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Gels
Special Issues
Innovative Applications of Gelated Matrices in Biomedical and Environmental Engineering
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Innovative Applications of Gelated Matrices in Biomedical and Environmental Engineering

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: 15 June 2025 | Viewed by 1778

Special Issue Editors

Dr. Célio Fernandes

E-Mail Website
Guest Editor
Center for Studies of Transport Phenomena (CEFT), Department of Mechanical Engineering, Faculty of Engineering, University of Porto, 4200-465 Porto, Portugal
Interests: polymer processing; viscoelasticity; particle-laden flows; thermo-fluids; computational rheology
Special Issues, Collections and Topics in MDPI journals
Dr. Sérgio Veloso

E-Mail Website
Guest Editor
1. Centre of Physics, Universities of Minho and Porto, 4710-057 Braga, Portugal
2. Centro De Investigaciones Biomédicas (CINBIO), Universidade de Vigo, 36310 Vigo, Spain
Interests: self-assembly; hydrogels; nanogels; liposomes; magnetic nanoparticles; plasmonic nanoparticles; drug delivery
Special Issues, Collections and Topics in MDPI journals
Dr. Enrico Gallo

E-Mail Website1 Website2
Guest Editor
IRCCS Synlab SDN, Via G. Ferraris 144, 80146 Naples, Italy
Interests: hydrogels; nanogels; bioactive peptides; peptides as diagnostic and therapeutics; supramolecular chemistry; diagnostic and drug delivery technologies; material characterization; nanomedicine
Special Issues, Collections and Topics in MDPI journals
Dr. Carlo Diaferia

E-Mail Website
Guest Editor
1. Department of Pharmacy, Via Domenico Montesano 49, 80131 Naples, Italy
2. Research Centre on Bioactive Peptides (CIRPeB), University of Naples “Federico II”, 80134 Naples, Italy
Interests: peptide self-assembling; peptide-based materials; amyloid materials; hydrogels; fibers; material characterization; co-assembly
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The field of gel science and technology is witnessing rapid advancements, starting a new era where gelated matrices emerge as pivotal tools across a spectrum of applications. This Special Issue of Gels, titled "Innovative Applications of Gelated Matrices in Biomedical and Environmental Engineering", aims to collect cutting-edge research and innovative developments that highlight the versatility and potential of gel-based systems.

Gelated matrices, characterized by their unique viscoelastic properties and tunable physical characteristics, are increasingly being explored for their applications in diverse areas including biomedicine, materials science, environmental engineering, and beyond. This Special Issue invites contributions that explore the synthesis, characterization, and application of these novel gel systems.

We encourage the submission of original research articles, comprehensive reviews, and insightful perspectives that offer new insights into the field of gelated matrices. By bringing together a diverse collection of studies, this Special Issue aims to underscore the transformative impact of gel-based technologies and inspire future innovations.

Dr. Célio Fernandes
Dr. Sérgio Veloso
Dr. Enrico Gallo
Dr. Carlo Diaferia
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gelated matrices
  • hydrogels
  • gelation mechanisms
  • biocompatible gels
  • drug delivery systems
  • tissue engineering
  • wound healing
  • biosensing
  • stimuli-responsive gels
  • multifunctional gels
  • organogels
  • gel nanoparticles
  • gel formulation
  • nanogels
  • gel rheology

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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18 pages, 4909 KiB  
Article
Thermally Solvent-Free Cross-Linked pH/Thermosensitive Hydrogels as Smart Drug Delivery Systems
by Sanda Bucatariu, Bogdan Cosman, Marieta Constantin, Gabriela Liliana Ailiesei, Daniela Rusu and Gheorghe Fundueanu
Gels 2024, 10(12), 834; https://doi.org/10.3390/gels10120834 - 18 Dec 2024
Cited by 1 | Viewed by 1052
Abstract
An imbalance in the body’s pH or temperature may modify the immune response and result in ailments such as autoimmune disorders, infectious diseases, cancer, or diabetes. Dual pH- and thermo-responsive carriers are being evaluated as advanced drug delivery microdevices designed to release pharmaceuticals [...] Read more.
An imbalance in the body’s pH or temperature may modify the immune response and result in ailments such as autoimmune disorders, infectious diseases, cancer, or diabetes. Dual pH- and thermo-responsive carriers are being evaluated as advanced drug delivery microdevices designed to release pharmaceuticals in response to external or internal stimuli. A novel drug delivery system formulated as hydrogel was developed by combining a pH-sensitive polymer (the “biosensor”) with a thermosensitive polymer (the delivery component). Thus, the hydrogel was created by cross-linking, using a solvent-free thermal approach, of poly(N-isopropylacrylamide-co-N-hydroyethyl acrylamide), P(NIPAAm-co-HEAAm), and poly(methylvinylether-alt-maleic acid), P(MVE/MA). The chemical structure of the polymers and hydrogels was analyzed using Fourier-transform infrared (FTIR) and proton nuclear magnetic resonance (1H NMR) spectroscopies. The pH/thermosensitive hydrogel loses its thermosensitivity under physiological conditions but, remarkably, can recover the thermosensitive capabilities when certain physiologically active biomolecules, acting as triggering agents, electrostatically interact with pH-sensitive units. Our research aimed to develop a drug delivery system that could identify the disturbance of normal physiological parameters and instantaneously send a signal to thermosensitive units, which would collapse and modulate the release profiles of the drug. Full article
(This article belongs to the Special Issue Innovative Applications of Gelated Matrices in Biomedical and Environmental Engineering)
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Review

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27 pages, 6626 KiB  
Review
Multifunctional Janus Hydrogels: Surface Design Strategies for Next-Generation Clinical Solutions
by Taoxu Yan, Junyao Cheng, Haoming Liu, Yifan Wang, Chuyue Zhang, Da Huang, Jianheng Liu and Zheng Wang
Gels 2025, 11(5), 343; https://doi.org/10.3390/gels11050343 - 6 May 2025
Viewed by 304
Abstract
Janus hydrogels, distinguished by their dual-sided structure with distinct physical and chemical properties, have garnered significant attention in the medical field, particularly for applications in drug delivery, tissue engineering, and wound healing. Their ability to simultaneously perform multiple functions, such as targeted drug [...] Read more.
Janus hydrogels, distinguished by their dual-sided structure with distinct physical and chemical properties, have garnered significant attention in the medical field, particularly for applications in drug delivery, tissue engineering, and wound healing. Their ability to simultaneously perform multiple functions, such as targeted drug release and biomimetic tissue interaction, positions them as a promising platform for advanced therapeutic strategies. The growing interest in these hydrogels is primarily driven by their multifunctionality and capacity to address complex biological needs. This review delves into the design, fabrication methods, and applications of Janus hydrogels in medicine, focusing on their potential to overcome the limitations of conventional therapies and providing a comprehensive overview of their role in contemporary biomedical applications. Full article
(This article belongs to the Special Issue Innovative Applications of Gelated Matrices in Biomedical and Environmental Engineering)
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