggregates as Multivalent Biotechonogical Tools”.

Peptide chemistry and development is a rapidly growing field and the area of bioinspired and biomimetic materials for biotechnological applications is particularly fascinating. Nanofibers, hydrogels, nanovescicles, and nanowires are just a few examples of the peptide-based aggregates recently generated by “bottom-up” and “top-down” approaches. Thanks to the multivalent features of the final aggregate, the introduction of several nanomaterials represents a radical milestone in the progress of several research areas.

Stimulating a multidisciplinary approach, peptide aggregates exhibit astonishing self-aggregation capabilities with tuneable features, allowing for the generation of structural or functional tools in nanomedicine. The interest in these peptide-based aggregates is enhanced by their capability to fuse unexpected functional properties (including electrical, optoelectronic, piezoelectric, and mechanical ones) with a noteworthy in vitro and in vivo biocompatibility.

This Special Issue deals with aspects of peptide aggregates’ hierarchical organization, supramolecular structuration, and potential biomedical applications relevant to drug delivery, tissue engineering, active pharmaceutical ingredient encapsulation (e.g., therapeutic and/or diagnostic agents), innovative treatments, investigation of self-assembling phenomena, optimization of material properties, and structural and functional analysis.

Full research articles and reviews covering these topics or similar ones are welcome.

Dr. Carlo Diaferia
Prof. Dr. Antonella Accardo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • peptide aggregates
  • self-assembling peptides
  • peptide-based materials
  • peptide–polymer conjugates
  • structural characterization
  • bioinspired materials
  • biomolecular vehicles for drug delivery
  • functional peptides
  • nanomedicine
  • stimuli-responsive aggregates
  • hydrogels
  • nanofibers
  • nanotubes
  • hybrid materials
  • biotechnological applications

Published Papers (3 papers)

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Review

15 pages, 3331 KiB  
Review
Optical Polarization-Based Measurement Methods for Characterization of Self-Assembled Peptides’ and Amino Acids’ Micro- and Nanostructures
by Amir Handelman
Molecules 2022, 27(6), 1802; https://doi.org/10.3390/molecules27061802 - 10 Mar 2022
Cited by 2 | Viewed by 2658
Abstract
In recent years, self-assembled peptides’ and amino acids’ (SAPA) micro- and nanostructures have gained much research interest. Here, description of how SAPA architectures can be characterized using polarization-based optical measurement methods is provided. The measurement methods discussed include: polarized Raman spectroscopy, polarized imaging [...] Read more.
In recent years, self-assembled peptides’ and amino acids’ (SAPA) micro- and nanostructures have gained much research interest. Here, description of how SAPA architectures can be characterized using polarization-based optical measurement methods is provided. The measurement methods discussed include: polarized Raman spectroscopy, polarized imaging microscopy, birefringence imaging, and fluorescence polarization. An example of linear polarized waveguiding in an amino acid Histidine microstructure is discussed. The implementation of a polarization-based measurement method for monitoring peptide self-assembly processes and for deriving molecular orientation of peptides is also described. Full article
(This article belongs to the Special Issue Peptide Aggregates as Up-and-Coming Multivalent Biotechonogical Tools)
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21 pages, 5099 KiB  
Review
Self-Assembling Peptides and Carbon Nanomaterials Join Forces for Innovative Biomedical Applications
by Petr Rozhin, Costas Charitidis and Silvia Marchesan
Molecules 2021, 26(13), 4084; https://doi.org/10.3390/molecules26134084 - 4 Jul 2021
Cited by 17 | Viewed by 6695
Abstract
Self-assembling peptides and carbon nanomaterials have attracted great interest for their respective potential to bring innovation in the biomedical field. Combination of these two types of building blocks is not trivial in light of their very different physico-chemical properties, yet great progress has [...] Read more.
Self-assembling peptides and carbon nanomaterials have attracted great interest for their respective potential to bring innovation in the biomedical field. Combination of these two types of building blocks is not trivial in light of their very different physico-chemical properties, yet great progress has been made over the years at the interface between these two research areas. This concise review will analyze the latest developments at the forefront of research that combines self-assembling peptides with carbon nanostructures for biological use. Applications span from tissue regeneration, to biosensing and imaging, and bioelectronics. Full article
(This article belongs to the Special Issue Peptide Aggregates as Up-and-Coming Multivalent Biotechonogical Tools)
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34 pages, 3530 KiB  
Review
Forward Precision Medicine: Micelles for Active Targeting Driven by Peptides
by Filippo Prencipe, Carlo Diaferia, Filomena Rossi, Luisa Ronga and Diego Tesauro
Molecules 2021, 26(13), 4049; https://doi.org/10.3390/molecules26134049 - 2 Jul 2021
Cited by 15 | Viewed by 6081
Abstract
Precision medicine is based on innovative administration methods of active principles. Drug delivery on tissue of interest allows improving the therapeutic index and reducing the side effects. Active targeting by means of drug-encapsulated micelles decorated with targeting bioactive moieties represents a new frontier. [...] Read more.
Precision medicine is based on innovative administration methods of active principles. Drug delivery on tissue of interest allows improving the therapeutic index and reducing the side effects. Active targeting by means of drug-encapsulated micelles decorated with targeting bioactive moieties represents a new frontier. Between the bioactive moieties, peptides, for their versatility, easy synthesis and immunogenicity, can be selected to direct a drug toward a considerable number of molecular targets overexpressed on both cancer vasculature and cancer cells. Moreover, short peptide sequences can facilitate cellular intake. This review focuses on micelles achieved by self-assembling or mixing peptide-grafted surfactants or peptide-decorated amphiphilic copolymers. Nanovectors loaded with hydrophobic or hydrophilic cytotoxic drugs or with gene silence sequences and externally functionalized with natural or synthetic peptides are described based on their formulation and in vitro and in vivo behaviors. Full article
(This article belongs to the Special Issue Peptide Aggregates as Up-and-Coming Multivalent Biotechonogical Tools)
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