molecules-logo

Journal Browser

Journal Browser

New Synthetic Methods towards Biologically Relevant Compounds

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 3299

Special Issue Editor

School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China
Interests: asymmetric catalysis; transition metal catalysis; atom economy; diversity-oriented synthesis

Special Issue Information

Dear Colleagues,

The synthesis of biologically relevant organic compounds is of fundamental importance in medicinal chemistry and drug development. As a result, great efforts have been continuously made on the development of new synthetic methodologies from the synthetic community. The past decade has witnessed the booming progress on a large number of novel organic transformations, to name several of them, for example, photocatalytic reaction, electrochemical reaction, flow chemistry, etc. New synthetic method development relies greatly on the utilization of new types of catalysts, reagents or technologies, and has greatly enriched the arsenal towards the synthesis of biologically relevant organic compounds. Among them, the rapid construction of new molecule entities (NME) for biological evaluations, step- and atom-economic methods toward biologically active molecules, and late-stage functionalization of pharmaceuticals and drugs are of particular importance. This Special Issue aims to provide a broad overview of the latest development on the development of new synthetic methods toward biologically relevant organic compounds.

Dr. Dong Xing
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • synthetic methods
  • organic synthesis
  • biologically relevant compounds
  • pharmaceuticals
  • drugs
  • biologically active molecules

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

15 pages, 1306 KiB  
Article
Boron Trifluoride Etherate Promoted Regioselective 3-Acylation of Indoles with Anhydrides
by Yunyun Zheng, Jiuling Li and Kai Wei
Molecules 2022, 27(23), 8281; https://doi.org/10.3390/molecules27238281 - 28 Nov 2022
Viewed by 1568
Abstract
An efficient, high-yielding and scalable procedure for the regioselective 3-acylation of indoles with anhydrides promoted by boron trifluoride etherate under mild conditions was reported. This novel protocol provided a simple way to prepare 3-(benzofuran-2-yl) indole in three steps. Full article
(This article belongs to the Special Issue New Synthetic Methods towards Biologically Relevant Compounds)
Show Figures

Graphical abstract

11 pages, 3075 KiB  
Article
Synthetic Optimizations for Gram-Scale Preparation of 1-O-Methyl d-Glycero-α-d-gluco-heptoside 7-Phosphate from d-Glucose
by Konstantin V. Potapov, Roman A. Novikov, Pavel N. Solyev, Sergey N. Kochetkov, Alexander A. Makarov and Vladimir A. Mitkevich
Molecules 2022, 27(21), 7534; https://doi.org/10.3390/molecules27217534 - 03 Nov 2022
Cited by 1 | Viewed by 1409
Abstract
Heptose phosphates—unique linkers between endotoxic lipid A and O-antigen in the bacterial membrane—are pathogen-associated molecular patterns recognized by the receptors of the innate immune system. Understanding the mechanisms of immune system activation is important for the development of therapeutic agents to combat [...] Read more.
Heptose phosphates—unique linkers between endotoxic lipid A and O-antigen in the bacterial membrane—are pathogen-associated molecular patterns recognized by the receptors of the innate immune system. Understanding the mechanisms of immune system activation is important for the development of therapeutic agents to combat infectious diseases and overcome antibiotic resistance. However, in practice, it is difficult to obtain a substantial amount of heptose phosphates for biological studies due to the narrow scope of the reported synthetic procedures. We have optimized and developed an inexpensive and convenient synthesis for the first performed gram-scale production of 1-O-methyl d-glycero-α-d-gluco-heptoside 7-phosphate from readily available d-glucose. Scaling up to such amounts of the product, we have increased the efficiency of the synthesis and reduced the number of steps of the classical route through the direct phosphorylation of the O6,O7-unprotected heptose. The refined method could be of practical value for further biological screening of heptose phosphate derivatives. Full article
(This article belongs to the Special Issue New Synthetic Methods towards Biologically Relevant Compounds)
Show Figures

Figure 1

Back to TopTop